- Antibody type:Primary
- Antigen name:HAAO
- Clonality:Polyclonal
- Conjugation:Alexa Fluor® 750
- Host:Rabbit
- ImmunoChemistry:Yes
- ImmunoFluorescence:Yes
- Isotype:IgG
- Reactivity:Mouse
- Western blot:Yes
- Epitope:101-200/286
- Form:Liquid
- Antigen synonyms:3-HAO|HAO|3-hydroxyanthranilic acid dioxygenase|HAD|haao|4-dioxygenase|3-hydroxyanthranilate 3,4-dioxygenase|3 hydroxyanthranilate oxygenase|3-hydroxyanthranilate oxygenase|3-hydroxyanthranilate 3|3 hydroxyanthranilic acid dioxygenase|3 hydroxyanthranilate dioxygenase|3 HAO|3HAO_HUMAN|3 hydroxyanthranilate 3 4 dioxygenase
- Modification:Unmodified
- Storage buffer:Aqueous buffered solution containing 0,01 M TBS (pH 7,4) with 1% BSA, 0,03% Proclin300 and 50% Glycerol
- Molecular weight:33 kDa
- Storage temperature:Store at −20 °C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
- Concentration:1 µg/µl
- Shipping temperature:4 °C
- Immunogen:KLH conjugated synthetic peptide derived from human HAAO
- Tested applications:ICC
- Purification:Purified by Protein A
- Pack type:Vial
- Pk:100 µl
The 3-HAO family of proteins consists of intramolecular dioxygenases that contain non-heme ferrous iron. HAAO (3-hydroxyanthranilate 3,4-dioxygenase), also known as HAO or 3-HAO, is a 286 amino acid monomeric cytoplasmic protein that belongs to the 3-HAO family. Utilizing Fe²⁺ ions as a cofactor, HAAO participates in the formation of quinolinic acid (QUIN), and excitotoxin, by catalyzing the oxidative ring opening of 3-hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde. HAAO may play a role in disorders that are associated with varying levels of QUIN expression, and is widely expressed in peripheral organs, including kidney and liver. Existing as two alternatively spliced isoforms, the gene encoding HAAO maps to human chromosome 2p21 and mouse chromosome 17 E4.
Type: Primary
Antigen: HAAO
Clonality: Polyclonal
Clone:
Conjugation: ALEXA FLUOR® 750
Public Immunogen Range: 101-200/286
Host: Rabbit
Isotype: IgG
Reactivity: Mouse