1424 Results for: "TMC HALLCREST"
Palmityltrifluoromethylketone ≥98% (by TLC)
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Inhibitor of both Ca2+-dependent cytosolic cPLA2 (IC50=45 µM) and Ca2+-independent phospholipases A2 iPLA2 (IC50=3.8 µM).
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Chaetocin ≥98% (by TLC)
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Methyltransferase inhibitor
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N-Arachidonylglycine ≥98% (by TLC)
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FAAH inhibitor
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Midostaurin ≥98% (by TLC)
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Inhibitor of a variety of serine/threonine and tyrosine kinases, like protein kinase C (PKC), cyclic AMP-dependent protein kinase (PKA), S6 kinase, Akt (protein kinase B; PKB), epidermal growth factor receptor (EGFR) tyrosine kinase activity and others including KDR, VEGFR, PDGFR, c-kit and other receptor tyrosine kinases. Potently inhibits FLT-3 kinase including mutant forms found in acute myeloid leukemia in vitro and in vivo. Apoptosis inducer. Showed broad antiproliferative activity against various tumor cell lines. Selectively inhibits T lymphocyte production of TNF-α. Upregulates endothelial nitric oxide synthase (eNOS; NOS III). Abrogates tumor angiogenesis in vivo.
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U-75302 ≥98% (by TLC)
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Prostanoid receptor ligand.
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Baicalein ≥98% (by TLC)
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Lipoxygenase inhibitor
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Apigenin ≥97% (by TLC)
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Antioxidant and chemopreventive
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Latrunculin A ≥98% (by TLC)
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Ultra-pure; inhibits actin polymerization
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BMOV ≥96% (by TLC)
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Organic vanadium complex which acts as a potent insulin mimic.
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Anandamide ≥98% (by TLC)
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Endogenous [1] ligand for the CB1 receptor (CB1: Ki=52nm; CB2: Ki=1930nm [2]) and TRPV1 (Ki=5.78µM [3,4]). Inhibits NF-κB activation through direct binding to IKKβ [5] and induces apoptosis independently of cannabinoid or vanilloid receptors [6]. Activates the MAP kinase (MAPK/ERK) signalling pathway [7].
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Ilimaquinone ≥98% (by TLC)
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ADP-ribosylation factor inhibitor
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L-744,832 ≥98% (by TLC)
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Ras farnesyltransferase inhibitor. Induces tumor regression in transgenic mice with multiple oncogenic mutations by mediating alterations in both cell cycle control and apoptosis. Induces p21 expression and arrests cells at G1. Causes enhanced mitotic sensitivity to taxol.
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Palmitoylethanolamide ≥98% (by TLC)
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Endogenous cannabinoid. Weak ligand of CB1 (Ki=23.8µM) and CB2 (Ki=13.9µM) receptor. Inhibits fatty acid amide hydrolase (FAAH) (IC50=5.1µM). Immunosuppressant, anti-inflammatory, anti-nociceptive and anti-convulsant in vivo. The exact mode of action has not yet been revealed. It has been suggested that PEA: i) binds to a yet to be discovered cannabinoid receptor similar to CB2; ii) administered in vivo elicits the synthesis of endogenous agonists of CB2; iii) acts as an "entourage" compound by enhancing the activity and/or by influencing the turnover of endogenous agonists of CB2, possibly but not uniquely, by inhibiting their degradation.
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Calpeptin ≥98% (by TLC)
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Calpain and cathepsin inhibitor
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Virodhamine ≥98% (by TLC)
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Cannabinoid receptor ligand.
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Monastrol ≥98% (by TLC)
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Cell permeable non-tubulin-interacting mitosis inhibitor. Blocks mitosis (IC50=14µM) by binding to the mitotic kinesin Eg5.
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(S)-Mephenytoin ≥98% (by TLC)
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Cytochrome P450 substrate.
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2',5'-Dideoxyadenosine ≥98% (by TLC)
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Adenylate cyclase inhibitor
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Dorsomorphin ≥98% (by TLC)
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Cell-permeable pyrrazolopyrimidine derivative that inhibits AMP kinase (Ki=109nM in the absence of AMP) in an ATP-competitive manner. It displays no significant inhibition of ZAPK, SYK, PKCT, PKA and JAK3. Decreases food intake in mice and inhibits the effects of AICAR and metformin. It has been shown to inhibit BMP type I receptors ALK2, ALK3 and ALK6. Promotes cardiomyogenesis in mouse embryonic stem cells. Induces protective autophagy in cancer cell lines.
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Bisindolylmaleimide I ≥98% (by TLC)
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Potent and selective protein kinase C inhibitor which has been used effectively in platelets, Swiss 3T3 fibroblasts and macrophages. Inhibitory profile: PKC, IC50=0.02µM (inhibits α, ßI, ßII and γ subtypes with similar potency); PKA, IC50=2.0µM; phosphorylase kinase, IC50=0.7µM; insulin, EGF and PDGF receptor tyrosine kinases are not inhibited at concentrations up to 50µM.
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Kifunensine ≥98% (by TLC)
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Inhibits α-mannosidase. Inhibits asparagine-linked oligosaccharide processing. Immunomodulator.