Cell therapies
Advance every stage of your bioprocessing workflow with our cell therapy solutions.
Cell therapies such as CAR-T and TCR-T offer transformative outcomes for challenging diseases. Recent cell therapy approvals and the growing number of clinical trials are accelerating the process from discovery through clinical trials to commercial manufacturing and delivery.
Cell Therapy Solutions from Avantor®
Avantor® offers a broad range of cell therapy research and manufacturing solutions, including:
- cGMP chemicals
- Sera and reagents
- Single-use solutions
- Upstream processing
- Downstream purification
- Final fill
- Environmental control
Our broad portfolio of products and services helps researchers and manufacturers develop and scale novel cell therapies. Companies can rely on our in-depth research and process optimization knowledge to help them overcome obstacles they may face in cell therapy workflows.
We partner with you during the development phase to customize and provide ready-to-use, pre-weighed, and pre-packaged cGMP chemicals that fit your cell culture scale-up needs. We supply animal sera to enhance attachment and growth of adherent cells and cell culture components, fermentation media and supplements, growth factors, reagents, and excipients.
In addition, our single-use products enable aseptic fluid transfer and closed-system cell culture to help mitigate process contamination risk and add speed and flexibility to cell therapy manufacturing.
Innovation at Avantor
In the race to treat and cure disease, there is no room for error, and no time for delays. See our commitment to cell & gene therapy production in action.
Cell therapy manufacturing
Upstream processing
Cell therapies focus on maximum cell dose for delivery and the functionality of the cells and tissues being administered rather than on maximum titers and protein quality,
Avantor has optimized our cell culture supplements, cell dissociation reagents, and other products to help you achieve your goals in upstream processing and protect the quality of your final cell product.
Downstream purification
Processes for downstream purification of advanced cell therapies differ dramatically from other biologics. Our cell therapy solutions can help you successfully execute the complex steps required to obtain the final cell dose with the required quality parameters.
We help you streamline activities such as centrifugation — or alternative methods such as counter-flow centrifugation — for debris removal, washing and concentration of the cell dose, and filtration steps.
Final fill
Cell therapy drug products are configured based on the delivery mechanism of the cells or tissues. Avantor works with you to select and supply the best excipients to prepare the cell dose.
We offer various assays on drug substances and drug products to confirm:
- Product sterility
- Lack of contaminating mycoplasma
- Endotoxin levels
- Removal of viral contaminants
Fluid handling solutions
Our fluid handling solutions, including Avantor Masterflex® peristaltic pumps, tubing and single-use components, are custom designed for flexibility and versatility in aseptic fluid handling across the upstream, downstream, and final-fill steps of producing cell therapies.
Our proprietary Avantor Adjustable Volume Sampling System (AVSS) and Exact Volume Sampling System (EVSS) are designed to aseptically draw a precise small sample volume from your most critical applications. These single-use, closed system solutions eliminate the need for a biologic hood are available as standard products or are fully customizable to your exact specifications.
Environmental control
Maintaining aseptic conditions during the manufacturing or down packing process is part of managing your risk. We offer products from industry-leading manufacturers and support from our teams of specialists who have the technical and industry experience to recommend the best solutions to meet your needs.
Explore our products for cell therapy manufacturing
Optimize your cell therapy workflow with our innovative solutions. Explore our portfolio of cGMP chemicals, single-use solutions, sera, and more on vwr.com.
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Why choose Avantor
As a leading global supplier of mission-critical products and services, Avantor delivers everything needed for cell therapy research, development, and production. Our mission is to enable scientific breakthroughs and set science in motion to create a better world. We collaborate with scientists, educators, and innovators to help support their journeys.
Our global infrastructure allows us to support our customers’ needs wherever they are in the world. When you work with Avantor, you get a reliable partner who carries high-quality products and provides cost-effective services. Contact us to find out how we can support your next breakthrough.
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