ML-9

Supplier: Abcam

Broad spectrum ATP-competitive protein kinase inhibitor (Ki values are 32, 4, and 54 μM for PKA, MLCK, and PKC respectively). Ca²+ channel blocker. Shows vasorelaxant effects in vivo.

Supplier: Enzo Life Sciences

Selective inhibitor of MLC kinase (Ki=3.8 µM). Inhibits insulin-stimulated 2-deoxyglucose transport and PP-1 activation in adipocytes, possibly via an effect on MAP kinase or its activation. Useful PKB inhibitor (IC50=10-50 µM). Also known to inhibit PKA (IC50=20 µM) and S6 kinase (IC50=50 µM). Does not inhibit PI 3-kinase.

Supplier: Apollo Scientific

ML-9

Supplier: Apollo Scientific

Inhibits the catalytic activities of several protein linases competitively with respect to ATP. Also found to be a new type of vascular relaxant.