117412 Results for: "Rhod-FF+AM&pageNo=9"

Supplier: Enzo Life Sciences

Ikarugamycin inhibits the uptake of oxidized low-density lipoprotein in mouse macrophages. It blocks PMA and Nef-mediated cell surface CD4 down-regulation. Ikarugamycin is emerging as a general inhibitor of clathrin-coated pit-mediated endocytosis and appears to be a useful agent for studying the process of endocytosis.

Supplier: Enzo Life Sciences

Potent, cell permeable, selective, and reversible inhibitor of c-Jun N-terminal kinase (JNK) (IC50=40nM for JNK-1 and JNK-2 and 90nM for JNK-3). The inhibition is competitive with respect to ATP. Exhibits over 300-fold greater selectivity for JNK as compared to ERK1 and p38. Inhibits the phosphorylation of c-Jun and blocks the expression of IL-2, IFN-γ, TNF-α, and COX-2. Blocks IL-1-induced accumulation of phospho-Jun, induction of c-Jun transcription and anti CD3-induced apoptosis of CD4+ CD8+ thymocytes.

Supplier: Enzo Life Sciences

Cytochrome P450 inhibitor

Supplier: Enzo Life Sciences

Competitive, mechanism-based inhibitor of matrix metalloproteinases 2 and 9 (MMP-2 and MMP-9). It possesses Ki values in the nanomolar range against the gelatinases (14nM for MMP-2; 600nM for MMP-9), but in the micromolar range against other metalloproteinases (206µM for MMP-1, 15µM for MMP-3, 96µM for MMP-7, and 4µM for ADAM17/TACE). This inhibitor has also been used in vitro, in vivo, and in tissue culture. In vivo, it is metabolized to an even more potent gelatinase inhibitor.

Supplier: Enzo Life Sciences

BIBB 515 is a potent and selective inhibitor of 2,3-oxidosqualene cyclase (OSC) in vivo. BIBB 515 inhibits LDL production in both normolipemic and hyperlipemic hamsters and may represent a novel approach for the development of lipid lowering drugs.

Supplier: Enzo Life Sciences

High potency synthetic agonist at GPR40.

Supplier: Enzo Life Sciences

Retinoic acid receptor ligand.

Supplier: Enzo Life Sciences

Unsaturated analog of endogenous sleep inducing lipid.

Supplier: Enzo Life Sciences

Endocannabinoid.

Supplier: Enzo Life Sciences

Eicosapentaenoyl ethanolamide ≥98% (by TLC)

Supplier: Enzo Life Sciences

Highly potent inhibitor of VEGFR-1 (IC50=130nM), VEGFR-2 (IC50=23nM) and VEGFR-3 (IC50=18nM). At higher concentrations it inhibits PDGFR-β (640nM), c-Kit (236nM) and CSF-1R (380nM).

Supplier: Enzo Life Sciences

CaM kinase kinase inhibitor

Supplier: Enzo Life Sciences

Potent, dual site (ATP domain and substrate-binding domain) Src and Lck kinase inhibitor (IC50=44 and 88nM respectively). VEGFR2 IC50=0.32μM; c-fms IC50=30μM.

Supplier: Enzo Life Sciences

Potent, selective and irreversible inhibitor of MAG lipase (IC50=8nM vs 4µM for FAAH). JZL-184-treated mice displayed a number of CB1-dependent behavioral effects including analgesia, hypothermia and hypomotility as well as increased levels of 2-arachidonoylglycerol in the brain ( approx. 8-fold, with no effect on anandamide levels). JZL-184 produces a rapid and sustained blockade of brain 2-AG hydrolase activity in mice. It blocks neuropathic pain and enhances retrograde endocannabinoid signaling.

Supplier: Enzo Life Sciences

BML-277 is a highly selective inhibitor of Chk2 (IC50=15nM). It displays potent radioprotective activity and prevents apoptosis of human T cells subjected to ionizing radiation (EC50= 3-7.6µM). Useful tool for dissecting the role of Chk2 in cellular signaling.

Supplier: Enzo Life Sciences

Potent inhibitor of farnesyltransferase in isolated enzyme assays (IC50=30 nM) and in whole cells. Inhibition of farnesyltransferase is selective over geranylgeranyltransferase I and II (IC50=35.8 µM and 67 µM respectively). α-Hydroxyfarnesylphosphonic acid inhibited (1 µM) Ras processing in Ha-ras-transformed NIH 3T3 fibroblasts.

Supplier: Enzo Life Sciences

Originally isolated from Galiella rufa as a plant growth regulator. Inhibits IL-6 mediated signal transduction by blocking the binding of the activated STAT3 dimers to their DNA binding sites without inhibiting the tyrosine and serine phosphorylation site of the STAT3 transcription factor.

Supplier: Enzo Life Sciences

Yellow oil

Supplier: Enzo Life Sciences

Anti-inflammatory and anti-diabetic.

Supplier: Enzo Life Sciences

5-HT2c inhibitor

Supplier: Enzo Life Sciences

Potent inhibitor of CDK4 / cyclin D1 (IC50 = 59nM). Inhibits human cytomegalovirus (HCMV) replication in cell culture (IC50 = 200nM).

Supplier: Enzo Life Sciences

White to off-white solid (sub-milligram quantities will appear as clear film)

Supplier: Enzo Life Sciences

White to off-white crystalline solid

Supplier: Enzo Life Sciences

Antibiotic.

Supplier: Enzo Life Sciences

Antibiotic. Dominant analog of the reveromycin complex. Inhibitor of the mitogenic activity of epidermal growth factor (EGF). G1 phase cell cycle inhibitor, selectively inhibiting isoleucyl-tRNA synthetase. Displays antiproliferative as well as potent antifungal activity. Induces apoptosis in osteoclasts thus inhibiting bone resorption.

Supplier: Enzo Life Sciences

V-ATPase inhibitor.

Supplier: Enzo Life Sciences

β-Lactam antibiotic. Inhibits bacterial cell-wall synthesis (peptidoglycan cross-linking). Inactivates transpeptidases on the inner surface of the bacterial cell membrane. Effective against Gram-negative and Gram-positive bacteria.

Supplier: Enzo Life Sciences

Inhibitor of NF-κB activation (induced by either PMA or TNF-α) in various cell types.

Supplier: Enzo Life Sciences

Anti-inflammatory and antioxidant.

Supplier: Enzo Life Sciences

Cell permeable modulator of Ins(1,4,5)-P3-induced Ca²⁺ release. A prototype drug for a group of structurally related calcium channel blockers in human platelets. Has been shown, in the absence of other stimuli, to activate TRPV1, V2 and V3, but not TRPV4, V5 and V6 expressed in HEK 293 cells. Potentiates the effect of capsaicin, protons and heat on TRPV1. It was originally introduced as an IP3 receptor blocker and subsequently as an inhibitor of store-operated Ca²⁺ entry (75µM).