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Cerulenin ≥98% (by TLC)

Supplier: ENZO LIFE SCIENCES

Fatty acid synthase inhibitor

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Cerulenin ≥98%, crystalline solid

Supplier: Cayman Chemical

A number of tumor cells and cell lines have been observed to have highly upregulated expression and activity of fatty acid synthase (FAS). Inhibition of FAS by the irreversible inhibitor cerulenin leads to cytotoxicity and apoptosis in human cancer cell lines, an effect believed to be mediated by the accumulation of malonyl-coenzyme A in cells with an upregulated FAS pathway. Cerulenin also leads to profound weight loss and feeding inhibition in both high-fat diet wild type obese and leptin-deficient ob/ob mice.

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