recombinant proteins

Recombinant proteins

Advanced solutions for producing protein-based drugs

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Recombinant proteins are manufactured using microbial (E. coli) expression systems. Multiple, complex protein expression, aggregation and filtration steps are required to yield protein-based therapeutic materials such as insulin, erythropoietin and enzymes.

Avantor® offers a range of products to aid in recombinant protein manufacturing including cGMP fermentation products to support cell growth and a broad range of excipients to aid in recombinant protein purification.

Avantor combines extensive experience about the ways various chemistries perform in cell culture systems with practical insights on the ways our portfolio of chemistries, single-use systems, process chromatography media and final fill products can maximize the productivity of your bioprocessing systems—from upstream production to downstream purification through final fill.

Recombinant proteins workflow solutions

Upstream processing: Whether your fermentation media are animal-based materials or “animal-free,” our fermentation products support cell growth and productivity while meeting the required quality and performance parameters that allow for seamless transfer from R&D through pilot scale and full manufacture scale. We also provide centrifuges and reagents for primary recovery, concentration and clarification process steps.

Downstream purification: Avantor J.T.Baker® brand BAKERBOND™ chromatography resins have been used successfully in recombinant proteins manufacturing. Backed by more than 30 years of chromatography experience, developed products and services, we also provide services including column packing, process development support, custom chromatography resins and column cleaning and storage recommendations .

Final fill: Progressing from the drug substance to the final injectable drug product, Avantor offers the required final packaging vials and stoppers, as well as an industry-leading excipient product line including stabilizers and preservatives, that meet a number of stringent quality requirements.

Single-use solutions: Scale up your production using our single-use components, assemblies and systems. Our technical experts can collaborate with you to customize products to meet the specifications needed for your application.

Environmental control: Maintaining controlled aseptic conditions during the manufacturing or down packing process is part of managing your risk. We offer products from industry-leading manufacturers as well as a team of specialists with technical and industry experience who can recommend the best solutions to meet your needs.

Products for recombinant proteins manufacturing

Start optimizing your process performance with our innovative products and solutions for recombinant protein production:

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Avantor®, a Fortune 500 company, is a leading global provider of mission-critical products and services to customers in the biopharma, healthcare, education & government, and advanced technologies & applied materials industries. Our portfolio is used in virtually every stage of the most important research, development and production activities in the industries we serve. One of our greatest strengths comes from having a global infrastructure that is strategically located to support the needs of our customers. Our global footprint enables us to serve more than 225,000 customer locations and gives us extensive access to research laboratories and scientists in more than 180 countries. We set science in motion to create a better world.