Gene therapies

Resources to help solve complex gene therapies workflows

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Solutions for cell and gene therapy manufacturing

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Advancing gene therapy scale-up & manufacturing

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Gene therapies offer the potential to provide significant—and possibly curative—benefits to patients with genetic or acquired diseases. Through either the direct expression of a therapeutic protein or by restoring the expression of an under-expressed protein, gene therapy uses vectors to deliver gene-based drugs and therapeutic loads to the patient.

Maintaining the integrity and activity of the gene therapy product during upstream and downstream purification through to final fill is complex. We offer a broad range of cGMP chemicals and single-use technologies to help you develop gene therapies that can reach patients faster—from cell culture components, fermentation media and supplements to growth factors, reagents and excipients.

Additionally, our range of single-use products enable aseptic fluid transfer and storage, offering the flexibility and speed your team needs to pivot research projects and scale-out novel therapies quickly.

Advancing gene therapy by solving challenges in scale-up & manufacturing

Latest Q&A with Ger Brophy, Avantor Executive Vice President, Biopharma Production with new insight on gene therapy

Solutions for every stage of the gene therapy manufacturing workflow

Upstream processing

Optimal generation of gene therapy vectors is achieved with Avantor’s non-viral transfection and viral transduction products. Our cell culture systems and single-use solutions support process development, scale-up and full manufacturing. We offer a variety of transfection and electroporation products, viral vector generation kits, animal sera, single-use products and sterile cell factories.

Downstream purification

Avantor J.T.Baker® brand cGMP chemicals and BAKERBOND™ chromatography resins have been used successfully in commercial and clinical manufacturing of protein therapeutics for decades. We also offer our expertise in chromatography and downstream process optimization with services including column packing, process development support, custom chromatography resins and column cleaning and storage recommendations.

Final fill

Progressing from drug substance to a final drug product requires the correct packaging vials and stoppers, as well as a broad range of excipients that meet a number of stringent quality requirements. Avantor partners with you to match your therapy with appropriate products and materials.

Single-use solutions

Our single-use solutions are designed for flexibility and versatility in aseptic fluid handling across the upstream, downstream and final-fill steps of producing gene therapies. Solutions for the gene therapy workflow include our proprietary Avantor OmniTop Sample Tubes® Adjustable Volume Sampling System (AVSS), which is designed to aseptically draw a precise small sample volume from your most critical applications.

Environmental control

Maintaining aseptic conditions during the manufacturing or down packing process is part of managing your risk. We offer products from industry-leading manufacturers and support from our teams of specialists with the technical and industry experience to recommend the best solutions that meet your needs.

Explore our products for gene therapy manufacturing

Optimize your gene therapy workflow with our innovative products and solutions. Explore our portfolio of cGMP chemicals, single-use solutions, sera and more on vwr.com.

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Avantor®, a Fortune 500 company, is a leading global provider of mission-critical products and services to customers in the biopharma, healthcare, education & government, and advanced technologies & applied materials industries. Our portfolio is used in virtually every stage of the most important research, development and production activities in the industries we serve. One of our greatest strengths comes from having a global infrastructure that is strategically located to support the needs of our customers. Our global footprint enables us to serve more than 225,000 customer locations and gives us extensive access to research laboratories and scientists in more than 180 countries. We set science in motion to create a better world.