monoclonal antibodies

Monoclonal antibodies (mAbs)

Optimizing mAbs bioprocessing performance

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Monoclonal antibodies (mAbs) lead all biological marketed products and will continue to lead the biopharmaceutical industry investments to provide therapeutic solutions for immune-oncology or immunotherapy. Avantor® offers an industry-leading portfolio of solutions for upstream, downstream and drug product bioprocessing that maintain mAbs quality, activity and stability throughout the entire process.

Combined with Avantor’s insights into bioprocess optimization, we can help biopharma manufacturers increase mAb titers, mAb fragments that can be manufactured in other expression systems, multiple target specificity for mAbs and the development of Antibody-Drug Conjugates (ADCs) that deliver drugs to targeted cancer cells.

mAbs workflow solutions

We match our supply chain of products for mammalian expression systems to meet the complexity of mAbs manufacturing—from process development and scale-up, through commercial manufacturing to final fill.

Upstream processing: Fully characterized products offered for upstream processing for mAbs are designed to support cell growth, consistency and productivity while meeting the required quality and performance parameters. Avantor’s commitment to using an open architecture design of single-use assemblies allows for seamless transfer from process development to pilot scale, and  final commercial manufacturing.

Downstream purification: In the manufacturing of mAbs, Avantor J.T.Baker® brand BAKERBOND™ chromatography resins are proven to reduce total purification steps while improving purity and yield. Our industry-leading J.T.Baker and VWR® Bioprocessing buffer product lines cover all your buffer requirements from column equilibration, protein elution, to buffers which support protein solutions for various process hold steps.

Final fill: To progress from drug substance to the final injectable drug product, Avantor offers the highest purity excipients used in drug product formulation to minimize drug product degradation, including adjuvants, stabilizers, preservatives and bulking agents. We also offer packaging vials and stoppers that meet a number of stringent quality requirements.

Single-use solutions: Avantor can support every stage of your mAbs manufacturing process with standard and custom single-use components, connections and assemblies to support sterile fluid transfer in upstream, downstream, and fill and finish process steps.

Environmental control: Maintaining controlled aseptic conditions during the manufacturing or down packing process is part of managing your risk. We offer products from industry-leading manufacturers and support from our teams of specialists with technical and industry experience who can recommend the best solutions to meet your needs.

Products for mAbs manufacturing

Start optimizing your process performance with our innovative products and single-use solutions for mAbs production:

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Avantor®, a Fortune 500 company, is a leading global provider of mission-critical products and services to customers in the biopharma, healthcare, education & government, and advanced technologies & applied materials industries. Our portfolio is used in virtually every stage of the most important research, development and production activities in the industries we serve. One of our greatest strengths comes from having a global infrastructure that is strategically located to support the needs of our customers. Our global footprint enables us to serve more than 225,000 customer locations and gives us extensive access to research laboratories and scientists in more than 180 countries. We set science in motion to create a better world.