Key challenges and potential solutions for eliminating bottlenecks and optimizing biopharma downstream processes

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Finding efficiencies across downstream processing steps and cost-effectively aligning the productivity of downstream production with upstream yields require complex analysis and optimisation.

This presentation elaborates on the key aspects of downstream processing, looking at different areas where improvements by new techniques and new technologies could be made, from current process chromatography technologies, new powder and liquid handling strategies to raw material data analysis.

This presentation was given during Bioprocessing Summit Virtual, March 16–17, 2021.

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Presented by:

Willie Hesselink

Willie Hesselink is a Senior Technical Application Project Manager at Avantor. Prior to this role, he was a R&D Manager at Avantor Performance Materials in Deventer, Netherlands.

Willie brings over 20 years of industrial expertise in the research and development of raw materials and excipients used in the different steps of biopharmaceutical processes. In his current role working within Avantor's biopharma production business unit, he has lead many process optimization and cost reduction projects in collaboration with customers. Willie holds a B.Sc. in analytical chemistry from the Saxion University of Applied Sciences in Enschede, Netherlands.

Avantor®, a Fortune 500 company, is a leading global provider of mission-critical products and services to customers in the biopharma, healthcare, education & government, and advanced technologies & applied materials industries. Our portfolio is used in virtually every stage of the most important research, development and production activities in the industries we serve. One of our greatest strengths comes from having a global infrastructure that is strategically located to support the needs of our customers. Our global footprint enables us to serve more than 225,000 customer locations and gives us extensive access to research laboratories and scientists in more than 180 countries. We set science in motion to create a better world.