- Antibody type:Primary
- Antigen name:c-Jun Thr239
- Clonality:Polyclonal
- Conjugation:Alexa Fluor® 750
- Flow cytometry:Yes
- Host:Rabbit
- Isotype:IgG
- Reactivity:Human
- Western blot:Yes
- Form:Liquid
- Gene ID:3725
- Antigen synonyms:JUNC|c-Jun phospho T239|AP-1|Transcription factor AP-1|Proto oncogene cJun|Activator Protein 1|Activator 1|JUN_HUMAN|V-jun avian sarcoma virus 17 oncogene homolog|vJun Avian Sarcoma Virus 17 Oncogene Homolog|Jun oncogene|p-c-Jun phospho T239|JUN|AP1|Proto-oncogene c-Jun|JUN protein|p39|Enhancer Binding Protein AP1|Jun Activation Domain Binding Protein|c-Jun Thr239|Transcription Factor AP1|AP 1|V jun avian sarcoma virus 17 oncogene homolog
- Modification:Phosphorylation (Thr239)
- Storage buffer:Aqueous buffered solution containing 0,01 M TBS (pH 7,4) with 1% BSA, 0,03% Proclin300 and 50% Glycerol
- Molecular weight:43 kDa
- Storage temperature:Store at −20 °C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
- Concentration:1 µg/µl
- Shipping temperature:4 °C
- Immunogen:KLH conjugated synthetic phosphopeptide derived from human c-Jun around the phosphorylation site of Thr239
- Purification:Purified by Protein A
- Pack type:Vial
- Pk:100 µl
The human protooncogene JUN is the putative transforming gene of avian sarcoma virus 17, and it encodes a protein which is highly homologous to the viral protein. cJun (previously known as the Fos binding protein p39) and c Fos form a complex in the nucleus. AP 1 (activating protein 1) is a collective term referring to these dimeric transcription factors composed of Jun, Fos or ATF subunits that bind to a common DNA site, the AP1 binding site. AP 1 proteins, mostly the Jun group, regulate the expression and function of cell cycle regulators such as Cyclin D1, p53, p21 (cip1/waf1), p19 (ARF) and p16. Fos and Jun proto oncogene expression is induced transiently by a variety of extracellular stimuli associated with mitogenesis, differentiation processes or depolarisation of neurons. JUN has been mapped to 1p32 to p31, a chromosomal region involved in both translocations and deletions in human malignancies.
Type: Primary
Antigen: c-Jun Thr239
Clonality: Polyclonal
Clone:
Conjugation: ALEXA FLUOR® 750
Public Immunogen Range:
Host: Rabbit
Isotype: IgG
Reactivity: Human