Specifications
- Antibody type:Primary
- Antigen name:Mitogen-Activated Protein Kinase 8 Interacting Protein 1
- Antigen symbol:MAPK8IP1
- Clonality:Polyclonal
- Conjugation:Cy5®
- Host:Rabbit
- ImmunoChemistry:Yes
- Isotype:IgG
- Reactivity:Human,Rat,Mouse
- Cross adsorption:No
- Form:liquid
- Gene ID:9479
- Antigen synonyms:islet-brain 1|JNK-interacting protein 1|IB1|IB-1|JIP1|C-Jun-amino-terminal kinase-interacting protein 1|JNK MAP kinase scaffold protein 1|JIP-1|PRKM8 interacting protein|PRKM8IP
- Storage buffer:Aqueous buffered solution containing 100ug/ml BSA, 50% glycerol and 0.09% sodium azide. Store at 4°C for 12 months.
- Storage temperature:Store at 4°C for 12 months
- Concentration:1 μg/μl
- Shipping temperature:4°C
- Immunogen:435-485/711
- Purification:Purified by Protein A
- Pk:100 µl
Specifications
About this item
The JNK-interacting protein (JIP) group of scaffold proteins selectively mediates JNK signaling by aggregating specific components of the MAPK cascade to form a functional JNK signaling module. Required for JNK activation in response to excitotoxic stress. Cytoplasmic MAPK8IP1 causes inhibition of JNK-regulated activity by retaining JNK in the cytoplasm and inhibiting JNK phosphorylation of c-Jun. May also participate in ApoER2-specific reelin signaling. Directly, or indirectly, regulates GLUT2 gene expression and beta-cell function. Appears to have a role in cell signaling in mature and developing nerve terminals. May function as a regulator of vesicle transport, through interactions with the JNK-signaling components and motor proteins (By similarity). Functions as an anti-apoptotic protein and whose level seems to influence the beta-cell death or survival response.
Recommended Dilutions: IF(IHC-P): 1:50-200
Type: Primary
Antigen: MAPK8IP1
Clonality: Polyclonal
Clone:
Conjugation: Cy5®
Epitope:
Host: Rabbit
Isotype: IgG
Reactivity: Human, Mouse, Rat