Specifications
- Antibody type:Primary
- Antigen name:Lymphocyte Antigen 6 Complex Locus G
- Antigen symbol:LY6G
- Clone:1A8
- Flow cytometry:Yes
- Host:Rat
- ImmunoChemistry:Yes
- ImmunoPrecipitation:Yes
- Isotype:IgG2a
- Reactivity:Mouse
- Neutralisation:Yes
- Gene ID:546644
- Antigen synonyms:Gr1|Gr-1|Ly-6G
- Storage temperature:Store undiluted at 2-8 °C, protect from light, do not freeze.
- Tested applications:Functional Assay
- Pk:100 µG
Specifications
About this item
The 1A8 antibody binds to mouse Ly-6G, commonly known as Gr-1, a member of the Ly-6 superfamily of GPI-anchored cell surface proteins with roles in cell signaling and cell adhesion. Gr-1 is differentially expressed during development and maturation of cells in the myeloid lineage and is expression at varying stages and levels on monocytes, macrophages, granulocytes, and peripheral neutrophils.
In the mouse, the 1A8 antibody is typically used in combination with the macrophage labeling antibody M1/70 (Anti-CD11b) for phenotypic analysis of monocytes, macrophages and granulocytes. Note: for identification of Ly-C, an alternative antibody, clone RB6-8C5, has been reported to cross-react with Ly-6C on cells expressing this antigen (Fleming et al. 1993. J. Immunol. 151:2399-2408 and Sasmono et al. 2007. J. Leukoc. Biol. 82: 111-123) and has been cited in the literature for identification of Ly-6G/Ly-6C.
Type: Primary
Antigen: LY6G
Clonality:
Clone: 1A8
Conjugation:
Epitope:
Host: Rat
Isotype: IgG2a
Reactivity: Mouse