Avantor hydration solutions
Buffer management strategies in downstream processing
Buffers play a significant role in biopharmaceutical manufacturing. They represent the major component by number and overall volume used in biopharma downstream processing steps. Buffer preparation makes up a substantial portion of a facility’s footprint and overall cost, labor requirements, and equipment.
That’s why Avantor® offers a wide range of buffer management solutions to help you save time and reduce expenses. We can help you resolve your buffer management challenges to help reduce your manufacturing footprint, save time, and reduce manufacturing expenses.
There are several ways to supply buffers and process liquids. One way is to manufacture buffers in-house with purified water that meets USP standards or water for injection (WFI) standards to hydrate powders in stainless steel or single-use tanks.
This method may be ideal for a large volume of stock solutions; these are resource-intensive activities that need significant infrastructure. That includes warehouse space for storing raw materials and a weighing and dispensing area.
Considering the complexity and cost of buffer preparation, using hydrated, premade liquid buffers and buffer concentrates can save time and resources and reduce overall buffer management costs.
Optimize Your Buffer Preparation Processes
Depending on the size of your biopharma manufacturing operations—whether you operate a large-scale biomanufacturing facility or a smaller operation—different approaches to resolve buffer management can be applied as stand-alone solutions or combined with other strategies to achieve workflow improvements. Among those approaches are:
- Ready-to-use cGMP buffer solutions
- Buffer concentrates, used with line dilution
- Buffer stock concentrates used in with buffer stock blending
By understanding and evaluating alternative buffer management strategies and the resources you’ll need to execute them, you can help ensure you have the tools necessary to remain competitive in today’s growing bioprocessing industry.
Improving mAb manufacturing productivity
It is common for biologics manufacturing processes to require hundreds of raw materials, ranging from media and media supplements, buffers, and salts to other process chemicals.
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Start optimizing your buffer management with options offered by Avantor.
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