Specifications
- Antistofftype:Primary
- Antigen-navn:SKI protein
- Antigensymbol:SKI
- Klonalitet:Polyclonal
- Konjugering:Cy3®
- Vert:Rabbit
- ImmunoKjemi:Yes
- Isotype:IgG
- Reaktivitet:Human,Rat,Mouse
- Kyssabsorpsjon:No
- Skjema:liquid
- Gen-ID:6497
- Antigen synonymer:Ski oncogene|Proto-oncogene c-Ski|SGS|Ski|SKV
- Lagringsbuffer:Aqueous buffered solution containing 100ug/ml BSA, 50% glycerol and 0.09% sodium azide. Store at 4°C for 12 months.
- Lagringstemp:Store at 4°C for 12 months
- Konsentrasjon:1 μg/μl
- Frakttemp.:4°C
- Rensing:Purified by Protein A
- Fp:100 µl
Specifications
About this item
SKI is a nuclear protein that forms homodimers and heterodimers and binds to DNA to function as transcriptional activators and repressors. The SKI oncoprotein dramatically affects cell growth, differentiation, and/or survival. SKI was shown to act in distinct signaling pathways including those involving nuclear receptors, transforming growth factor beta, and tumor suppressors. SKI inhibits transforming growth factor-beta (TGF-beta) signaling through interaction with Smad proteins. SKI represses Smad-mediated transcriptional activation, probably through its action as a transcriptional co-repressor. SKI also inhibits TGF-beta-induced downregulation of genes such as c-myc.
Recommended Dilutions: IF(IHC-P): 1:50-200
Type: Primary
Antigen: SKI
Clonality: Polyclonal
Clone:
Conjugation: Cy3®
Epitope:
Host: Rabbit
Isotype: IgG
Reactivity: Human, Mouse, Rat