62577 Results for: "Zoutzuur&pageNo=50&view=easy"

Supplier: MARKET SOURCE PART PROCESS

1 trial bundle -1 flow cell, 1 tubing kit, 200 sterile sampling vials(15ml), 20 disinfection vials (15ml), 10 storage vials (15ml), 1 trial QC vial (19x samples), 20 syringe filters(10um), 1 vial of 3mm glass beads(50g) 1 * 1 KIT

Supplier: Thermo Orion

These bench top meters with pH/LogR module meet most challenging applications for pH, mV, ORP and LogR temperature. The meters offer interchangeable measurement modules that allow multiple users to customise four separate channels to meet their specific requirements. The LogR™ technology enables users to measure both pH and temperature using the glass-bulb of most pH electrodes – ideal for small sample volumes and samples that are difficult to clean.

Supplier: STEMCELL Technologies

Tumor necrosis factor-α (TNF-α) is a pro-inflammatory cytokine that activates NF-kB, MAPK, and PI3K/AKT pathways. Activated T cells and macrophages are the primary producers of TNF-α in response to inflammation and infectious conditions. Many other cell types have been shown to produce TNF-α, among them B cells, NK cells, mast cells, neutrophils, dendritic cells, microglia, endothelial cells, smooth muscle cells, cardiomyocytes, and fibroblasts. TNF-α has cytotoxic effects on cancer cells in vitro by stimulating anti-tumor immuno- suppressive responses. TNF-α stimulates expression of E- and P-selectins, thus facilitating adhesion of neutrophils, monocytes, and memory T cells to activated platelets and endothelial cells (Zelová and Hosek). Other effects of TNF-α include vasodilatation and edema formation.

Supplier: ProSci Inc.

Mouse Cxcl12 is a secreted and highly conserved protein which belongs to the intercrine alpha (chemokine CxC) family.CXCL12 is widely expressed in various organs including brain, kidney, skeletal muscle, heart, liver, and lymphoid organs. Cxcl12 activates the C-X-C chemokine receptor CXCR4 to induce a rapid and transient rise in the level of intracellular calcium ions and chemotaxis. It also binds to atypical chemokine receptor ACKR3 which activates the beta-arrestin pathway and acts as a scavenger receptor for SDF-1. Cxcl12 has several critical functions during embryonic development such as B-cell lymphopoiesis, myelopoiesis in bone marrow and heart ventricular septum formation. Cxcl12 plays an important role in acting as a positive regulator of monocyte migration and a negative regulator of monocyte adhesion via the LYN kinase. It stimulates migration of monocytes and T-lymphocytes through its receptors, CXCR4 and ACKR3, and decreases monocyte adherence to surfaces coated with ICAM-1, a ligand for beta-2 integrins. SDF1A/CXCR4 signaling axis inhibits beta-2 integrin LFA-1 mediated adhesion of monocytes to ICAM-1 through LYN kinase. It also plays a protective role after myocardial infarction, induces down-regulation and internalization of ACKR3 expressed in various cells and stimulates the proliferation of bone marrow-derived b progenitor cells in the presence of IL-7 as well as growth of the stromal cell-dependent B-cell clone DW34 cells.

Supplier: STEMCELL Technologies

Indian hedgehog (IHH) is one of three proteins in the hedgehog family which includes sonic hedgehog and desert hedgehog. Hedgehog proteins are important signaling molecules, acting through patched and smoothened receptors. During embryonic development, they are expressed in the fetal lung, gut, stomach, liver, kidney, and pancreas. IHH is strongly expressed in cartilage and regions of developing bone, and its signaling regulates growth and differentiation of bone tissue (Marigo et al.; Valentini et al.; St-Jacques et al.). IHH is also involved in yolk sac vasculogenesis, indicating a role in the differentiation of epiblast cells into endothelial and red blood cells (Byrd et al.). IHH induces the expression of parathyroid hormone-related peptide (PTHrP), which negatively regulates IHH during chondrocyte differentiation and proliferation (Vortkamp et al.).

Supplier: Thermo Scientific

Uv-c irradiator spot k 115 v 60 hz 1 * 1 items

Supplier: Greiner Bio-One

FOAM PLUG 50MM CEAPRENE 1 * 315 items

Supplier: Epredia

Microslide Superfrost Print 90° yellow glass cello ISO 8037/1 1,0mm 1 * 2.000 items

Supplier: Epredia

Microslide superfrost 90° cc pink glass+box cello ISO 8037/1 1,0mm 1 * 2.000 items

Supplier: Epredia

Microslide Superfrost 45° blue glass with box cello ISO 8037/1 1,0mm 1 * 2.000 items

Supplier: MACRON AVANTOR BRAND

L-Arginine hydrochloride 98.5-101.0% USP, Multi-Compendial, meets analytical specification of ChP, BP, JP, Ph. Eur., Macron Fine Chemicals™

Supplier: Epredia

Microslide Superfrost 90° CC white glass with box cello ISO 8037/1 1,0mm 1 * 2.000 items

Supplier: VELP SCIENTIFIC

The procedure for determining dietary fibre exposes the sample to a series of enzymatic digestions that simulate the real digestive process which takes place in the human or animal digestive tract, calculating the undigested residue remaining at the end of the analysis. Generally dietary fibre analysis is carried out on foods intended for human consumption whereas raw fibre analysis is carried out on animal feeds or on raw materials of vegetable origin, eg. cereals. The GDE performs enzymatic digestion, a delicate phase where samples are immersed in a thermostatic water bath and stirred. Continuous and constant sample mixing is necessary in order to prevent the sample from overheating. The unit consists of an immersion thermostat, a transparent polycarbonate tank and a VELP 6-place magnetic stirrer to ensure excellent thermoregulation and precision. The use of deionised water is recommended as it eliminates any possible cause of limescale.

Supplier: STEMCELL Technologies

Fibroblast growth factor 16 (FGF-16) is a heparin-binding member of the FGF family. FGFs possess broad mitogenic and cell survival activities and are expressed during embryonic development. FGFs act primarily on cells of mesodermal and neuroectodermal origin to regulate diverse physiological functions including angiogenesis, cell growth, pattern formation, embryonic development, metabolic regulation, cell migration, and tissue repair (Goldfarb; Green et al.). In vitro, FGF-16 has been shown to promote the proliferation of brown adipocytes and in rat embryos it is predominantly expressed in these cells. FGF-16 has also been shown to play a critical role in embryonic heart development and is thought to play a cardioprotective role after birth (Hotta et al.; Lu et al.; Wang et al.).

Supplier: Epredia

Microslide Superfrost 45° white glass with box cello ISO 8037/1 1,0mm 1 * 2.000 items

Supplier: Epredia

Microslide Superfrost 90° CC green glass with box cello ISO 8037/1 1,0mm 1 * 2.000 items

Supplier: STEMCELL Technologies

Fibroblast growth factor 8A (FGF-8A) is a member of the fibroblast growth factor (FGF) family and is an isoform of FGF-8. FGF-8A binds the FGF receptor (FGFR) and activates Ras/MAPK signaling (Hulstrand and Houston). The FGF family possesses broad mitogenic and cell survival activities (Folkman and Klagsbrun; Kimelman and Kirschner) and is involved in a variety of biological processes, including cell proliferation, differentiation, survival, and apoptosis (Folkman and Klagsbrun; Klagsbrun; Rifkin and Moscatelli). FGF-8 RNA is spliced to produce 4 protein isoforms in humans: FGF-8A, FGF-8B, FGF-8E, and FGF-8F. The functional differences are not fully understood; however, studies in zebrafish and Xenopus show that FGF-8A is required for endoderm morphogenesis and neurogenesis (Choe and Crump; Hulstrand and Houston).

Supplier: STEMCELL Technologies

R-Spondin-3 is a member of thrombospondin type 1 repeat (TSR-1) superfamily that is involved in the canonical Wnt/β-catenin signaling pathway (de Lau et al.). R-spondin proteins are characterized by two furin-like repeats at the amino terminus and thrombospondin domain located near the carboxyl terminus (de Lau et al.). R-spondin-3 expression is associated with ovarian cancer (Gu et al.), prostate cancer (Mesci et al.), and differentiation of intestinal epithelial cells in diabetes mellitus (Shan et al.). In a transgenic mice model, the expression of R-Spondin-3 induces the expansion of Lgr5+ stem cells, Paneth cells, and Lgr4+ cells, promoting the intestinal stem cell compartment (Hilkens et al.). This protein contains a His-residue tag at the carboxyl end of the polypeptide chain.

Supplier: Epredia

Microslide Superfrost 45° green glass with box cello ISO 8037/1 1,0mm 1 * 2.000 items

Supplier: Epredia

Microslide 45° frosted 20mm glass cello ISO 8037/1 1,0mm 1 * 2.000 items

Supplier: EPICENTRE

POLY(A)POLYMERASE TAILING KIT 1 * 400 µl

Supplier: MARKET SOURCE PART PROCESS

1 OFF SF10 REAGENT PUMP 100 240 VAC 1 * 1 items

Supplier: Epredia

Microslide Superfrost 45° yellow glass with box cello ISO 8037/1 1,0mm 1 * 2.000 items

Supplier: JM BROSSERIE

BRUSH CLEAN Ø50MM L=200MM PA WH 0.6MM 1 * 10 items

Supplier: Epredia

Microslide Superfrost 90° CC yellow glass with box cello ISO 8037/1 1,0mm 1 * 2.000 items

Supplier: Epredia

Microslide Superfrost 90° CC blue glass with box cello ISO 8037/1 1,0mm 1 * 2.000 items

Supplier: WATERS

Column Atlantis T3 3um 2.1 x 50mm 1 * 1 Each

Supplier: SAMCO

PIPETTE T/FER EXT/F/TIP STER PE 1.7ML 1 * 3.200 items

Supplier: Amarell

General purpose thermometer, enclosed scale, cap. lens front, red special liquid, -10+60:1C, total immersion, 200x7-8mm long, with ring at top 1 * 1 items

Supplier: ProSci Inc.

tumour Necrosis Factor- alpha (TNF- alpha) is secreted by macrophages, monocytes, neutrophils, T-cells, and NK-cells following stimulation by bacterial LPS. Cells expressing CD4 secrete TNF- alpha while cells that express CD8 secrete little or no TNF- alpha. Synthesis of TNF- alpha can be induced by many different stimuli including interferons, IL2, and GM-CSF. The clinical use of the potent anti-tumour activity of TNF- alpha has been limited by the proinflammatory side effects such as fever, dose-limiting hypotension, hepatotoxicity, intravascular thrombosis, and hemorrhage. Designing clinically applicable TNF- alpha mutants with low systemic toxicity has been of intense pharmacological interest. Human TNF- alpha that binds to murine TNF-R55 but not murine TNF-R7, exhibits retained anti-tumour activity and reduced systemic toxicity in mice compared with murine TNF- alpha, which binds to both murine TNF receptors. Based on these results, many TNF- alpha mutants that selectively bind to TNF-R55 have been designed. These mutants displayed cytotoxic activities on tumour cell lines in vitro and have exhibited lower systemic toxicity in vivo. Recombinant Human TNF- alpha High Active Mutant differs from the wild-type by amino acid subsitution of amino acids 1-7 with Arg8, Lys9, Arg10 and Phe157. This mutant form has been shown to have increased activity with less inflammatory side effects in vivo.