Optimizing Upstream Biopharmaceutical Processing Through More Effective Insight and Control of Cell Culture Media and Supplement Attributes
Despite significant advances made in recent years to increase biologic yields as well as the intensity and consistency of these processes, there is still the potential for innovation in this area in order to reach more efficient production of therapeutic proteins. Finding new approaches to improve protein expression; developing more flexible, cost-effective and robust manufacturing processes that lead to higher yields; and solving the complex task of refolding proteins into their active state are among the challenges faced by the industry.
As cell culture processes are influenced by nutrients and trace elemental impurities, cell expansion steps requiring various media components can impact the overall process and result in a lower final product yield, higher amounts of product-related impurities and/or longer process time. With a better understanding of the properties of these media and supplements, process scientists can take steps to better manage the quality and consistency of their cell culture raw materials in order to minimize variability in the upstream process.
Authors
Claudia Berrón
Senior Vice President, Clinical Services
Claudia Berrón is Avantor’s Senior Vice President, Clinical Services. Prior to this, she was Senior Vice President, Business Development and Commercial Operations for our Biopharma Production business unit. Claudia has over two decades of experience in strategic marketing, covering ideation, value proposition strategies, market segmentation and planning through product and services launch into market. She has been with Avantor since 2015.
Claudia holds an MBA from the University of North Carolina Kenan-Flagler Business School and a bachelor’s degree from Monterrey Institute of Technology in Mexico City.
Dr. Nandu Deorkar
Vice President, Research & Development – Biopharma Production
During his more than 25-year career in materials technology research & development, Dr Deorkar has worked on various aspects of chemical/polymer R&D, drug development, formulation, drug delivery technologies, process development, and technology transfer. Dr Deorkar earned his PhD in chemistry from the Indian Institute of Technology, Bombay, and his MBA from Fairleigh Dickinson University, New Jersey (USA).
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