IL-10 is an anti-inflammatory cytokine produced by macrophages and type 2 T helper (Th2) cells.
- High quality
- Low endotoxin
- Lot-to-lot consistency
- Animal free
- Manufactured following GMP guidelines
Inhibits the production of pro-inflammatory cytokines such as interferon gamma (IFNγ), tumor necrosis factor alpha (TNFα), interleukin 2 (IL-2), interleukin 3 (IL-3), interleukin 4 (IL-4), and granulocyte-macrophage colony-stimulating factor (GM-CSF), made by macrophages and regulatory T cells
Suppresses antigen presentation on antigen presenting cells, and enhances the survival, proliferation, and antibody production of B cells
The biological activity of CTGrade GMP interleukins and growth factors is standardised, where applicable, to WHO International standards, providing cell and gene therapy developers consistent, lot-to-lot biological activity and performance
Host Cell Protein: ≤30 ng/ml
Host Cell DNA: ≤0,01 ng/ml
Sterility testing: No Growth
Mycoplasma: Negative
- Conjugation:Unconjugated
- Protein function:Cytokine
- Protein/peptide type:Recombinant
- Source:E. coli
- Species:Human
- Storage conditions:At or below –20 °C
- Endotoxin content:Endotoxin LAL (EU/µg) ≤0,05
- Biological activity:Bioactivity Assay: Proliferation of MC/9, ED₅₀ ≤5 ng/ml, Bioactivity ≥5,0×10³ IU/µg
- Gene ID:P22301
- Reconstitution instructions:Sterile water at 0,1 - 0,5 mg/ml
- Endotoxin-free:N
- Carrier-free:Y
- Protease-free:N
- Animal-free:Y
- Protein synonyms:B-TCGF|TGIF|CSIF
- Protein/peptide name:CTGrade GMP IL-10
- Purity:≥97%
- Molecular weight:18,8 kDa
- Sequence:MSPGQGTQSE NSCTHFPGNL PNMLRDLRDA FSRVKTFFQM KDQLDNLLLK ESLLEDFKGY LGCQALSEMI QFYLEEVMPQ AENQDPDIKA HVNSLGENLK TLRLRLRRCH RFLPCENKSK AVEQVKNAFN KLQEKGIYKA MSEFDIFINY IEAYMTMKIR N
- Endotoxin level:Low
- Formulation:10 mM Sodium phosphate, pH 7,5
- Nuclease-free:N
- Grade:GMP
- Shipping temperature:Ambient
- Tested applications:Bioassay