Anti-IFIH1 Mouse Monoclonal Antibody [clone: Hely-1]
Catalog # PRSI36-114
Supplier: ProSci Inc.
Specifications
- Antibody type:Primary
- Antigen name:interferon induced with helicase C domain 1
- Antigen symbol:IFIH1
- Clonality:Monoclonal
- Clone:Hely-1
- Conjugation:Unconjugated
- ELISA:Yes
- Host:Mouse
- ImmunoPrecipitation:Yes
- Isotype:IgG1
- Reactivity:Human
- Western blot:Yes
- Form:Liquid
- Gene ID:64135
- Antigen synonyms:Helicard|Melanoma Differentiation-associated Gene 5
- Storage buffer:In PBS containing 10% glycerol and 0.02% sodium azide.
- Storage temperature:Stable for at least 1 year after receipt when stored at -20˚C.
- Concentration:1 mg/ml
- Shipping temperature:-20°C
- Immunogen:Recombinant human MDA5 (aa 78-555).
- Purification:>95% (SDS-PAGE)
- Size:100 μg
- Pk:100 µG
Specifications
About this item
RIG-I and MDA5 are highly conserved helicases involved in the innate immune response to virus. RIG-I is a member of the DEAD-box RNA helicases and is activated by cytoplasmic dsRNA and 5’-ppp RNA produced during the viral replication. The protein is characterized by a N-terminal region with two caspase recruitment domains (CARD) and a C-terminal region harboring potential ATP-dependent RNA helicase activity. RIG-1 recruits the CARD adaptor inducing IFN-beta (Cardif) in a CARD-CARD-dependent manner resulting in NF-kappaB and IRF3 activation.
Type: Primary
Antigen: IFIH1
Clonality: Monoclonal
Clone: Hely-1
Conjugation: Unconjugated
Epitope:
Host: Mouse
Isotype: IgG1
Reactivity: Human