11723 Resultaten voor: "Enzo Life Sciences"

Supplier: Enzo Life Sciences

PPAR ligand.

Supplier: Enzo Life Sciences

Produced in E. coli.

Supplier: Enzo Life Sciences

DnaK possesses an autophosphorylation activity and a weak 5-nucleotidase activity, cleaving the 5 phosphate groups from both ribose and deoxyribose nucleotides. The role of DnaK in ATP-dependent protein-protein interactions has been extended to normal E. coli physiology, where, like eukaryotic Hsp70 homologs, it is thought to participate in the assembly/disassembly of protein complexes.

Supplier: Enzo Life Sciences

Heme Oxygenase-1 (HO-1) also known as Hsp32, is the inducible isoform of heme oxygenase that catalyzes the NADPH, oxygen, and cytochrome P450 reductase dependent oxidation of heme to carbon monoxide, ferrous iron and biliverdin which is rapidly reduced to bilirubin. These products of the HO reaction have important physiological effects: carbon monoxide is a potent vasodilator and has been implicated to be a physiological regulator of cGMP and vascular tone; biliverdin and its product bilirubin are potent antioxidants; "free" iron increases oxidative stress and regulates the expression of many mRNAs (e.g., DCT-1, ferritin and transferring receptor) by affecting the conformation of iron regulatory protein (IRP)-1 and its binding to iron regulatory elements (IREs) in the 5'- or 3'- UTRs of the mRNAs. To date, three identified heme oxygenase isoforms are part of the HO system that catalyze heme into biliverdin and carbon monoxide. These are inducible HO-1 or Hsp32, constitutive HO-2 that is abundant in the brain and testis, and HO-3 which is related to HO-2 but is the product of a different gene. The HO system is the rate-limiting step in heme degradation and HO activity decreases the levels of heme which is a well known potent catalyst of lipid peroxidation and oxygen radical formation.

Supplier: Enzo Life Sciences

Endogenous [1] ligand for the CB1 receptor (CB1: Ki=52nm; CB2: Ki=1930nm [2]) and TRPV1 (Ki=5.78µM [3,4]). Inhibits NF-κB activation through direct binding to IKKβ [5] and induces apoptosis independently of cannabinoid or vanilloid receptors [6]. Activates the MAP kinase (MAPK/ERK) signalling pathway [7].

Supplier: Enzo Life Sciences

PKA activator.

Supplier: Enzo Life Sciences

Unsaturated analog of endogenous sleep inducing lipid.

Supplier: Enzo Life Sciences

cGMP agonist.

Supplier: Enzo Life Sciences

Cannabinoid receptor ligand

Supplier: Enzo Life Sciences

Selective and potent inhibitor of the anandamide membrane transporter (AMT) (neuronal (C6 glioma cells): IC50=11µM; non-neuronal (rat RBL-2H3 cells): IC50=7.2µM) with negligible action at TRPV1 and weak action at CB1 receptor (CB1: Ki=5µM; CB2: Ki>5µM) and FAAH (IC50=3.7µM/ IC50>50µM (N18TG2 cell membranes).

Supplier: Enzo Life Sciences

Produced in Sf9 cells. Active, full length protein kinase C mu (PKCµ, protein kinase D, PKD) is fused at the N-terminus to a GST-tag.

Supplier: Enzo Life Sciences

Isolated from human plasma as prothrombin, and activated with Factor Xa, Factor Va, phospholipids, and calcium to yield a-thrombin.

Supplier: Enzo Life Sciences

Produced in E. coli.

Supplier: Enzo Life Sciences

Inhibitor of protein phosphatase.

Supplier: Enzo Life Sciences

β-1,4-Galactosyltransferase 1 (B4GALT1) is one of seven B4GALT genes. Human B4GALT1 encodes a type II membrane protein, which is ubiquitously expressed and involved in glycoconjugate biosynthesis. A soluble form (aa 78 to 398), derived from proteolytic cleavage, is a component of lactose synthase in milk that also contains α-lactalbumin. The amino acid sequence of human B4GALT1 is 88%, 87% and 71% identical to that of rat, mouse/canine and chicken.Defects in B4GALT1 are the cause of multisystem disorders present with a wide variety of clinical features, such as disorders of the nervous system development, psychomotor retardation, dysmorphic features, hypotonia, coagulation disorders, and immunodeficiency.

Supplier: Enzo Life Sciences

Inhibitory iODN oligodeoxynucleotide with phosphorothioate backbone. Potent sequence of an inhibitory ODN based on poly-G class I sequences targeting TLR9, but without additional effect on TLR7 and TLR8 signaling, for in vivo use in rodents (50-150µg per injection).

Supplier: Enzo Life Sciences

All members of the inhibitor of apoptosis proteins (IAP) family contain at least one, but usually three copies of baculovirus IAP repeat (BIR), a ~70-aa zinc binding domain, and upon overexpression suppress apoptosis. The BIR motif is capable of interacting with caspases and occluding their catalytic pockets. Certain IAPs also possess C-terminal RING domains. RING-containing proteins often act as E3 ubiquitin ligases and can catalyse the degradation of both, themselves and selected target proteins through ubiquitylation. So far, eight human IAPs have been identified: Apollon (Bruce), c-IAP1 (HIAP2; MIHB), c-IAP2 (HIAP1; MIHC), ILP-2 (Ts-IAP), Livin (ML-IAP; KIAP), NAIP, Survivin (TIAP) and XIAP (ILP-1; MIHA). c-IAP1 has been shown to inhibit specific caspases.

Supplier: Enzo Life Sciences

Anti-inflammatory and immunosuppressive

Supplier: Enzo Life Sciences

Anti-inflammatory, antioxidant and antimutagenic compound

Supplier: Enzo Life Sciences

iNOS inhibitor

Supplier: Enzo Life Sciences

HMG-CoA reductase inhibitor

Supplier: Enzo Life Sciences

Blocks methyl esterification of geranylgeranylated proteins

Supplier: Enzo Life Sciences

Dopamine receptor ligand.

Supplier: Enzo Life Sciences

Dopamine receptor ligand.

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Precursor to 1α,25-dihydroxyvitamin D₃

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Lipoxygenase inhibitor

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Antitumor agent.

Supplier: Enzo Life Sciences

RAIDD (RIP-associated ICH-1 homologous protein with a death domain) is an adaptor molecule that mediates the action of cysteine proteases involved in apoptosis. In human cell lines, the caspase-2 adaptor RAIDD interacts selectively with caspase-2 through its caspase recruitment domain (CARD) and leads to caspase-2-dependent death. RAIDD overexpression induced caspase-2, CARD- and caspase-9-dependent apoptosis of PC12 cells and sympathetic neurons. Apoptosis correlated with the formation of discrete perinuclear aggregates. Both death and aggregates required the expression of full-length RAIDD. It has been reported that activation of caspase-2 occurs in a complex that contains the death domain–containing protein PIDD, whose expression is induced by p53, and the adaptor protein RAIDD.

Supplier: Enzo Life Sciences

Recommended Applications: ELISA, WB

Species reactivity: Human

Supplier: Enzo Life Sciences

Cytochrome P450 inhibitor