Specifications
- Pk:50 µG
- Protein/peptide type:Recombinant
- Source:Cells
- Species:Human
- Environmentally Preferable:
- Tag sequence:C-6 His tag
- Storage conditions:Lyophilized protein should be stored at −20 °C, though stable at room temperature for 3 weeks. Reconstituted protein solution can be stored at 4-7 °C for 2-7 days. Aliquots of reconstituted samples are stable at −20 °C for 3 months.
- Protein synonyms:Sphingolipid activator protein 3|Ganglioside GM2 activator|GM2A|Cerebroside sulfate activator protein|SAP-3|GM2-AP
- Protein/peptide name:Ganglioside GM2 activator
- Purity:> 95% as determined by reducing SDS-PAGE
- Molecular weight:18.6 kD
- Sequence:Ser32-Ile193
- Formulation:Lyophilized from a 0.2 um filtered solution of 20mM TrisHCl,150mM NaCl,pH7.5. Always centrifuge tubes before opening. Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100 ug/ml. Dissolve the Lyophilized protein in ddH2O. Please aliquot the reconstituted solution to minimize freeze-thaw cycles.
- Tested applications:Bioassay
Specifications
About this item
Ganglioside GM2 activator (GM2A) is a small glycolipid transport protein which acts as a substrate specific co-factor for the lysosomal enzyme beta -hexosaminidase A (HEXB). HEXB together with GM2A, catalyses the degradation of the ganglioside GM2, and other molecules containing terminal N-acetyl hexosamines. GM2A accommodate several single chain phospholipids and fatty acids, is a lipid transfer protein that stimulates the enzymatic processing of gangliosides, and also T-cell activation through lipid presentation. It extracts single GM2 molecules from membranes and presents them in soluble form to beta-hexosaminidase A for cleavage of N-acetyl-D-galactosamine and conversion to GM3.
Fusion-Tag: C-6 His tag
This recombinant protein can be used for biological assays. For research use only.