Process debottlenecking in buffer and media prep using enhanced raw material release/delivery strategies

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Higher titers in monoclonal antibody processes and newer cell & gene therapy products have introduced various new technologies into the biopharma market. While these new technologies have furthered the field as a whole they have also generated several new challenges in raw material management from a regulatory, quality and supply chain standpoint.

Typical biologic manufacturing consumes hundreds of raw materials including media, supplements, single-use systems, process chemicals, filters, resins, and excipients. Buffers are one of the largest constituents by volume used in the production of most modern biopharmaceutical products.

This presentation will give an overview of innovative new technologies like single use powder packaging and in-line dilution which can help reduce facility footprint, labor hours and overall cost-of-goods.

This presentation took place as part of 12th Annual Bioprocessing Summit on Thursday, 20th August 2020.

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Presented by:

Dr. Pranav Vengsarkar

Manager, Research & Development – Biopharma Production

Pranav Vengsarkar, Ph.D., is Manager, Process Development at Avantor, focused on product and process development for new cGMP products and excipients, and development and design of single-use raw material delivery systems. Pranav holds a Bachelor of Chemical Engineering degree from ICT, Mumbai and a Ph.D. in Chemical Engineering from Auburn University.

Avantor®, a Fortune 500 company, is a leading global provider of mission-critical products and services to customers in the biopharma, healthcare, education & government, and advanced technologies & applied materials industries. Our portfolio is used in virtually every stage of the most important research, development and production activities in the industries we serve. One of our greatest strengths comes from having a global infrastructure that is strategically located to support the needs of our customers. Our global footprint enables us to serve more than 225,000 customer locations and gives us extensive access to research laboratories and scientists in more than 180 countries. We set science in motion to create a better world.