CaM kinase inhibitor

AIP (autocamtide-2-related inhibitory peptide) is a highly specific and potent inhibitor of CaM kinase II. This peptide is derived from the CaM kinase II substrate autocamtide-2 (BML-P101) but alanine is substituted for threonine at the 9-position. AIP at 1 µM completely inhibited CaM kinase II but did not affect PKC, PKA, CaMKIV and other brain extract kinases. A cell-permeable, myristoylated version is available (BML-P212).