11723 Results for: "Enzo Life Sciences"

Supplier: Enzo Life Sciences

Produced in E. coli.

Supplier: Enzo Life Sciences

Produced in E. coli. Human SUMO-2 is fused to a His-tag.

Supplier: Enzo Life Sciences

Produced in E. coli.

Supplier: Enzo Life Sciences

Produced in E. coli.

Supplier: Enzo Life Sciences

FAT10 and FAT10 conjugates are rapidly degraded by the proteasome, a process which may involve interaction with NUB1L. FAT10 is also of interest in apoptosis.

Supplier: Enzo Life Sciences

The assembly of individual mammalian proteasome subunits into catalytically active 20S proteasome is a complex process, with biogenesis of the mammalian 20S proteasome occuring via precursor complexes containing α and unprocessed β subunits. The pro-peptides of the β subunits are thought to prevent premature conversion of the precursor complexes into matured particles and are needed for efficient β subunit incorporation. The complex biogenesis is tightly regulated, requiring additional components such as the maturation factor POMP (proteasome maturation protein), an ubiquitous protein in eukaryotic cells. Mammalian POMP is functionally related to but not interchangable with its yeast homologue Ump1. POMP is associated purely with the precursor intermediates and is degraded upon final maturation. Northern blot experiments have revealed that expression of POMP is induced after treatment with interferon γ.

Supplier: Enzo Life Sciences

Host: Rabbit

Supplier: Enzo Life Sciences

Produced in E. coli. Human BAP1 is fused at the N-terminus to a His-tag.

Supplier: Enzo Life Sciences

Complement factor C9 is a 71kDa single-chain ellipsoid a-globular molecule of 558 amino acids including a leader sequence of 20 amino acids. C9 binds the C5b8 complex on membranes and has the unique function of forming tubular structures containing between 12 and 18 monomers, closely resembling the membrane attack complex (MAC). The primary site of synthesis is hepatocytes; secondary sites are monocytes, fibroblasts and glial cells. The normal level of C9 in plasma is 60 µg/ml, and the level is upregulated from hepatocytes by IFN-γ.

Supplier: Enzo Life Sciences

A Real-time Mitochondrial membrane Potential Assay with Superior Sensitivity. Suitable for high-throughput applications.

Supplier: Enzo Life Sciences

Recommended Applications: ICC, IHC, IP, WB, Immunoelectron microscopy

Supplier: Enzo Life Sciences

The lymphocyte activation gene-3 (LAG-3, CD223), a member of the immunoglobulin superfamily (IgSF) related to CD4, binds to the major histocompatibility complex (MHC) class II molecules but with higher affinity than CD4. Several alternative mRNA splice-variants of human LAG-3 have been described, two of them encoding potential secreted forms: LAG-3V1 (i.e. the D1-D2 domains of the protein, 36 kDa) and LAG-3V3 (D1-D3, 52 kDa). The longer form was detected by ELISA in the serum of healthy individuals as well as of tuberculosis patients with a favorable outcome. LAG-3 expression by T cell clones correlated with IFN-γ production, and hence soluble LAG-3 has been suggested as a serological marker of Th1 responses.

Supplier: Enzo Life Sciences

Host: Mouse, Isotype: IgG2a lambda

Supplier: Enzo Life Sciences

Pig neutrophil gelatinase-associated lipocalin (NGAL; also lipocalin 2 or siderocalin) may, by analogy with its homologues in other mammalian species, be released from activated neutrophils in inflammation or infection from certain epithelial cancers, and more dramatically, from renal tubular cells in response to ischemic or nephrotoxic injury.

Supplier: Enzo Life Sciences

The EFLUXX-ID® Multidrug Resistance Assay Kit allows for functional detection of all three clinically relevant ABC transporter proteins MDR1 (p-glycoprotein), MRP1/2, and BCRP. The assay uses a hydrophobic, non-fluorescent compound that readily penetrates the cell membrane, where it is hydrolyzed to a hydrophilic fluorescent dye by intracellular esterases.

Supplier: Enzo Life Sciences

The ROS-ID® Hypoxia/Oxidative Stress Detection Kit is a specific detection system designed for functional detection of hypoxia and oxidative stress levels in live cells (both suspension and adherent) using fluorescent microscopy or flow cytometry.

Supplier: Enzo Life Sciences

Host: Rabbit

Supplier: Enzo Life Sciences

Assay Buffer from the Ubiquitinylation Kits. Packaged as 5×1 ml.

Supplier: Enzo Life Sciences

Produced in E. coli. Human IL-1β (interleukin-1β) (aa 117-270) is fused to a linker peptide (10 aa) and an N-terminal FLAG®-tag.

Supplier: Enzo Life Sciences

The COP9 signalosome, once defined as a repressor complex of light activated development in Arabidopsis, has recently been found in humans and is probably present in most multicellular organisms. The COP9 signalosome is closely related to the lid sub-complex of the 26S proteasome in structural composition and probably shares a common evolutionary ancestor. A multifaceted role of the COP9 signalosome in cell-signalling processes is hinted at by its associated novel kinase activity, as well as the involvement of its subunits in regulating multiple cell-signalling pathways and cell-cycle progression. The molecular genetic studies in Arabidopsis suggest that the complex functions as part of a highly conserved regulatory network, whose physiological role in animals has yet to be determined. The COP9 signalosome, also known as the the COP9 complex and JAB1-containing signalosome, is a conserved nuclear protein complex found in plants and animals. It is composed of eight distinct subunits, designated S1 to S8 (very recently re-designated Csn1-Csn82) according to the molecular weight of the mammalian complex subunits. Subunit composition and the subunit sequences are substantially conserved between the mammalian and the plant complexes, implying that the complex has a conserved cellular function in higher eukaryotic organisms. Subunit 1 (Csn1) was previously identified as GPS1, which was isolated by its ability to rescue the lethality of a S. cerevisiae mutant deleted for the α-subunit of trimeric G protein. Transient expression of full length GPS1 in mammalian cells was shown to inhibit JNK1 and to repress JUN-dependent promoter activity. Csn1 shows homology to 19S proteasome regulatory subunit Rpn7 (S10a).

Supplier: Enzo Life Sciences

Cannabinoid receptor ligand

Supplier: Enzo Life Sciences

IHC universal negative control reagent is specifically designed to work with rabbit, mouse and goat antibodies.

Supplier: Enzo Life Sciences

The Screen-Well® Wnt pathway library v 2.0 is a focused collection of 71 compounds with defined and diverse Wnt pathway activity, including activators and inhibitors of Wnts, Dishevelled, GSK-3β and other Wnt pathway kinases, TCF/β-catenin, DKK, LRP, Axin, Porcupine, and more. Compounds are dissolved in DMSO at 10 mM or 1 mM and aliquoted into deep-well plates at 100 or 500 µl per well. A variety of structurally and mechanistically different compound classes are included. A useful tool for studying the roles of pro- and anti-Wnt pathway molecules in cells as well as for use in in vitro applications.

Supplier: Enzo Life Sciences

Human recombinant Caspase-14

Supplier: Enzo Life Sciences

Substrate for caspase-1 and -4

Supplier: Enzo Life Sciences

Inhibitor of caspase-1, -4 and -5

Supplier: Enzo Life Sciences

Caspase-2 inhibitor

Supplier: Enzo Life Sciences

Caspase-8 substrate

Supplier: Enzo Life Sciences

Cathepsin inhibitor

Supplier: Enzo Life Sciences

Cell permeable inhibitor of the 26S proteasome (MCP; multicatalytic proteinase complex) in HT4 cells. Causes accumulation of ubiquitinylated proteins in neuronal cells. Prevents the activation of NF-κB in response to TNF-α or okadaic acid through inhibition of IκBα degradation.