Gene therapies

Discover trusted resources to help solve complex gene therapies workflows.

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Solutions for cell and gene therapy manufacturing


Advancing gene therapy scale-up & manufacturing

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Gene Therapy Research

Gene therapies can provide significant — and possibly curative —benefits to patients who have genetic or acquired diseases. Through the direct expression of a therapeutic protein or by restoring the expression of an under-expressed protein, gene therapy uses vectors to deliver gene-based drugs and therapeutic loads to patients.

It is a complex process to maintain the integrity and activity of the gene therapy product during upstream and downstream purification to final fill. We offer a broad range of cGMP chemicals and single-use technologies to help you develop gene therapies that can reach patients faster, from cell culture components, fermentation media, and supplements to growth factors, reagents, and excipients.

Our range of single-use products enables aseptic fluid transfer and storage, offering the flexibility and speed your team needs to quickly pivot research projects and scale novel therapies.

Advancing gene therapy by solving challenges in scale-up & manufacturing

Latest Q&A with Ger Brophy, Avantor Executive Vice President, Biopharma Production with new insight on gene therapy

Gene therapy manufacturing

At Avantor, we provide solutions for every stage of your cell and gene therapies, so you can focus on gene therapy research and deliver life-saving treatments.

Upstream processing

You can achieve the optimal generation of gene therapy vectors with Avantor’s non-viral transfection and viral transduction products. Our cell culture systems and single-use solutions support process development, scale-up, and complete manufacturing. We offer a variety of gene therapy products, including:

  • Transfection and electroporation products
  • Viral vector generation kits
  • Animal sera
  • Single-use products
  • Sterile cell factories

Downstream purification

Avantor J.T.Baker® brand cGMP chemicals and BAKERBOND™ chromatography resins have been successfully used in commercial and clinical manufacturing of protein therapeutics for decades. We offer our expertise in chromatography and downstream process optimization with services including:

  • Column packing
  • Process development support
  • Custom chromatography resins
  • Column cleaning
  • Storage recommendations

Final fill

To progress from a drug substance to a final drug product requires the correct packaging vials and stoppers and a broad range of excipients that meet many stringent quality requirements. Avantor partners with you to match your therapy with appropriate gene therapy products and materials.

Single-use solutions

Our single-use solutions are designed for flexibility and versatility in aseptic fluid handling across the upstream, downstream, and final-fill steps of producing gene therapies. Solutions for the gene therapy workflow include our proprietary Avantor OmniTop Sample Tubes® Adjustable Volume Sampling System (AVSS), which is designed to aseptically draw a precise small sample volume from your most critical applications.

Environmental control

Maintaining aseptic conditions during the manufacturing or down packing process is part of managing your risk. We offer products from industry-leading manufacturers and support from our teams of specialists who have the technical and industry experience to recommend the best solutions to meet your needs.

Gene therapy products

Optimize your workflow with our innovative gene therapy products and solutions. Avantor provides compliant materials that include:

  • Plasmid DNA production products
  • Cell culture media and sera
  • Plasmid transfection and T-cell transduction reagents
  • Expansion and purification chemicals
  • High purity and excipients
  • Single-use fluid connectivity, sampling, and sterile transfer

We also offer tailored innovative solutions to help you solve process challenges. These include:

  • Customized single-use solutions
  • Custom-packaged buffers and excipients
  • Customized formats for media, sterile solutions, excipients, and preservation reagents

Explore our portfolio of cGMP chemicals, single-use solutions, sera, and more on

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Avantor®, a Fortune 500 company, is a leading global provider of mission-critical products and services to customers in the biopharma, healthcare, education & government, and advanced technologies & applied materials industries. Our portfolio is used in virtually every stage of the most important research, development and production activities in the industries we serve. Our global footprint enables us to serve more than 300,000 customer locations and gives us extensive access to research laboratories and scientists in more than 180 countries. We set science in motion to create a better world.