Originally developed to target infectious diseases, new vaccine concepts now also focus on immune-oncology applications. In turn, this is leading to the growing use of processing applications employing primary cells or cell lines.
Avantor® supplies a wide range of cGMP chemicals and excipients, sera and single-use solutions for vaccine development and manufacturing, including solutions that support COVID-19 vaccines.
From the early discovery phase through product development, pre-clinical, scale-up and commercial vaccine manufacturing, we combine our in-depth understanding of the ways that diverse chemicals perform in cell culture systems with our broad portfolio of products to support your team in maintaining the integrity and activity of vaccine.
Vaccine manufacturing: COVID-19 and beyond
Nandu Deorkar, Vice President of R&D, Biopharma Production at Avantor, shares lessons we can learn from the industry’s historic ramp-up from research to manufacturing.
Solutions for every stage of vaccine manufacturing workflow
Optimal production of vaccines is achieved in mammalian expression and insect systems using cell lines that are anchorage-dependent or suspension enabled. Our systems include culture flasks and shaker platforms, roller bottles and roller bottle racks, sterile cell factories and microcarriers to allow for the culture of cell lines in larger bioreactors. We also offer media components with enriched growth supplements so that you can design your own formulations.
During downstream steps for vaccine concentration and clarification it is critical that vaccine purity, potency and consistency be maintained. Our highly stable, low-pH, low salt/high salt, equilibration and elution buffers—as well as individual buffer components—offer ideal performance. Additionally, Avantor J.T.Baker® brand BAKERBOND™ process chromatography media increases product yield by improving the efficiency of purification processes and enhances selectivity by removing closely related impurities. We also provide services that help optimize the efficiency of your downstream processing steps.
Progressing from the drug substance to the final injectable drug product, Avantor offers the required finished packaging vials and stoppers, as well as our industry-leading excipient product line including stabilizers and preservatives, that meet your team’s stringent requirements.
As an open architecture single-use manufacturer, Avantor supports every stage of your vaccine development and manufacturing process with single-use technologies for aseptic fluid-handling, storage and transfer. Single-use systems including the Avantor OmniTop Sample Tubes® Sampling Manifold Platform can be customized to match your sampling plan to ensure reliable sampling while maintaining an aseptic environment.
Maintaining aseptic conditions during the manufacturing or down packing process is part of managing your risk. We offer products from industry-leading manufacturers and support from our teams of specialists with the technical and industry experience to recommend the best solutions that meet your needs.
Explore our products for vaccine manufacturing
Optimize your vaccine manufacturing workflow with innovative solutions that help you achieve the reliability and sustainability you need in the development, scale-up and production of your vaccine. Explore our portfolio of cGMP chemicals, single-use solutions, sera and more on vwr.com.
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