Supplier: Avantor Fluid Handling

Versatile pumps for accurate fluid delivery – with an intuitive touch-screen interface.

Supplier: STEMCELL Technologies

Human Interleukin 4 (IL-4) is important for immune responses to helminth infection as well as in allergic responses (Olpihant et al.). The IL-4 receptor consists of a heterodimer of IL-4Ra and common gamma chain. IL-4 receptor engagement leads to the activation of JAK1/3 and the recruitment of STAT6 and IRS1/2 (Nelms et al.). IL-4 drives immunoglobulin class switching in B cells (to IgE, IgG4), mast cell hyperplasia, mucus production, and the differentiation of naïve T cells into Th2 cells, which produce IL-4, IL-5, IL-10, and IL-13 (Bao et al.; Nelms et al.; Olpihant et al.). In addition to Th2 cells, IL-4 is produced by CD4+ NK T cells, γ/δ T cells, activated basophils, eosinophils, and mast cells. Human IL-4 does not cross-react with mouse cells (Park et al.).

Supplier: 3M

3M™ SecureFit™ safety helmet X5500 series provides secure, comfortable, and adjustable head protection for workers in a variety of situations. The helmets feature adjustable positioning and easy-turning, 4-point ratchet suspension systems with the exclusive 3M™ pressure diffusion technology. The X5500 series also feature 3M™ UVicator™ Sensors that indicate damaging levels of ultraviolet (UV) light.

Supplier: Diversey

Solo is a hard water tolerant, low foaming, low freezing point liquid caustic detergent for dairy heat treated surface CIP applications. Solo is used for single stage CIP recovery cleaning in a wide range of applications, including cold surfaces as well. Solo can be used to clean a wide range of applications in dairy, e.g. HTST, homogenisers, storage, mixing and ageing tanks used in ice cream manufacture. Solo can be used to clean a wide range of applications across the food and beverage industries, e.g. vegetable evaporators in processed foods plants.

Supplier: Thermo Fisher Scientific

The Thermo Scientific KingFisher Apex represents the pinnacle of automated purification for DNA, RNA, proteins, and cells. Building on decades of KingFisher product value and excellence, we’ve combined superior instrument capabilities with complete touch screen-based control to deliver unrivalled flexibility and performance. The KingFisher Apex makes sample prep simple.

Supplier: Copan

Rapid DNA testing made portable. MicroFLOQ® is an innovative DNA collection tool featuring a micro flocked swab-head co-developed* by French Gendarmerie Forensic Research Institute (IRCGN™) and Copan.

Supplier: ENZO LIFE SCIENCES

PCR/Gel Clean Up Kits are quick and simple kits for purifying DNA from PCR, gels and labelling reactions for a variety of downstream applications.

Supplier: Thermo Scientific

Thermo Scientific™ TDE Series ultra-low temperature freezers, powered by H-drive, feature four upright models with 5 Inner doors, maximizing storage capacity from 30000 up to 60000 2 ml vials. The TDE Series is a sustainable and reliable solution with ultimate sample security and operational savings for every lab. Sustainability features include natural refrigerants and water-blown foam, compliant with many sustainability standards.

Supplier: Sartorius Balances

The Cubis® II laboratory balances are modular, therefore they allow to choose between applications and configurations which suit the best to the needs. These balances can be configured at the level of display, draftshields, software applications and hardware functions.

Supplier: Thermo Scientific

Thermo Scientific™ TSX Series high-performance pharmacy refrigerators are designed with features that support sample protection and sustainability objectives for the storage of pharmaceuticals, vaccines, chemotherapy and other medical and pharmacy-grade storage requiring 2 to 8 °C. The Series’ V-drive technology is designed to provide temperature uniformity that continually adapts to user patterns, offering significant energy savings without compromising protection. Certified to NSF/ANSI 456 Vaccine Storage standard, the TSX series can help you meet regulations and guidelines from the CDC, World Health Organisation, and other Health Ministries on vaccine storage and handling. The TSX Series delivers the performance and quality you need, in addition to the low sound, low energy, and exceptional user experience you deserve.

Supplier: Sartorius Balances

The Cubis® II laboratory balances are modular, providing choice between applications and configurations that best suit the users' needs. These balances can be configured at the level of display, draftshields, software applications and hardware functions. The Cubis® II range of high-capacity micro balances with a maximum load between 32 and 111 g and a readability between 0,001 mg and 0,002 mg provide the ideal choice for a broad range of applications.

Supplier: BIOTIX

This new generation of tips form an excellent seal on both single- and multi-channel pipettes guaranteeing total recovery of the sample whilst protecting the technician against the risks of repetitive strain injury. The tips are manufactured with proprietary technologies for increased pipetting accuracy and precision.

Supplier: LAUDA

The Alpha cooling thermostats have an easy to use control console featuring three button operation and large, clear LED display, ensuring easy navigation through the menu. The thermostats are suitable for use with non flammable liquids (water, water/glycol mixtures). Units can provide both internal and external thermostating. Temperature stability of ±0,05 K gives precise heating and cooling suitable for a wide range of applications. The automatic cooling system enables cooling throughout the entire temperature range of −25 to +100 °C. All cooling thermostats contain a compressor system which can be switched on or off as required, thus conserving energy and saving wear and tear on the compressor to give a longer working life.

Supplier: STEMCELL Technologies

Interferon-alpha (IFN-α) is a type I interferon, produced by virus-infected cells, and is released as a soluble factor to initiate antiviral responses (Isaacs and Lindenmann). IFN-α2 is the most potent IFN-α used in fundamental research and in most clinical applications. The best-known IFN-α2 subvariants, 2A and 2B, differ by only one or two amino acids at positions 23 and/or 34 of the mature protein (von Gabain et al.). Type I IFNs exert potent antitumor activity by increasing the cytotoxic activity of NK and T cells, as well as by inhibiting the proliferation of cancer cells (Paul et al.). Additionally, it has been shown that proinflammatory IFN-α modulates the function of B cells in patients with systemic lupus erythematosus (Chang et al.), and pegylated forms of IFN-alpha 2A and 2B have implications in the treatment of hepatitis C (Foster et al.).

Supplier: STEMCELL Technologies

Interleukin 2 (IL-2) is a monomeric cytokine that was originally identified as a T cell growth factor (Gaffen and Liu). It binds to a heterotrimeric receptor consisting of CD25, CD122, and CD132. Upon binding, it activates JAK3-, STAT5-, and AKT-dependent signaling pathways, which results in cellular proliferation and survival (Ma et al.). The majority of IL-2 is secreted by activated CD4+ and CD8+ T cells, although B cells and dendritic cells were found to produce IL-2 in small amounts. IL-2 downregulates immune responses to prevent autoimmunity during thymic development, influences the development of CD4+CD25+ regulatory T cells, and affects development of follicular helper T cells. IL-2 also controls inflammation by inhibiting Th17 differentiation (Banchereau et al.). Targeted deletions of the IL-2 gene in mice resulted in development of autoimmune hemolytic anemia, followed by ulcerative colitis. Similar effects were observed in mice that were deficient in IL-2 receptor α (Gaffen and Liu).

Supplier: IKA

Compact recirculating chiller with powerful 400 W cooling capacity, designed for simple cooling tasks down to –10 °C. The RC 2 lite is the perfect peripheral device for the cooling of rotary evaporators, reflux condensers or as a cooling source for devices that dissipate heat with the help of a heat exchanger (double-walled grinding containers, cooled incubators, laboratory reactors, cooling coils). The easily accessible and easy-to-clean mesh filter along with low filling volume of just one litre enables fast cooling. Thanks to the natural refrigerant R290, the RC 2 lite is remarkably environmentally friendly.

Supplier: STEMCELL Technologies

Interferon-alpha (IFN-α) is a type I interferon, produced by virus infected cells, and is released as a soluble factor to initiate antiviral responses (Isaacs and Lindenmann). IFN-α2 is the most potent IFN-α used in fundamental research and in most clinical applications. The best known IFN-α2 subvariants, 2A and 2B, differ by only one or two amino acids at positions 23 and/or 34 of the mature protein (von Gabain et al.). Type I IFNs exert potent antitumor activity by increasing the cytotoxic activity of NK and T cells, as well as inhibiting the proliferation of cancer cells (Paul et al.). Additionally, it has been shown that proinflammatory IFN-α modulates the function of B cells in patients with systemic lupus erythematosus (Chang et al.) and pegylated form of IFN-α 2A and 2B has implications in the treatment of Hepatitis C (Foster et al.).

Supplier: Oxford Nanopore Technologies

Rapid Sequencing Kits offer a simple and rapid library preparation method for genomic DNA sequencing on MinION™ devices.

Supplier: VWR Chemicals

Easy to use method for isolation up to 100 µg of total RNA from cultured eukaryotic cells and soft tissues <1×10⁷ cells or 30 mg tissue.

Supplier: MIELE

Miele PG 8583 Laboratory glasswasher represents a professional solution for laboratory glassware for analytical experiments. This approach is particularly gentle on materials and is recommended by leading manufacturers of laboratory glassware.

Supplier: Merck

Fast method development of complex samples across the pH range from 1,5 to 10,5 with different mobile phases and temperature conditions.
Purospher® STAR RP-18 endcapped HPLC columns are designed for universal use. Basic, neutral and metal-chelating compounds can easily be separated with simple mobile phases – naturally without peak tailing. Thanks to its outstanding performance and stability, Purospher® STAR RP-18 endcapped offers maximum flexibility in method development. Robust methods can be developed over the entire pH range from 1,5 to 10,5. High pH-stability allows the separation of strongly basic compounds with alkaline eluents. The combination of high purity silica, best all-round retention characteristics, outstanding pH stability up to pH 10,5, and suitability for up to 100% aqueous mobile phases, make Purospher® STAR RP-18 endcapped an all-round top performance column, almost universal in its range of applications.

Supplier: VWR Collection

The M9 UV/Vis Spectrophotometer is a double beam UV/Vis spectrophotometer with a variable spectral bandwidth for routine and advanced applications.

Supplier: VWR Collection

These tips are made of high quality, 100% pure, virgin medical grade PP. Made in the highest quality moulds, these tips can be used whenever the work demands a higher standard.

Supplier: VWR Collection

The VWR® thermal cycler family combines high quality engineering with a comprehensive range of block formats. The UNO cycler is designed around a powerful, yet easy to use, software interface, and uses the same platform for both 96-well and 384-well formats. The Doppio, with two independent high speed 48-well blocks in one system, offers the optimum solution for maximum flexibility within a minimum footprint. Because of the special design of the heated lid, the height adjusts automatically to the different tube sizes.

Supplier: STEMCELL Technologies

RANTES (regulated upon activation, normal T cell expressed and secreted), also known as CCL5, is a member of the CC family of chemokines and is able to recruit leukocytes to sites of inflammation (Schall et al.). RANTES is secreted by T lymphocytes, macrophages, platelets, synovial fibroblasts, tubular epithelium, and certain types of tumor cells (Aldinucci and Colombatti; Soria and Ben-Baruch). This chemokine exerts its effect by interacting with the chemokine receptors CCR1, CCR3, CCR4, and CCR5. RANTES plays an active role in recruiting a variety of leukocytes into inflammatory sites, including T cells, macrophages, eosinophils, and basophils. In collaboration with certain cytokines that are released by T cells such as IL-2 and IFN-γ, RANTES also induces the activation and proliferation of NK cells to generate CC chemokine-activated killer cells, which are highly cytolytic (Lv et al.; Maghazachi et al.). It has been shown that RANTES produced by CD8+ T cells inhibits HIV infection of primary human peripheral blood mononuclear cells (Appay and Rowland-Jones; Cocchi et al.).

Supplier: STEMCELL Technologies

Interleukin 6 (IL-6) is a pleiotropic growth factor with the wide range of biological activities in immune regulation, hematopoiesis, and oncogenesis. IL-6 is produced by a variety of cell types including T cells, B cells, monocytes and macrophages, fibroblasts, hepatocytes, vascular endothelial cells, and various tumor cell lines. On its own or in combination with other factors such as IL-2 and interferon-γ, IL-6 stimulates the proliferation of B cells, T cells, and hybridoma cells (Hirano et al.; Mihara et al.; Tanaka et al). In combination with cytokines such as IL-3, GM-CSF and SCF, IL-6 has been shown to promote hematopoietic progenitor cell proliferation and differentiation in vitro. IL-6 signals through a cell surface type I cytokine receptor complex consisting of the ligand-binding IL-6α (CD126) and the signal-transducing gp130 subunits. The binding of IL-6 to its receptor system includes activation of JAK/STAT signaling pathway (Mihara et al.; Peters et al.; Tanaka et al.).

Supplier: STEMCELL Technologies

Bone morphogenetic protein 4 (BMP-4) is a member of the highly conserved transforming growth factor β (TGF-β) superfamily. Mature BMP-4 is a disulfide-linked homodimeric protein consisting of two 116-amino-acid residue subunits, and is generated by the proteolytic removal of the signal peptide and propeptides (Xiao et al.). BMP-4 binds to type I and type II receptors on cells. This binding results in the phosphorylation of receptor 1, which in turn results in the phosphorylation of Smad proteins, which then go on to act as transcription factors (Zhang et al.). BMPs have been shown to be key regulators of embryogenesis and are known to play a role in the growth and differentiation of various cell types, including embryonic stem (ES) cells, induced pluripotent stem (iPS) cells, mesenchymal cells, epithelial cells, hematopoietic cells, and neuronal cells (Chadwick et al.; Graham et al.; Jones et al.; Lengerke et al.; Zhang et al.).

Supplier: STEMCELL Technologies

RANTES (regulated upon activation, normal T cell expressed and secreted), also known as CCL5, is a member of the CC family of chemokines and is able to recruit leukocytes to sites of inflammation (Schall et al.). RANTES is secreted by T lymphocytes, macrophages, platelets, synovial fibroblasts, tubular epithelium, and certain types of tumor cells (Aldinucci and Colombatti; Soria and Ben-Baruch). This chemokine exerts its effect by interacting with the chemokine receptors CCR1, CCR3, CCR4, and CCR5. RANTES plays an active role in recruiting a variety of leukocytes into inflammatory sites, including T cells, macrophages, eosinophils, and basophils. In collaboration with certain cytokines that are released by T cells such as IL-2 and IFN-γ, RANTES also induces the activation and proliferation of NK cells to generate CC chemokine-activated killer cells, which are highly cytolytic (Lv et al.; Maghazachi et al.). It has been shown that RANTES produced by CD8+ T cells inhibits HIV infection of primary human peripheral blood mononuclear cells (Appay and Rowland-Jones; Cocchi et al.).

Supplier: STEMCELL Technologies

Human Interleukin 4 (IL-4) is important for immune responses to helminth infection as well as in allergic responses (Olpihant et al.). The IL-4 receptor consists of a heterodimer of IL-4Ra and common gamma chain. IL-4 receptor engagement leads to the activation of JAK1/3 and the recruitment of STAT6 and IRS1/2 (Nelms et al.). IL-4 drives immunoglobulin class switching in B cells (to IgE, IgG4), mast cell hyperplasia, mucus production, and the differentiation of naïve T cells into T helper type 2 (Th2) cells, which produce IL-4, IL-5, IL-10, and IL-13 (Bao et al.; Olpihant et al.; Nelms et al.). In addition to Th2 T cells, IL-4 is produced by CD4+ NK T cells, γ/δ T cells, activated basophils, eosinophils, and mast cells. IL-4 consists of 130 amino acids with a predicted molecular weight of 15.1 kDa. Human IL-4 does not cross-react with mouse cells (Park et al.). This product is animal component-free.

Supplier: Corning

The HTS Transwell-96 permeable support has an array of 96-wells with membrane inserts connected by a rigid, robotics-friendly tray that enables all 96 inserts to be handled as a single unit.