Kifunensine ≥98% (by TLC)
Supplier: ENZO LIFE SCIENCES
Inhibits α-mannosidase. Inhibits asparagine-linked oligosaccharide processing. Immunomodulator.
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Bisindolylmaleimide I ≥98% (by TLC)
Supplier: ENZO LIFE SCIENCES
Potent and selective protein kinase C inhibitor which has been used effectively in platelets, Swiss 3T3 fibroblasts and macrophages. Inhibitory profile: PKC, IC50=0.02µM (inhibits α, ßI, ßII and γ subtypes with similar potency); PKA, IC50=2.0µM; phosphorylase kinase, IC50=0.7µM; insulin, EGF and PDGF receptor tyrosine kinases are not inhibited at concentrations up to 50µM.
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Monastrol ≥98% (by TLC)
Supplier: ENZO LIFE SCIENCES
Cell permeable non-tubulin-interacting mitosis inhibitor. Blocks mitosis (IC50=14µM) by binding to the mitotic kinesin Eg5.
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2',5'-Dideoxyadenosine ≥98% (by TLC)
Supplier: ENZO LIFE SCIENCES
Adenylate cyclase inhibitor
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4-Hydroxybenzylidenemalononitrile ≥98% (by TLC)
Supplier: ENZO LIFE SCIENCES
The tyrphostins are well known tyrosine kinase inhibitors. However, tyrphostin 8 has been shown to inhibit calcineurin (IC50=21 µM) while displaying weak inhibition of EGFR tyrosine kinase (IC50=560 µM).
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FH535 ≥98% (by TLC)
Supplier: ENZO LIFE SCIENCES
Inhibits the recruitment of the co-activators β-catenin and GRIP1
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Dorsomorphin ≥98% (by TLC)
Supplier: ENZO LIFE SCIENCES
Cell-permeable pyrrazolopyrimidine derivative that inhibits AMP kinase (Ki=109nM in the absence of AMP) in an ATP-competitive manner. It displays no significant inhibition of ZAPK, SYK, PKCT, PKA and JAK3. Decreases food intake in mice and inhibits the effects of AICAR and metformin. It has been shown to inhibit BMP type I receptors ALK2, ALK3 and ALK6. Promotes cardiomyogenesis in mouse embryonic stem cells. Induces protective autophagy in cancer cell lines.
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N-Arachidonoyldopamine ≥98% (by TLC)
Supplier: ENZO LIFE SCIENCES
Activator of CB1 receptor and TRPV1
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DICA ≥98% (by TLC)
Supplier: ENZO LIFE SCIENCES
Inhibitor of caspase-3 and caspase-7 binding to an allosteric site and not to the active site.
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(+/-)-Anatoxin ≥98% (by TLC)
Supplier: ENZO LIFE SCIENCES
Nicotinic acetylcholine receptor ligand.
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STAT3 Inhibitor V, Stattic ≥98% (by TLC)
Supplier: ENZO LIFE SCIENCES
Small molecule STAT3-specific inhibitor which blocks activation, dimerization and nuclear translocation via binding to the STAT3 SH2 domain. It is a very useful tool for exploring STAT3-mediated signaling pathways. It blocks LPS-mediated STAT3 tyrosine phosphorylation which leads to inhibition of LPS-mediated IL-1β and IL-6 production. In primary cultures of rat neural stem cells it blocks IL-15-induced differentiation.
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AUDA ≥98% (by TLC)
Supplier: ENZO LIFE SCIENCES
Novel inhibitor of soluble epoxide hydrolase (IC50=18nM and 69nM for the mouse and human enzymes respectively). Produces a hypotensive effect in angiotensin-infused rats and prevents and reverses cardiac hypertrophy in mouse models of cardiac hypertrophy.