- Pk:96
- Primary antibody reactivity:Human
- Description:Human TNFRSF13B ELISA Kit
- Detection range:93,8 - 6000 pg/ml
- Sensitivity:<10 pg/ml
Human TNFRSF13B ELISA Kit for the quantitative detection of human tumour necrosis factor receptor superfamily member 13B (TNFRSF13B, TACI) in cell culture supernates, serum and plasma (heparin, EDTA).
TNFRSF13B is a transmembrane receptor protein found predominantly on the surface of B cells, which are an important part of the immune system. TACI controls T cell-independent B cell antibody responses, isotype switching, and B cell homeostasis. TACI is a lymphocyte-specific member of the tumor necrosis factor (TNF) receptor superfamily. It was originally discovered because of its ability to interact with calcium-modulator and cyclophilin ligand (CAML). TACI was later found to play a crucial role in humoral immunity by interacting with two members of the TNF family: BAFF and APRIL. These proteins signal through TACI inducing activation of several transcription factors including NFAT, AP-1, and NF-kappa-B which then modulate cellular activities. Defects in the function of TACI can lead to immune system diseases.