58683 Results for: "Cayman Chemical"

Supplier: Cayman Chemical

BSA-Palmitate saturated fatty acid complex is composed of palmitic acid and bovine serum albumin (BSA) at an approximately 6:1 molar ratio of palmitate:BSA. It can be used for efficient fatty acid delivery to cells in culture for the purpose of monitoring fatty acid oxidation or similar processes in various cellular metabolic studies.

Supplier: Cayman Chemical

Hexadecanamide is a primary fatty acid amide that is derived from palmitic acid (C16:0) and belongs to a class of important cell signaling lipids.

Supplier: Cayman Chemical

ML RR-S2 CDA is a synthetic cyclic dinucleotide (CDN) that contains non-canonical 2'5'-phosphodiester bonds and is an activator of stimulator of interferon genes (STING).1 It contains mixed linkages (ML) with both 2'5' and 3'5' linkages, which leads to increased thermal stability of human STING in a differential scanning fluorimetry (DSF) assay. ML RR-S2 CDA increases type I interferon production by THP-1 human monocytes relative to unmodified cyclic di-AMP (CDA; Item No. 17753), indicating the ML enhances its action at human STING. It induces expression of IFN-β and the pro-inflammatory cytokines TNF-α, IL-6, and Mcp-1 in murine bone marrow macrophages (BMM) isolated from wild-type, but not STING-/-, mice. ML RR-S2 CDA also induces IFN-β expression in peripheral blood mononuclear cells (PBMCs) isolated from donors carrying STINGWT/WT, STINGWT/REF, and STINGWT/HAQ alleles. In vivo, ML RR-S2 CDA initiates tumor regression and prevents tumor growth upon tumor cell reimplantation in 4T1 breast and CT26 colon cancer mouse xenograft models.

Supplier: Cayman Chemical

Meropenem ≥98%

Supplier: Cayman Chemical

Cefoperazone is a cephalosporin antibiotic that is active in vitro against most Gram-positive and Gram-negative bacteria, including β-lactamase strains (3 – 4 µg/ml inhibits 90% of S. aureus growth). It has been studied in the treatment of upper and lower respiratory tract infections, urinary tract infections, gynecological infections, skin infections, as well as bacteremia.

Supplier: Cayman Chemical

Nitrocefin is a chromogenic cephalosporin substrate commonly used to detect β-lactamases in bacteria. The presence of β-lactamase activity is indicated by the appearance of a red color that is proportional in intensity to the original concentration of nitrocefin.

Supplier: Cayman Chemical

Ticagrelor ≥98%

Supplier: Cayman Chemical

BQCA is a highly selective positive allosteric modulator of the M₁ muscarinic acetylcholine receptor (mAChR), as it dose-dependently reduces the concentration of acetylcholine required to activate the M₁ receptor. The effective range for potentiation of M₁ in cells by BQCA is 0,1 to 100 μM with an inflection point value of 845 nM when 3 nM acetylcholine is used.

Supplier: Cayman Chemical

Taurolidine is a synthetic taurine analog with antimicrobial and anti-neoplastic actions. These displays broad bactericidal and fungicidal activity.

Supplier: Cayman Chemical

WYE-125132 is an ATP-competitive inhibitor of mTOR (IC₅₀ = 0,19 nM) that inhibits signaling through both mTORC1 and mTORC2. It is selective for mTOR over phosphatidylinositol 3-kinase isoforms. WYE-125132 is effective against mTORC1 and mTORC2 in diverse cancer models, both in vitro and in vivo. Oral administration of WYE-125132 alone blocks mTOR signaling and prevents tumor growth in breast, lung, renal, and glioma cancer xenografts in mice, while combination therapy with the VEGF-inhibitor bevacizumab causes complete regression of A498 renal carcinoma tumors. In addition to its applications in cancer, WYE-125132 has been used to delineate novel aspects of mTOR signaling.

Supplier: Cayman Chemical

β-D-Glucose ≥98%, crystalline solid

Supplier: Cayman Chemical

CID-2858522 ≥98%

Supplier: Cayman Chemical

Taurodeoxycholic acid is a taurine-conjugated form of the secondary bile acid deoxycholic acid. Taurodeoxycholic acid stimulates chloride ion secretion through calcium-activated chloride ion channels and cystic fibrosis transmembrane conductance regulator (CFTR) in Calu-3 airway epithelial cell monolayers when applied basolaterally. Serum levels of taurodeoxycholic acid increase approximately 5-fold in within two hours during an oral lipid tolerance test in humans.

Supplier: Cayman Chemical

Pilocarpine hydrochloride

Supplier: Cayman Chemical

2-Methylbenzamidoxime

Supplier: Cayman Chemical

Spermidine

Supplier: Cayman Chemical

G418 disulphate

Supplier: Cayman Chemical

7-dehydro Cholesterol (7-DHC) is an immediate precursor of cholesterol.

Supplier: Cayman Chemical

L-Sulforaphane is an isothiocyanate derived from the natural compound glucoraphanin, which is abundant in cruciferous vegetables, including broccoli. It has powerful antioxidant, anti-inflammatory, and anti-carcinogenic effects.

Supplier: Cayman Chemical

Phloretin

Supplier: Cayman Chemical

Anti-GPR120 Rabbit Polyclonal Antibody

Supplier: Cayman Chemical

Diallyl disulphide

Supplier: Cayman Chemical

Pyridine-2,4-dicarboxylic acid

Supplier: Cayman Chemical

Puromycin dihydrochloride

Supplier: Cayman Chemical

Lupeol, a dietary triterpene found in certain fruits, vegetables, and medicinal plants, has potent anti-inflammatory, anticarcinogenic, antimutagenic, and antimalarial activity. It suppresses the growth of hepatocellular carcinoma cell lines SMMC7721 and HepG2 with IC50 values of 45 and 48.5 μM and melanoma cell lines Mel 928 and Mel 1241 with IC50 values of 75 and 72 μM.¹'² At 0.76 g/kg lupeol causes a significant decrease in the blood pressure of stroke-prone hypertensive rats and reduces expression of hepatic genes involved in triglyceride and cholesterol synthesis.³ It also has significant anti-inflammatory effects at 50 mg/kg in a carrageenan-induced edema model, inhibiting neutrophil migration.⁴

1. Tarapore, R.S.,Siddiqui, I.A.,Saleem, M., et al. Specific targeting of Wnt/β-catenin signaling in human melanoma cells by a dietary triterpene lupeol. Carcinogenesis 31(10), 1844-1853 (2010).
2. He, Y.,Liu, F.,Zhang, L., et al. Growth inhibition and apoptosis induced by lupeol, a dietary triterpene, in human hepatocellular carcinoma cells. Bio.Pharm.Bull. 34(4), 517-522 (2011).
3. Ardiansyah,Yamaguchi, E.,Shirakawa, H., et al. Lupeol supplementation improves blood pressure and lipid metabolism parameters in stroke-prone spontaneously hypertensive rats. Bioscience, Biotechnology, and Biochemistry 76(1), 183-185 (2012).
4. Lucetti, D.L.,Lucetti, E.C.,Bandeira, M.A., et al. Anti-inflammatory effects and possible mechanism of action of lupeol acetate isolated from Himatanthus drasticus (Mart.) Plumel. Journal of Inflammation 7(60), 1-11 (2010).

Supplier: Cayman Chemical

6-Propyl-2-thiouracil

Supplier: Cayman Chemical

Fmoc-Osu (N-(9-fluorenylmethoxycarbonyloxy)succinimide)

Supplier: Cayman Chemical

Pyronin G

Supplier: Cayman Chemical

Ginkgolide B

Supplier: Cayman Chemical

Anti-Trx1 Mouse Monoclonal Antibody [clone: 2G11]