Novel Purification Technologies and Approaches to Maximize Speed, Efficiency and Process Optimization

Register & watch

Over the past several years, significant progress has been made to increase upstream process titers, thus creating a strain on existing downstream purification technologies. Although implementation of continuous unit operations has provided some relief, downstream processing still presents a major bottleneck in the production of therapeutic antibodies.

In this presentation, we will demonstrate an integrated downstream purification process to enable significant removal of critical impurities. Through use of an affinity chromatography that possesses high dynamic binding capacities of greater than 60 g/L, we have obtained antibodies with increased purity while reducing overall process time.

Furthermore, by using select additives during process chromatography, we demonstrate this process can be fine-tuned to enhance target antibody selectivity by removing host cell protein impurities and aggregates. When used in conjunction these technologies represent a highly efficient process to obtain monoclonal antibodies for use as therapeutics.

This presentation was given during Bioprocess International and Cell & Gene Therapy Asia Digital Week, April 5 - 8, 2021

Register & watch

Presented by:

Dr. Jungmin Oh

Manager, New Product Development

In her current role, Jungmin leads product and process development projects with multiple biopharmaceutical industry partners, including customized product development for cell and gene therapy customers. She holds a MS and Ph.D. in chemical engineering, specializing in the optimization of a continuous chromatography system.

Avantor®, a Fortune 500 company, is a leading global provider of mission-critical products and services to customers in the biopharma, healthcare, education & government, and advanced technologies & applied materials industries. Our portfolio is used in virtually every stage of the most important research, development and production activities in the industries we serve. One of our greatest strengths comes from having a global infrastructure that is strategically located to support the needs of our customers. Our global footprint enables us to serve more than 225,000 customer locations and gives us extensive access to research laboratories and scientists in more than 180 countries. We set science in motion to create a better world.