39796 Results for: "L-\u03B1-Glycerophosphoryl+Choline,+Cadmium+Chloride+Complex"

Supplier: Bioss

mTOR controls cell growth, in part by regulating p70 S6 kinase alpha (p70alpha) and eukaryotic initiation factor 4E binding protein 1 (4EBP1). Raptor is a 150 kDa mTOR binding protein that also binds 4EBP1 and p70alpha. The binding of Raptor to mTOR is necessary for the mTOR-catalyzed phosphorylation of 4EBP1 in vitro, and it strongly enhances the mTOR kinase activity toward p70alpha. Rapamycin or amino acid withdrawal increases, whereas insulin strongly inhibits, the recovery of 4EBP1 and raptor on 7-methyl-GTP Sepharose. Partial inhibition of raptor expression by RNA interference (RNAi) reduces mTOR-catalyzed 4EBP1 phosphorylation in vitro. RNAi of C. elegans raptor yields an array of phenotypes that closely resemble those produced by inactivation of Ce-TOR. Thus, raptor is an essential scaffold for the mTOR-catalyzed phosphorylation of 4EBP1 and mediates TOR action in vivo.

Supplier: Abcam

Knockout Tested Rabbit recombinant monoclonal MK14 antibody. Suitable for IHC-P, WB, ICC/IF and reacts with Human, Mouse, recombinant full length protein - Human samples. Cited in 43 publications.

Supplier: Bioss

Clathrin-mediated endocytosis is the pathway by which many receptors for nutrients and hormones are internalized to be recycled or down-regulated. During formation of clathrin coated membranes, clathrin co-assembles with heterotetrameric molecules known as assembly polypeptides (APs) or adaptors which form a layer of protein coat between the clathrin lattice and the membrane. There are two characterized adaptors AP1 and AP2. AP1 is associated with clathrin coated vesicles at the trans-Golgi network and AP2 is associated with the endocytic clathrin coated vesicles at the plasma membrane and has been shown to specifically interact with Shc and EGF receptor. AP2 is composed of four subunits, two separate 100 kDa gene products with similar domain structures (alpha and beta adaptin) and a 50 and 17 kDa subunit. There are two alpha-adaptin genes, alpha A and alpha C which have a tissue specific pattern of expression.

Supplier: Oxford Nanopore Technologies

GridION™ - a self-contained, easily deployable DNA/RNA benchtop nanopore sequencer.

Supplier: Abcam

Rabbit Polyclonal APC1 phospho S355 antibody. Suitable for WB and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human ANAPC1 phospho S355 aa 350-400 conjugated to Keyhole Limpet Haemocyanin.

Supplier: Abcam

Mouse Monoclonal HEC1/HEC antibody. Carrier free. Suitable for IP, Flow Cyt, WB, ICC/IF and reacts with Human, Pig samples. Cited in 114 publications. Immunogen corresponding to Recombinant Fragment Protein within Human NDC80 aa 50 to C-terminus.

Supplier: Bioss

mTOR controls cell growth, in part by regulating p70 S6 kinase alpha (p70alpha) and eukaryotic initiation factor 4E binding protein 1 (4EBP1). Raptor is a 150 kDa mTOR binding protein that also binds 4EBP1 and p70alpha. The binding of Raptor to mTOR is necessary for the mTOR-catalyzed phosphorylation of 4EBP1 in vitro, and it strongly enhances the mTOR kinase activity toward p70alpha. Rapamycin or amino acid withdrawal increases, whereas insulin strongly inhibits, the recovery of 4EBP1 and raptor on 7-methyl-GTP Sepharose. Partial inhibition of raptor expression by RNA interference (RNAi) reduces mTOR-catalyzed 4EBP1 phosphorylation in vitro. RNAi of C. elegans raptor yields an array of phenotypes that closely resemble those produced by inactivation of Ce-TOR. Thus, raptor is an essential scaffold for the mTOR-catalyzed phosphorylation of 4EBP1 and mediates TOR action in vivo.

Supplier: Abcam

Mouse Monoclonal CD74 antibody. Suitable for IHC-P, ICC/IF, WB and reacts with Human samples. Cited in 11 publications. Immunogen corresponding to Synthetic Peptide within Human CD74 aa 1-50 conjugated to Keyhole Limpet Haemocyanin.

Supplier: Bioss

mTOR controls cell growth, in part by regulating p70 S6 kinase alpha (p70alpha) and eukaryotic initiation factor 4E binding protein 1 (4EBP1). Raptor is a 150 kDa mTOR binding protein that also binds 4EBP1 and p70alpha. The binding of Raptor to mTOR is necessary for the mTOR-catalyzed phosphorylation of 4EBP1 in vitro, and it strongly enhances the mTOR kinase activity toward p70alpha. Rapamycin or amino acid withdrawal increases, whereas insulin strongly inhibits, the recovery of 4EBP1 and raptor on 7-methyl-GTP Sepharose. Partial inhibition of raptor expression by RNA interference (RNAi) reduces mTOR-catalyzed 4EBP1 phosphorylation in vitro. RNAi of C. elegans raptor yields an array of phenotypes that closely resemble those produced by inactivation of Ce-TOR. Thus, raptor is an essential scaffold for the mTOR-catalyzed phosphorylation of 4EBP1 and mediates TOR action in vivo.

Supplier: Bioss

mTOR controls cell growth, in part by regulating p70 S6 kinase alpha (p70alpha) and eukaryotic initiation factor 4E binding protein 1 (4EBP1). Raptor is a 150 kDa mTOR binding protein that also binds 4EBP1 and p70alpha. The binding of Raptor to mTOR is necessary for the mTOR-catalyzed phosphorylation of 4EBP1 in vitro, and it strongly enhances the mTOR kinase activity toward p70alpha. Rapamycin or amino acid withdrawal increases, whereas insulin strongly inhibits, the recovery of 4EBP1 and raptor on 7-methyl-GTP Sepharose. Partial inhibition of raptor expression by RNA interference (RNAi) reduces mTOR-catalyzed 4EBP1 phosphorylation in vitro. RNAi of C. elegans raptor yields an array of phenotypes that closely resemble those produced by inactivation of Ce-TOR. Thus, raptor is an essential scaffold for the mTOR-catalyzed phosphorylation of 4EBP1 and mediates TOR action in vivo.

Supplier: Antibodies.com

Rabbit monoclonal [ARC0933] antibody to Reptin/TIP49B/RUVB2 for WB with samples derived from Human, Mouse and Rat.

Supplier: Antibodies.com

Rabbit polyclonal antibody to IkappaB-alpha (phospho Tyr305) for WB, IHC and ELISA with samples derived from Human, Mouse and Rat.

Supplier: Antibodies.com

Mouse monoclonal [PCRP-KIAA1967-1D10] antibody to DBC-1 for Flow Cytometry and IHC-P with samples derived from Human.

Supplier: ProSci Inc.

The RB6-8C5 monoclonal antibody reacts with the mouse Ly-6G (also known as Gr-1). The Ly-6G protein is a myeloid differentiation antigen of 21 to 25 kDa, expressed in a regulated manner by the myeloid lineage in the bone marrow, where the level of antigen expression is correlated with the granulocyte maturation and differentiation. In the bone marrow, the antigen is not expressed by the erythroid cells. From the peripheric cells, RB6-8C5 binds with monocytes, neutrophils and eosinophils.As a marker for the mouse monocytes, macrophages and granulocytes, the RB6-8C5 antibody is usually combined with M1/70, a macrophage labeling antibody (Anti-CD11b), for phenotypic analysis.

Supplier: ProSci Inc.

The RB6-8C5 monoclonal antibody reacts with the mouse Ly-6G (also known as Gr-1). The Ly-6G protein is a myeloid differentiation antigen of 21 to 25 kDa, expressed in a regulated manner by the myeloid lineage in the bone marrow, where the level of antigen expression is correlated with the granulocyte maturation and differentiation. In the bone marrow, the antigen is not expressed by the erythroid cells. From the peripheric cells, RB6-8C5 binds with monocytes, neutrophils and eosinophils.As a marker for the mouse monocytes, macrophages and granulocytes, the RB6-8C5 antibody is usually combined with M1/70, a macrophage labeling antibody (Anti-CD11b), for phenotypic analysis.

Supplier: Antibodies.com

Mouse monoclonal [134-2C2] antibody to CD26 for Flow Cytometry, IF and IHC with samples derived from Human.

Supplier: Antibodies.com

Mouse monoclonal [IGA/515] antibody to CD79a for Flow Cytometry, IF and IHC-P with samples derived from Human.

Supplier: Antibodies.com

Mouse monoclonal [193-27] antibody to CD59 for Functional Studies, Flow Cytometry and IF with samples derived from Human.

Supplier: Antibodies.com

Rabbit polyclonal antibody to SFPQ for WB, IHC, ICC/IF and IP with samples derived from Human, Mouse and Rat.

Supplier: HONEYWELL SAFETY

These disposable nitrile gloves offer better mechanical resistance than latex gloves.

Supplier: Antibodies.com

Rat monoclonal [H194-112] antibody to DPP4 (PE) for Flow Cytometry with samples derived from Mouse.

Supplier: Antibodies.com

Mouse monoclonal [MEM-129] antibody to CD59 for Flow Cytometry and Functional Studies with samples derived from Porcine and Human.

Supplier: Antibodies.com

Recombinant mouse monoclonal [rIGA/764] antibody to CD79a for Flow Cytometry, IF and IHC-P with samples derived from human.

Supplier: Antibodies.com

Rat monoclonal [H194-112] antibody to DPP4 for IP, Flow Cytometry and IHC-Fr with samples derived from Mouse.

Supplier: Antibodies.com

Rabbit monoclonal [ARC0876] antibody to TRAP1 for WB and IP with samples derived from Human and Mouse.

Supplier: Antibodies.com

Rabbit monoclonal [ARC1629] antibody to Proteasome 20S LMP2 for WB and IHC with samples derived from Human, Mouse and Rat.

Supplier: Antibodies.com

Mouse monoclonal [193-27] antibody to CD59 for Functional Studies, Flow Cytometry and IF with samples derived from Human.

Supplier: Antibodies.com

Rabbit monoclonal [ARC0788] antibody to SFPQ for WB, IHC and ICC/IF with samples derived from Human, Mouse and Rat.

Supplier: Antibodies.com

Mouse monoclonal [DPP4/7415] antibody to DPP4 for WB and IHC-P with samples derived from Human.

Supplier: Antibodies.com

Rabbit polyclonal antibody to LAMTOR1 for WB, IHC and ICC/IF with samples derived from Human, Mouse and Rat.