- Pk:20 µG
- Protein/peptide type:Recombinant
- Source:HEK293 cells
- Species:Human
- Biological activity:The bio-activity was determined by dose-dependent stimulation of the proliferation of mouse B9 hybridoma cells. The ED50 < 0. 05 ng/mL, corresponding to a specific activity of >2X107 Unit/mg. Measured by its binding ability in a functional ELISA. Immobilized Human IL-6 /Interleukin-6 Protein,HEK293 expressed at 5μg/mL (100 μL/well),can bind Recombinant Human IL6R /CD126 Protein. The EC50 is typically 0. 05-0. 4μg/mL.
- Protein synonyms:Interleukin-6|HSF|HGF|IFNB2|IL6|BSF2
- Protein/peptide name:Interleukin 6
- Purity:>98% as determined by SDS-PAGE.
- Molecular weight:20.8 kDa
- Formulation:Lyophilized, PBS, pH7.4
- Tested applications:Western Blot
Interleukin 6 (IL-6) is also known as HGF, BSF2,HSF, IFNB2 and IL-6, originally identified as a B cell differentiation factor, is a multifunctional cytokine that regulates immune responses, hematopoiesis, acute phase responses, and inflammatory reactions.It is secreted by T cells, macrophages , monocytes, fibroblasts,endothelial cells,et.al. to stimulate immune response to trauma, especially burns or other tissue damage leading to inflammation. Interleukin 6 has been shown to interact with interleukin-6 receptor and glycoprotein. IL-6 is relevant to many disease processes such as diabetes,atherosclerosis, depression,Alzheimer's Disease,systemic,lupus erythematosus,prostate cancer and rheumatoid arthritis. Advanced/metastatic cancer patients have higher levels of IL-6 in their blood.Hence there is an interest in developing anti-IL-6 agents as therapy against many of these diseases.