Specifications
- Antibody type:Primary
- Antigen name:UBE3A/E6-AP
- Clonality:Polyclonal
- Conjugation:Alexa Fluor® 750
- Host:Rabbit
- ImmunoChemistry:Yes
- ImmunoFluorescence:Yes
- Isotype:IgG
- Reactivity:Human
- Epitope:701-800/875
- Form:Liquid
- Gene ID:7337
- Antigen synonyms:Human papillomavirus E6-associated protein|E6AP ubiquitin protein ligase|NY REN 54 antigen|UBE 3A|Oncogenic protein associated protein E6 AP|Human papilloma virus E6 associated protein|Ubiquitin protein ligase E3A|Ubiquitin-protein ligase E3A|UBE3A protein|UBE3A_HUMAN|ANCR|Ube3a|E6 AP|Angelman syndrome|EPVE6AP|AS|Human papilloma virus E6 associated protein Angelman syndrome|Oncogenic protein-associated protein E6-AP|Renal carcinoma antigen NY-REN-54|CTCL tumor antigen se37 2|E6AP ubiquitin-protein ligase|HPVE6A|Renal carcinoma antigen NY REN 54|E6AP antibody E6AP ubiquitin protein ligase|Oncogenic protein associated protein E6AP
- Modification:Unmodified
- Storage buffer:Aqueous buffered solution containing 0,01 M TBS (pH 7,4) with 1% BSA, 0,03% Proclin300 and 50% Glycerol
- Molecular weight:105 kDa
- Storage temperature:Store at −20 °C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
- Concentration:1 µg/µl
- Shipping temperature:4 °C
- Immunogen:KLH conjugated synthetic peptide derived from human UBE3A/E6-AP
- Tested applications:ICC
- Purification:Purified by Protein A
- Pack type:Vial
- Pk:100 µl
Specifications
About this item
E6-associating protein is a component of the ubiquitin-mediated proteolytic pathway, which selectively targets proteins for degradation by the 26S proteasome. Ubiquitin (Ub) is directly conjugated to protein substrates by the transfer of Ub from an E2 ubiquitin conjugating enzyme to the target protein. This conjugation is facilitated by the enzymatic activity of E3 ubiquitin ligase family members such as E6-AP. Several substrates of E6-AP have been identified and include the tumour suppressor protein p53 and the mammalian homolog of Rad23, HHR23A. Previous studies have indicated that E6-AP associates with the human papillomavirus E6 oncogene, which complexes with p53 and thereby potentiates E6-AP mediated ubiquitination of p53. Genetic mutations that impair E6-AP activity result in the accumulation of p53 in the cytoplasm, and, in many instances, these mutations are associated with the development of the rare neurodevelopmental disorder Angelman syndrome (AS), which is characterised by severe motor dysfunction and mental retardation.
Type: Primary
Antigen: UBE3A/E6-AP
Clonality: Polyclonal
Clone:
Conjugation: ALEXA FLUOR® 750
Public Immunogen Range: 701-800/875
Host: Rabbit
Isotype: IgG
Reactivity: Human