Specifications
- Pk:96
- Primary antibody reactivity:Human
- Description:Human TNFRSF13B ELISA Kit
- Detection range:93,8 - 6000 pg/ml
- Sensitivity:<10 pg/ml
Specifications
About this item
Human TNFRSF13B ELISA Kit for the quantitative detection of human tumour necrosis factor receptor superfamily member 13B (TNFRSF13B, TACI) in cell culture supernates, serum and plasma (heparin, EDTA).
TNFRSF13B is a transmembrane receptor protein found predominantly on the surface of B cells, which are an important part of the immune system. TACI controls T cell-independent B cell antibody responses, isotype switching, and B cell homeostasis. TACI is a lymphocyte-specific member of the tumor necrosis factor (TNF) receptor superfamily. It was originally discovered because of its ability to interact with calcium-modulator and cyclophilin ligand (CAML). TACI was later found to play a crucial role in humoral immunity by interacting with two members of the TNF family: BAFF and APRIL. These proteins signal through TACI inducing activation of several transcription factors including NFAT, AP-1, and NF-kappa-B which then modulate cellular activities. Defects in the function of TACI can lead to immune system diseases.