Vaccines

Maximizing process quality and integrity

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Solutions for vaccine manufacturing

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Vaccine manufacturing: COVID-19 and beyond

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Originally developed to target infectious diseases, new vaccine concepts now also focus on immune-oncology applications. In turn, this is leading to the growing use of processing applications employing primary cells or cell lines.

Avantor® supplies a wide range of cGMP chemicals and excipients, sera and single-use solutions for vaccine development and manufacturing, including solutions that support COVID-19 vaccines.

From the early discovery phase through product development, pre-clinical, scale-up and commercial vaccine manufacturing, we combine our in-depth understanding of the ways that diverse chemicals perform in cell culture systems with our broad portfolio of products to support your team in maintaining the integrity and activity of vaccine.

Vaccine manufacturing: COVID-19 and beyond

Nandu Deorkar, Vice President of R&D, Biopharma Production at Avantor, shares lessons we can learn from the industry’s historic ramp-up from research to manufacturing.

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Solutions for every stage of vaccine manufacturing workflow

Upstream processing

Optimal production of vaccines is achieved in mammalian expression and insect systems using cell lines that are anchorage-dependent or suspension enabled. Our systems include culture flasks and shaker platforms, roller bottles and roller bottle racks, sterile cell factories and microcarriers to allow for the culture of cell lines in larger bioreactors. We also offer media components with enriched growth supplements so that you can design your own formulations.

Downstream purification

During downstream steps for vaccine concentration and clarification it is critical that vaccine purity, potency and consistency be maintained. Our highly stable, low-pH, low salt/high salt, equilibration and elution buffers—as well as individual buffer components—offer ideal performance. Additionally, Avantor J.T.Baker® brand BAKERBOND™ process chromatography media increases product yield by improving the efficiency of purification processes and enhances selectivity by removing closely related impurities. We also provide services that help optimize the efficiency of your downstream processing steps.

Final fill

Progressing from the drug substance to the final injectable drug product, Avantor offers the required finished packaging vials and stoppers, as well as our industry-leading excipient product line including stabilizers and preservatives, that meet your team’s stringent requirements.

Single-use solutions

As an open architecture single-use manufacturer, Avantor supports every stage of your vaccine development and manufacturing process with single-use technologies for aseptic fluid-handling, storage and transfer. Single-use systems including the Avantor OmniTop Sample Tubes® Sampling Manifold Platform can be customized to match your sampling plan to ensure reliable sampling while maintaining an aseptic environment.

Environmental control

Maintaining aseptic conditions during the manufacturing or down packing process is part of managing your risk. We offer products from industry-leading manufacturers and support from our teams of specialists with the technical and industry experience to recommend the best solutions that meet your needs.

Explore our products for vaccine manufacturing

Optimize your vaccine manufacturing workflow with innovative solutions that help you achieve the reliability and sustainability you need in the development, scale-up and production of your vaccine. Explore our portfolio of cGMP chemicals, single-use solutions, sera and more on vwr.com.

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mRNA: Advancing vaccine technology

mRNA uses information in genes to create a blueprint for making proteins. Learn how Avantor supports the mRNA workflow.

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Avantor®, a Fortune 500 company, is a leading global provider of mission-critical products and services to customers in the biopharma, healthcare, education & government, and advanced technologies & applied materials industries. Our portfolio is used in virtually every stage of the most important research, development and production activities in the industries we serve. One of our greatest strengths comes from having a global infrastructure that is strategically located to support the needs of our customers. Our global footprint enables us to serve more than 225,000 customer locations and gives us extensive access to research laboratories and scientists in more than 180 countries. We set science in motion to create a better world.