Monoclonal antibodies (mAbs)

Optimize your mAbs bioprocessing performance with industry-leading solutions

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Solutions for mAbs manufacturing

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Improving mAb manufacturing productivity by optimizing buffer and media prep process flow

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Monoclonal antibodies (mAbs) are at the forefront of the biological products market. They will continue to lead resource investment in the biopharmaceutical industry to help provide innovative therapeutic solutions for immune-oncology and immunotherapy.

Avantor® offers an industry-leading portfolio of upstream, downstream, and drug product bioprocessing solutions. Our solutions help you maintain mAbs quality, activity, and stability throughout the entire process.

Improving mAb manufacturing productivity

Flexible, cost-efficient infrastructure and on-time delivery of buffers are required to meet process demands in mAbs manufacturing. Single-use delivery systems, in powder or liquid form, can help accomplish these goals while reducing the risk of contamination, among other benefits.

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Solutions for the mAbs manufacturing workflow

We match our supply chain of products for mammalian expression systems to the complexity of mAbs manufacturing – from process development and scale-up through commercial manufacturing to final fill.

Upstream processing

Our fully characterized products for upstream processing of mAbs are designed to support cell growth, consistency, and productivity while meeting the required quality and performance parameters. Avantor’s commitment to using an open architecture design of single-use assemblies allows the seamless transfer from process development to pilot scale and final commercial manufacturing.

Downstream purification

Our industry-leading Avantor J.T.Baker® brand buffer product line and J.T.Baker® BAKERBOND™ chromatography resins, including the BAKERBOND® PROchievA™ recombinant protein A resin, are trusted for high performance in mAbs manufacturing. We also provide downstream optimization services, including column packing and process development support to streamline your operations.

Final fill

Avantor offers the highest purity excipients you need to progress from drug substance to final drug product, including adjuvants, stabilizers, preservatives, and bulking agents used in drug product formulation to minimize drug product degradation. We also offer packaging vials and stoppers that meet stringent internal and external quality requirements.

Single-use solutions

Avantor supports every stage of your mAbs manufacturing process with single-use technologies, including components, connectors, and assemblies for aseptic fluid handling and storage in upstream, downstream, fill and finish process steps.

Environmental control

Maintaining aseptic conditions during the manufacturing or down packing process is part of managing your risk. We offer products from industry-leading manufacturers and support from our teams of specialists who have the technical and industry experience to recommend the best solutions to meet your needs.

How can we help?

Avantor’s solutions, combined with our experience and insights into bioprocessing optimization, can help biopharma manufacturers increase mAb titers, mAb fragments that can be manufactured in other expression systems, multiple target specificity for mAbs, and the development of Antibody-Drug Conjugates (ADCs) that deliver drugs to targeted cancer cells.

Our portfolio includes mission-critical products and services that support every stage of your process, from monoclonal antibodies research to production. We have a global infrastructure that serves more than 225,000 customer locations worldwide. Let us improve your bioproduction efficiencies so you can focus on scientific breakthroughs.

Explore our mAbs manufacturing products

Start optimizing your process performance with our innovative products and single-use solutions for mAbs production:

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Avantor®, a Fortune 500 company, is a leading global provider of mission-critical products and services to customers in the biopharma, healthcare, education & government, and advanced technologies & applied materials industries. Our portfolio is used in virtually every stage of the most important research, development and production activities in the industries we serve. Our global footprint enables us to serve more than 225,000 customer locations and gives us extensive access to research laboratories and scientists in more than 180 countries. We set science in motion to create a better world.