Gene therapies

Resources to help solve complex gene therapies workflows

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Gene therapies offer the potential to provide significant—and possibly curative—benefits to patients with genetic or acquired diseases. Through either the direct expression of a therapeutic protein or by restoring the expression of an under-expressed protein, gene therapy uses vectors for gene-based drugs and therapeutic loads to the patient.

Maintaining the integrity and activity of the gene therapy product during upstream and downstream purification through final fill is endlessly complex. As an open architecture, single-use provider, Avantor® can help simplify and support your gene therapy development and manufacturing processes. We offer a broad range of solutions to help you develop gene therapies that can reach patients faster—from cell culture components, fermentation media and supplements, growth factors, reagents and excipients and single-use products to enable aseptic fluid transfer and closed-system cell culture.

Gene therapy workflow solutions

Upstream processing: Optimal generation of gene therapy vectors is achieved with Avantor’s non-viral transfection and viral transduction products. Our culture systems and single-use solutions support processes development, scale-up and full manufacturing. We offer a variety of transfection and electroporation products, viral vector generation kits, animal sera, single-use products and sterile cell factories.

Downstream purification: Avantor J.T.Baker® brand BAKERBOND™ chromatography resins have been used successfully in commercial and clinical manufacturing of protein therapeutics. Backed by more than 30 years of chromatography experience, developed products and services, we also provide services including column packing, process development support, custom chromatography resins and column cleaning and storage recommendations.

Final fill: Progressing from the drug substance to the final injectable drug product requires final packaging vials and stoppers, as well as a broad range of excipients that meet a number of stringent quality requirements.

Single-use solutions: Our single-use solutions, including our proprietary Avantor OmniTop Sample Tubes® Adjustable Volume Sampling System (AVSS) is designed to aseptically draw an exact small sample volume from your most critical applications. The system reduces operator variability and eliminates sampling hold up and waste volumes, enhancing your manufacturing productivity by increasing overall product yields.

Environmental control: Maintaining controlled aseptic conditions during the manufacturing or down packing process is part of managing your risk. We offer products from industry-leading manufacturers and support from our teams of specialists with technical and industry experience who can recommend the best solutions to meet your needs.

Products to help advance gene therapy manufacturing

Start optimizing your process performance with our innovative products and solutions for gene therapy production:

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Advancing gene therapy by solving challenges in scale-up & manufacturing

Latest Q&A with Ger Brophy, Avantor Executive Vice President, Biopharma Production with new insight on gene therapy

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Avantor®, a Fortune 500 company, is a leading global provider of mission-critical products and services to customers in the biopharma, healthcare, education & government, and advanced technologies & applied materials industries. Our portfolio is used in virtually every stage of the most important research, development and production activities in the industries we serve. One of our greatest strengths comes from having a global infrastructure that is strategically located to support the needs of our customers. Our global footprint enables us to serve more than 225,000 customer locations and gives us extensive access to research laboratories and scientists in more than 180 countries. We set science in motion to create a better world.