GW5074 ≥98% (by TLC)
Supplier: ENZO LIFE SCIENCES
Potent and selective cell permeable inhibitor of cRAF1 kinase (IC50 = 9 nM) with 100-fold selectivity over CDK1, CDK2, c-src, ERK2, MEK, p38, Tie2, VEGFR2 and c-fm. A useful tool for assessing the involvement of the Ras/Raf-1/ERK pathway in various signaling pathways. Displays neuroprotective effects in vivo through a MEK-ERK and Akt-independent mechanism.
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A-3 hydrochloride ≥98% (by TLC)
Supplier: ENZO LIFE SCIENCES
Inhibitor of cAMP- and cGMP-dependent protein kinase (PKA, Ki=4.3µM and PKG, Ki=3.8µM), protein kinase C (PKC, Ki=47µM), casein kinase I and II, and myosin light chain kinase (MLCK, Ki=7.4µM).
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L-NASPA ≥98% (by TLC)
Supplier: ENZO LIFE SCIENCES
L-NASPA is an antagonist of LPA-induced platelet aggregation and chloride conductance in Xenopus oocytes. In human breast carcinoma MDA-MB231 cells it is a potent LPA agonist.
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SB202190 ≥98% (by TLC)
Supplier: ENZO LIFE SCIENCES
Cell permeable, potent and selective p38 MAP kinase inhibitor (IC50=30 nM). Inhibits p38α and ß, but not γ and δ isoforms. Does not inhibit ERK2 or other members of the MAP kinase family or their upstream activators. A useful tool for dissecting the role of p38 in signaling pathways. Induces apoptosis.
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DMOG ≥99% (by TLC)
Supplier: ENZO LIFE SCIENCES
DMOG is a cell permeable prolyl-4-hydroxylase inhibitor which upregulates HIF activity. HIF activation stimulates angiogenesis in several different models. DMOG also inhibits FIH (Factor Inhibiting HIF), an asparaginyl hydroxylase, which enhances the HIF response. It is active in vivo and attenuates myocardial injury in a rabbit ischemia reperfusion model (20mg/kg). Is expected to act pro-angiogenic.
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ML-9 ≥98% (by TLC)
Supplier: ENZO LIFE SCIENCES
Selective inhibitor of MLC kinase (Ki=3.8 µM). Inhibits insulin-stimulated 2-deoxyglucose transport and PP-1 activation in adipocytes, possibly via an effect on MAP kinase or its activation. Useful PKB inhibitor (IC50=10-50 µM). Also known to inhibit PKA (IC50=20 µM) and S6 kinase (IC50=50 µM). Does not inhibit PI 3-kinase.
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Anti-TMC6 Rabbit Polyclonal Antibody (APC (Allophycocyanin))
Supplier: US Biological
Anti-TMC6 Rabbit Polyclonal Antibody (APC (Allophycocyanin))
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Anti-TEC Rabbit Polyclonal Antibody (PE (Phycoerythrin))
Supplier: US Biological
Anti-TEC Rabbit Polyclonal Antibody (PE (Phycoerythrin))
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D-VLK-AMC [D-Val-Leu-Lys-AMC]
Supplier: AAT BIOQUEST
D-VLK-AMC is a sensitive, highly specific fluorescent substrate for plasmin.
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Fasudil dihydrochloride ≥98% (by TLC)
Supplier: ENZO LIFE SCIENCES
Inhibits Rho kinase (ROCK; Ki=0.33μM). Selective protein kinase A and G inhibitor (both Ki’s = 1.6μM). Inhibits agonist-induced activation of NADPH oxidase in human neutrophils (IC50=15μM). Inhibitor of myosin light chain kinase and Ca2+/calmodulin-dependent protein kinase II. Inhibits translocation of PKCβI, PKCβII and PKCζ. Cell permeable Ca2+ antagonist with antivasospastic properties.
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Tyrphostin B7 ≥99% (by TLC)
Supplier: ENZO LIFE SCIENCES
Member of the tyrphostin family of tyrosine kinase inhibitors. Selective inhibitor of the PDGF receptor kinase (IC50=20µM) vs. the EGF receptor kinase (IC50=820µM). Inhibits PDGF-induced mitogenesis in human bone marrow fibroblasts.
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AM 580 ≥98% (by TLC)
Supplier: ENZO LIFE SCIENCES
Retinoic acid analog which acts as a selective RARα agonist with no affinity for RXRs. Induces differentiation in leukemia cell lines and inhibits angiogenesis in chick embryos.
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Pifithrin-α hydrobromide ≥98% (by TLC)
Supplier: ENZO LIFE SCIENCES
Chemical inhibitor of p53 that protects mice from the side effects of cancer therapy. Reversibly blocks p53-dependent transcriptional activation and apoptosis. Protects against neuronal death in models of stroke and neurodegenerative disorders. Suppresses self-renewal of embryonic stem cells.
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BML-210 ≥98% (by TLC)
Supplier: ENZO LIFE SCIENCES
HDAC inhibitor developed at Enzo Life Sciences. Inhibits HDAC activity in HeLa nuclear extracts (IC50=5-10µM).
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6-Ketoprostaglandin-F1α ≥98% (by TLC)
Supplier: ENZO LIFE SCIENCES
Biosynthesis via hydrolysis of prostacyclin. A reliable parameter for measurement of prostacyclin. Ultra-pure.
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Gambogic acid ≥95% (by TLC)
Supplier: ENZO LIFE SCIENCES
Gambogic Acid is a natural product isolated from Garcinia Hurburyi. It induces apoptosis in several tumor cell lines including T47D breast cancer cells and MGC-803 human gastric carcinoma cells but not in normal cells. Apoptosis induction proceeds via upregulation of bax and inhibition of bcl-2 expression.The target of gambogic acid has been identified as the transferrin receptor.