Specifications
- Antibody type:Primary
- Antigen name:Tumor Necrosis Factor Receptor Superfamily Member 18
- Antigen symbol:TNFRSF18
- Clone:DTA-1
- Flow cytometry:Yes
- Host:Rat
- Isotype:IgG2b
- Reactivity:Mouse
- Neutralisation:Yes
- Gene ID:21936
- Antigen synonyms:CD357|TNFRSF18|Activation-inducible TNFR Family Receptor|Glucocorticoid-induced TNFR-related Protein|AITR|Tumor Necrosis Factor Receptor Superfamily Member 18
- Storage temperature:Store undiluted at 2...8 °C, protect from light, do not freeze.
- Tested applications:Functional Assay
- Size:500 µg
- Pk:500 µG
Specifications
About this item
The DTA-1 antibody reacts with mouse CD357, also known as GITR or AITR (in humans), a 66-70 kDa member of the Tumor Necrosis Factor superfamily (TNFRSF18). GITR is primarily found on T cells, and its function may vary depending on the T cell type where it is expressed. GITR is upregulated on activated T cells where it provides co-stimulation, yet GITR may promote the inhibition of CD4+ CD25+ Treg cells, where it is expressed at high levels. GITR ligand (GITRL) is found on B cells, macrophages, dendritic and endothelial cells, and is implicated in regulating both innate and adaptive immune responses.
The DTA-1 antibody may be used for analysis of GITR expression on T cells, and is also commonly used in vitro as an agonistic antibody to induce GITR signaling in various assays.