Monoclonal antibodies (mAbs)

Optimizing mAbs bioprocessing performance

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Solutions for mAbs manufacturing


Improving mAb manufacturing productivity by optimizing buffer and media prep process flow

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Monoclonal antibodies (mAbs) are at the forefront of the biological products market and will continue to lead resource investment into the biopharmaceutical industry in order to provide innovative therapeutic solutions for immune-oncology and immunotherapy. Avantor® offers an industry-leading portfolio of solutions for upstream, downstream and drug product bioprocessing that maintain mAbs quality, activity and stability throughout the entire process.

Avantor’s solutions, combined with our experience with – and insights into – bioprocessing optimization can help biopharma manufacturers increase mAb titers, mAb fragments that can be manufactured in other expression systems, multiple target specificity for mAbs and the development of Antibody-Drug Conjugates (ADCs) that deliver drugs to targeted cancer cells.

Improving mAb manufacturing productivity

Flexible, cost-efficient infrastructure and on-time delivery of buffers are required to meet process demands in mAbs manufacturing. Single-use delivery systems, in powder or liquid form, can help accomplish these goals while reducing the risk of contamination, among other benefits.

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Solutions for every stage of the mAbs manufacturing workflow

We match our supply chain of products for mammalian expression systems to the complexity of mAbs manufacturing – from process development and scale-up, through commercial manufacturing to final fill.

Upstream processing

Fully characterized products offered for upstream processing of mAbs are designed to support cell growth, consistency and productivity while meeting the required quality and performance parameters. Avantor’s commitment to using an open architecture design of single-use assemblies allows for seamless transfer from process development to pilot scale, and final commercial manufacturing.

Downstream purification

Our industry-leading Avantor J.T.Baker® brand buffer product line and J.T.Baker® BAKERBOND™ chromatography resins, including the BAKERBOND® PROchievA™ recombinant protein A resin, are trusted for high performance in mAbs manufacturing. Backed by decades of chromatography experience, we also provide downstream optimization services including column packing and process development support to streamline your operations.

Final fill

To progress from drug substance to final drug product, Avantor offers the highest purity excipients including adjuvants, stabilizers, preservatives and bulking agents used in drug product formulation to minimize drug product degradation. We also offer packaging vials and stoppers that meet stringent internal and external quality requirements.

Single-use solutions

Avantor can support every stage of your mAbs manufacturing process with single-use technologies including components, connectors and assemblies for aseptic fluid handling and storage in upstream, downstream, fill and finish process steps.

Environmental control

Maintaining aseptic conditions during the manufacturing or down packing process is part of managing your risk. We offer products from industry-leading manufacturers and support from our teams of specialists who have the technical and industry experience to recommend the best solutions to meet your needs.

Explore our products for mAbs manufacturing

Start optimizing your process performance with our innovative products and single-use solutions for mAbs production:

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Avantor®, a Fortune 500 company, is a leading global provider of mission-critical products and services to customers in the biopharma, healthcare, education & government, and advanced technologies & applied materials industries. Our portfolio is used in virtually every stage of the most important research, development and production activities in the industries we serve. One of our greatest strengths comes from having a global infrastructure that is strategically located to support the needs of our customers. Our global footprint enables us to serve more than 225,000 customer locations and gives us extensive access to research laboratories and scientists in more than 180 countries. We set science in motion to create a better world.