Recombinant proteins are manufactured using microbial (E. coli) expression systems. Multiple protein expression, aggregation and filtration steps are required to yield protein-based therapeutic substances such as insulin, erythropoietin and enzymes.
From upstream to downstream purification, through final fill, Avantor® partners with your team to help you achieve reliable results. We combine our extensive experience with a broad range of products that include: cGMP fermentation materials to support cell growth, excipients, chromatography media to aid in recombinant protein purification, and single-use solutions to maximize the productivity of your bioprocessing systems.
Charting the rise of single-use
Single-use systems have come a long way and are used in the application of all biologics, from recombinant proteins to mAbs. Avantor subject matter experts discuss biopharma’s experience with the technology so far – and consider why it has become a popular choice for producing new drugs.
Solutions for every stage of the recombinant protein manufacturing workflow
Whether your fermentation media are animal-based materials or “animal-free,” our fermentation products – such as Avantor J.T.Baker® IPTG used during microbial fermentation to induce the expression of recombinant proteins – support cell growth and productivity while meeting the required quality and performance parameters. We also provide centrifuges and reagents for primary recovery, concentration and clarification process steps.
Our industry-leading Avantor J.T.Baker® brand buffer product line and J.T.Baker® brand BAKERBOND™ chromatography resins, including the BAKERBOND® PROchievA™ recombinant protein A resin, are trusted for high performance in the manufacturing of recombinant proteins. Backed by more than four decades of chromatography experience, we also provide downstream optimization services including column packing, process development support, custom chromatography resins and column cleaning and storage recommendations.
Progressing from the drug substance to the final injectable drug product, Avantor offers the required finished packaging vials and stoppers, as well as an industry-leading excipient product line including stabilizers and preservatives, that meet stringent internal and external quality requirements.
Scale up your production using our single-use components, assemblies and systems. Our technical experts can collaborate with you to customize products to meet the specifications needed for your application.
Maintaining aseptic conditions during the manufacturing or down packing process is part of managing your risk. We offer products from industry-leading manufacturers and support from our teams of specialists with the technical and industry experience to recommend the best solutions that meet your needs.
Explore our products for recombinant protein manufacturing
Start optimizing your process performance with our innovative products and solutions for recombinant protein production:
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