Human Recombinant IL-4 (from E. coli)

About this item

Interleukin 4 (IL-4) is an immunomodulatory cytokine that functions to induce naïve helper T cells to differentiate into type 2 T helper (Th2) cells. Th2 cells subsequently produce more IL-4 in a positive feedback loop. IL-4 also promotes immunoglobulin IgG to IgE isotype switching on B cells. IL-4 binds the IL-4Rα receptor to activate STAT6 signaling.

High quality
Low endotoxin
Affordable

Caution: This product is for research use only and is not for use in humans.

Specifications

Conjugation:
Unconjugated
Protein function:
Cytokine
Protein/peptide type:
Recombinant
Source:
E. coli
Species:
Human
Storage conditions:
–20 °C
Endotoxin content:
Endotoxin LAL (EU/µg) ≤0,1
Biological activity:
Bioactivity Assay: TF-1 cell proliferation, ED₅₀ ≤0,25 ng/ml, Bioactivity ≥4,0×10⁶ units/mg
Gene ID:
P05112
Reconstitution instructions:
Sterile water at 0,1 mg/ml
Endotoxin-free:
N
Carrier-free:
Y
Protease-free:
N
Animal-free:
Y
Protein synonyms:
BCGF|B-cell stimulatory factor-1|BCDF|BSF-1
Protein/peptide name:
IL-4 (AF)
Purity:
≥95%
Molecular weight:
15,1 kDa
Sequence:
MHKCDITLQE IIKTLNSLTE QKTLCTELTV TDIFAASKNT TEKETFCRAA TVLRQFYSHH EKDTRCLGAT AQQFHRHKQL IRFLKRLDRN LWGLAGLNSC PVKEANQSTL ENFLERLKTI MREKYSKCSS
Endotoxin level:
Low
Formulation:
0,1% Trifluoroacetic acid (TFA)
Nuclease-free:
N
Grade:
RUO
Shipping temperature:
RT
Tested applications:
Bioassay