cell therapies

Cell therapies

Solutions to advance bioprocessing for cell-based therapies

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Activated cell therapies such as CAR-T and TCR-T offer transformative outcomes for challenging diseases. Recent cell therapy approvals and the growing number of clinical trials are accelerating the process from discovery through clinical to commercial manufacturing and delivery.

Avantor® offers a broad range of cGMP chemicals, sera and reagents as well as single-use solutions to help researchers and manufacturers develop and scale up cell therapies. We supply animal sera to enhance attachment and growth of adherent cells and cell culture components, fermentation media and supplements, growth factors, reagents and excipients, and single-use use products to enable aseptic fluid transfer and closed-system cell culture.

We offer our in-depth research and process optimization knowledge to help overcome obstacles in cell therapy workflows, and can customize and provide ready to use pre-weight package size required for chemicals and serum to fit cell culture scale up needs. Additionally, we offer a selection of best-in-class cloud computing and AI/machine learning tools to help improve insights and productivity in R&D, clinical trials and manufacturing.

Cell therapy workflow solutions

Upstream processing: Rather than striving for maximum titers and protein quality, cell therapies focus on maximum cell dose for delivery and the functionality of the cells/tissues being administered. Avantor has optimized our cell culture supplements, cell dissociation reagents and other products for upstream processing to help cell therapy producers achieve those goals and protect the quality of the final cell product.

Downstream purification: Processes for downstream purification of advanced cell therapies differ dramatically from other biologics. Our cell therapy solutions can help you accomplish complex steps required to obtain the final cell dose with the required quality parameters, including centrifugation or alternative methods such as counter-flow centrifugation for removal of debris, washing and concentration of the cell dose, and depth and ultrafiltration using TFF options.

Final fill: Cell therapy drug products are configured based on the delivery mechanism of the cells or tissues. Avantor can work with you to select and supply the right excipients to prepare the cell dose. We also offer various assays on drug substances and drug products to confirm product sterility, lack of contaminating mycoplasma, endotoxin levels and confirmation that viral contaminants have been removed.

Single-use solutions: Our single-use solutions, including our proprietary Avantor OmniTop Sample Tubes® Adjustable Volume Sampling System (AVSS) is designed to aseptically draw an exact small sample volume from your most critical applications. The system reduces operator variability and eliminates sampling hold up and waste volumes, enhancing your productivity by increasing overall product yields. 

Environmental control: Maintaining controlled aseptic conditions during the manufacturing or down packing process is part of managing your risk. We offer products from industry-leading manufacturers and support from our teams of specialists with technical and industry experience who can recommend the best solutions to meet your needs.

Products to help advance cell therapy manufacturing

Start optimizing your process performance with our innovative products and solutions for cell therapy production:

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Avantor®, a Fortune 500 company, is a leading global provider of mission-critical products and services to customers in the biopharma, healthcare, education & government, and advanced technologies & applied materials industries. Our portfolio is used in virtually every stage of the most important research, development and production activities in the industries we serve. One of our greatest strengths comes from having a global infrastructure that is strategically located to support the needs of our customers. Our global footprint enables us to serve more than 225,000 customer locations and gives us extensive access to research laboratories and scientists in more than 180 countries. We set science in motion to create a better world.