162364 Results for: "3,4-Di(1H-indol-3-yl)-1H-pyrrole-2,5-dione"

Supplier: TCI

D-(+)-Camphor ≥98.0% (by GC)

Supplier: Thermo Fisher Scientific

D-(+)-Camphor ≥98%

Supplier: TRANE TECHNOLOGIES

Purpose-built for life science applications, FARRAR®’s ULC series including the Ultra-Low Chamber (ULC-190), Ultra-Low Chamber (ULC-328), and the new Ultra-Low Chamber (ULC-259) are the only −20 to −80 °C, forced-air, ultra-low-temperature freezers on the market with air and water-cooled options.

Supplier: Brand

PP. Eight connected 0,2 or 0,15 ml PCR tubes with attached flat individual caps. The tubes are held together by three connectors for increased rigidity.

Supplier: Merck

L(+)-Cysteine hydrochloride monohydrate, Millipore®

Supplier: STEMCELL Technologies

Stromal cell-derived factor 1 alpha (SDF-1α) is a member of the CXC group of chemokines that binds to the G-protein coupled receptor, CXCR4, to regulate migration, proliferation, differentiation, and survival of many cell types including hematopoietic stem cells, B cells, and T cells. It is produced by bone marrow stromal cells, osteoblasts, endothelial cells, and neuronal cells. SDF-1α was first identified as the pre-B-cell growth-stimulating factor (PBSF) in the mouse bone marrow-derived stromal cell line, PA6, in the growth of B cell precursors (Hayashi et al.). SDF-1α primarily regulates cell motility during development and adulthood, including the homing of hematopoietic stem cells and neutrophils to fetal bone marrow during ontogeny (Ara et al. 2003a) and the recruitment of endothelial progenitor cells from bone marrow during angiogenesis in adulthood (Zheng et al.). In addition to its role in hematopoiesis, the SDF-1α/CXCR4 signaling pathway is also essential for the homing of primordial germ cells to gonads (Ara et al. 2003b), the migration of granule cells in the cerebellum during neurogenesis (Zou et al.), and the migration of breast cancer cells to sites of metastasis (Muller et al.).

Supplier: STEMCELL Technologies

Interleukin 17A (IL-17A) is the founding member of the family of cytokines that includes Interleukin 17B through Interleukin 17F. It is a potent proinflammatory cytokine that plays a key role in defense against pathogens. IL-17A and IL-17F signal as homodimers or heterodimers through the same receptor, and activate NF-kB, MAPK, and C/EBP pathways (Gaffen). IL-17A receptor is expressed on a variety of cell types, including hematopoietic cell compartments. IL-17A is produced by T helper 17 cells, CD8+ T cells, γδ T cells, natural killer T cells, B cells, neutrophils, innate lymphoid cells and mesenchymal stromal cells (MSCs; Zenobia and amp; Hajishengallis; Mojsilovic et al.). IL-17A receptor is expressed at particularly high levels on stromal cells, including MSCs. IL-17A increases the frequency and the average size of colony-forming units-fibroblast derived from bone marrow, as well as the proliferation of bone marrow-derived MSCs. IL-17A suppresses osteogenic differentiation and bone formation of bone marrow-derived MSCs. The action of IL-17A on hematopoiesis is deeply reliant on the microenvironment and the induction of other regulators. In healthy mouse bone marrow, IL-17A stimulates myeloid and early stage erythroid progenitor cells but inhibits late stage erythroid progenitor cells (Mojsilovic et al.).

Supplier: STEMCELL Technologies

R-Spondin-1 (RSPO1) is the prototype member of the R-Spondin (RSPO) protein subfamily of a superfamily of thrombospondin type 1 repeat (TSR-1)-containing proteins (Chen et al.; Kamata et al.; Kazanskaya et al.; Kim et al.). Although unable to initialize signaling, RSPO family members are potent enhancers of WNT signaling (Cruciat and Niehrs; de Lau et al.; Kamata et al.; Kazanskaya et al.). They are characterized by a TSR-1 domain, a carboxy-terminal region with positively charged amino acids, and two N-terminal furin-like cysteine-rich repeats (Glinka et al.; Kazanskaya et al.). R­-Spondin-1 activates β­-catenin signaling via the WNT signaling cascade and by indirectly increasing low-density lipoprotein receptor-related protein 6 (LRP6) on the cell surface. It does this by binding leucine-rich repeat-containing G-protein-coupled receptor 5 (LGR5), and competing with WNT antagonist DKK­1 for binding to the WNT co­receptors, Kremen and LRP­6, which reduces DKK­1-­mediated internalization of LRP6 (Binnerts et al.). RSPO1 is involved in a wide range of pleiotropic roles during embryogenesis, it is required for the specification of hematopoietic stem cells, and it has been shown to be important in the growth, survival, and migration of ovarian cancer cells (Cruciat and Niehrs; de Lau et al.; Genthe and Clements; Liu et al.).

Supplier: Thermo Fisher Scientific

L(+)-Cysteine hydrochloride monohydrate ≥99%

Supplier: Thermo Fisher Scientific

L(+)-Potassium sodium tartrate tetrahydrate 99.0-102.0% ACS

Supplier: TCI

L(+)-Potassium sodium tartrate tetrahydrate ≥98.0% (by titrimetric analysis)

Supplier: STEMCELL Technologies

Interleukin-8 (IL-8) is a member of the CXC subfamily of chemokines and is produced by leukocytic cells (monocytes, T cells, neutrophils, and natural killer cells) and non-leukocytic somatic cells (endothelial cells, fibroblasts, and epithelial cells), with the most prominent source being monocytes and macrophages. Its production is induced by inflammatory stimuli, such as IL-1. IL-8, also known as CXCL8, activates neutrophils inducing chemotaxis, exocytosis, and the respiratory burst (Baggiolini and Clark-Lewis; Mukaida). IL-8 is considered one of the most potent neutrophil chemoattractants in inflammation and binds to two different chemokine receptors on leukocytes: the G protein-coupled receptors CXCR1 and CXCR2 (Hoffmann et al.; de Oliveira et al.). IL-8 has angiogenic effects on human intestinal microvascular endothelial cells in vitro that are mediated by CXCR2 (Heidemann et al.). IL-8 is reported to promote breast cancer progression by increasing cell invasion, angiogenesis, and metastasis and has been reported to be involved in regulating breast cancer stem-like cells (Singh et al.). IL-8 also has proangiogenic properties in inflammatory diseases of the conjunctiva, cornea, iris, retina, and orbit (Ghasemi et al.). It was also shown that a major T cell effector function in human newborns is IL-8 production, which has the potential to activate antimicrobial neutrophils and gamma/delta T cells (Gibbons et al.). A variety of human pathogens, such as HIV and Mycobacterium tuberculosis, have been shown to induce IL-8 production by monocytes and macrophages (Friedland et al.; Meddows-Taylor et al.).

Supplier: TCI

L(+)-Cysteine hydrochloride monohydrate ≥99.0% (by titrimetric analysis)

Supplier: Merck

L(+)-Histidine monohydrochloride monohydrate, Millipore®

Supplier: Thermo Fisher Scientific

L(+)-Potassium sodium tartrate tetrahydrate 99+% for analysis

Supplier: Merck

L(+)-Histidine monohydrochloride monohydrate for synthesis, Sigma-Aldrich®

Supplier: Spectrum Chemical

Form: Powder

Supplier: Thermo Fisher Scientific

Antimony(III) potassium oxitartrate trihydrate 99+%

Supplier: TCI

L(+)-Histidine monohydrochloride monohydrate ≥98.0% (by HPLC, titration analysis)

Supplier: Thermo Fisher Scientific

Antimony(III) potassium oxitartrate trihydrate 99.0-103.0% ACS

Supplier: Thermo Fisher Scientific

L(+)-Histidine monohydrochloride monohydrate 98%

Supplier: Thermo Fisher Scientific

L(+)-Cysteine hydrochloride monohydrate 98.5-101.5% (dry basis)

Supplier: MERCK PRODUCTION CHEMICALS

Calcium lactate pentahydrate, soluble, EMPROVE® ESSENTIAL E327, FCC, BP, Ph. Eur., JP, USP, extra pure suitable for use as excipient, SAFC®

Supplier: MP Biomedicals

Cysteine is a major biological source of sulphur and is one of the two common sulphur-containing amino acids. It is a NMDA glutamatergic receptor antagonist.

Supplier: Spectrum Chemical

Calcium Lactate, Pentahydrate, USP, FCC, EP is a filler/diluent excipient.

Supplier: Honeywell Chemicals

L(+)-Potassium sodium tartrate tetrahydrate ≥99.5% (by perchloric acid titration), Puriss. p.a.

Supplier: Thermo Fisher Scientific

L(+)-Potassium sodium tartrate tetrahydrate ACS

Supplier: MP Biomedicals

L-Histidine has been used to study cultures of the human T-lymphoblastic leukemia cell line MOLT-4 to study modulation of apoptosis. Exogenous histidine has been shown to enhance the biosynthesis of lovastatin by cultured Aspergillus terreus. Histidine has been utilised as a single nitrogen source to probe swarming in Pseudomonas aeruginosa on agar. An in vivo study has used L-histidine to diminish the net secretory response of the small intestine of of cholera toxin-challenged mice.

Supplier: Thermo Fisher Scientific

Sodium-L(+)-glutamate monohydrate 99%

Supplier: TCI

Sodium-L(+)-glutamate monohydrate ≥99.0% (by titrimetric analysis)