- Antibody type:Primary
- Antigen name:Activin receptor interacting protein 1
- Antigen symbol:AIP1
- Clonality:Polyclonal
- Conjugation:FITC (Fluorescein Isothiocyanate)
- Host:Rabbit
- ImmunoChemistry:Yes
- Isotype:IgG
- Reactivity:Human,Rat,Mouse
- Cross adsorption:No
- Form:liquid
- Antigen synonyms:Acvrinp1|Membrane associated guanylate kinase WW and PDZ domain containing 2|MAGI-2|Activin receptor interacting protein 1|Membrane associated guanylate kinase 2|SSCAM|Acvri1|Membrane-associated guanylate kinase|Atrophin-1-interacting protein 1|WW and PDZ domain-containing protein 2.|Atrophin 1 interacting protein A|S SCAM|Membrane-associated guanylate kinase inverted 2|MAGI2|Atrophin-1-interacting protein A|AIP 1|ARIP1|Membrane associated guanylate kinase inverted 2|MAGI2_HUMAN|Atrophin 1 interacting protein 1|Aip-1|Membrane associated guanylate kinase WW and PDZ domain containing protein 2|ACVRIP1
- Storage buffer:Aqueous buffered solution containing 100ug/ml BSA, 50% glycerol and 0.09% sodium azide. Store at 4°C for 12 months.
- Storage temperature:Store at 4°C for 12 months
- Concentration:1 μg/μl
- Shipping temperature:4°C
- Purification:Purified by Protein A
- Pk:100 µl
AIP1 (ASK-interacting protein 1), also known as DAB2IP (DAB2 interacting protein), is a 1,189 amino acid protein that localizes to both the membrane and the cytoplasm and contains one Ras-GAP domain, one PH domain and one C2 domain. Expressed at low levels in prostate tissue, AIP1 functions as a Ras GTPase-activating protein that interacts with ASK 1 and, via this interaction, disrupts the association of ASK 1 with an inhibitory 14-3-3 complex, thereby allowing free ASK 1 to function within the cell. AIP1 exists as multiple alternatively spliced isoforms and is down-regulated in prostate cancer tissue, suggesting a role in tumor suppression. Chromosomal aberrations in the gene encoding AIP1 are associated with acute myeloid leukemia (AML), implicating a role for AIP1 fusion proteins in tumorigenesis.
Recommended Dilutions: IF(IHC-P): 1:50-200
Type: Primary
Antigen: AIP1
Clonality: Polyclonal
Clone:
Conjugation: FITC (Fluorescein Isothiocyanate)
Epitope:
Host: Rabbit
Isotype: IgG
Reactivity: Human, Mouse, Rat