Recombinant proteins

Optimizing recombinant protein manufacturing with advanced solutions.

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Recombinant Protein Production

Recombinant proteins are manufactured using microbial (E. coli) expression systems. Multiple protein expression, aggregation, and filtration steps are required to yield protein-based therapeutic substances such as insulin, erythropoietin, and enzymes.

From upstream to downstream purification, through final fill, Avantor® partners with your team to help you achieve reliable results. We combine our extensive experience with a broad range of products that include cGMP fermentation materials to support cell growth, excipients, chromatography media to aid in recombinant protein purification, and single-use solutions to maximize the productivity of your bioprocessing systems.

Charting the rise of single-use

Single-use systems have come a long way and are used in the application of all biologics, from recombinant proteins to mAbs. Avantor subject matter experts discuss biopharma’s experience with the technology so far – and consider why it has become a popular choice for producing new drugs.

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Recombinant protein manufacturing flow

Upstream processing

Whether your fermentation media are animal-based materials or “animal-free,” our fermentation products — such as Avantor J.T.Baker® IPTG used during microbial fermentation to induce the expression of recombinant proteins — support cell growth and productivity while meeting the required quality and performance parameters. We also provide centrifuges and reagents for primary recovery, concentration, and clarification process steps.

Downstream purification

Our industry-leading Avantor J.T.Baker® brand buffer product line and J.T.Baker® brand BAKERBOND™ chromatography resins, including the BAKERBOND® PROchievA™ recombinant protein A resin, are trusted for high performance in recombinant proteins manufacturing. Backed by more than four decades of chromatography experience, we also provide downstream optimization services, including:

  • Column packing
  • Process development support
  • Custom chromatography resins
  • Column cleaning and storage recommendations

Final fill

Avantor offers the required finished packaging vials and stoppers you need to progress from the drug substance to the final injectable drug product. We also carry an industry-leading excipient product line, including stabilizers and preservatives that meet stringent internal and external quality requirements.

Single-use solutions

Scale your recombinant protein production using our single-use components, assemblies, and systems. Our technical experts can collaborate with you to customize products to meet the specifications needed for your application.

Environmental control

Maintaining aseptic conditions during the manufacturing or down packing process is part of managing your risk. We offer products from industry-leading manufacturers and support from our teams of specialists who have the technical and industry experience to recommend the best solutions to meet your needs.

How Avantor® can help

At Avantor, we have a deep understanding of bioprocessing workflows and regulatory environments. Our global distribution network and wide range of services can help you develop more efficient recombinant protein manufacturing processes. We deliver high-quality products with our streamlined purchasing experience. Our commitment to quality and innovation is proven and emphasized at every scale, making us a trusted partner.

Start optimizing your process performance with our innovative products and solutions for recombinant protein production:

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Avantor®, a Fortune 500 company, is a leading global provider of mission-critical products and services to customers in the biopharma, healthcare, education & government, and advanced technologies & applied materials industries. Our portfolio is used in virtually every stage of the most important research, development and production activities in the industries we serve. Our global footprint enables us to serve more than 225,000 customer locations and gives us extensive access to research laboratories and scientists in more than 180 countries. We set science in motion to create a better world.