11722 Results for: "ENZO LIFE SCIENCES"

Supplier: Enzo Life Sciences

The Carboxyfluorescein Multi-Caspase Activity Kit detects apoptosis through the covalent binding of a green fluorescent probe to active caspase enzymes in living cells.

Supplier: Enzo Life Sciences

PAF receptor activator.

Supplier: Enzo Life Sciences

Universal methylated DNA standard (human) with the included primers can be used in conjunction with Enzo blood and tissue methylation kit or the express methylation kits.

Supplier: Enzo Life Sciences

The Hsp90 family of heat shock proteins represents one of the most abundantly expressed and highly conserved families of cellular chaperones whose expression can be upregulated under conditions of cellular stress, and includes cytoplasmic (Hsp90-alpha/beta), ER (grp94), and mitochondrial (TRAP1) localized members.

Supplier: ENZO LIFE SCIENCES

This direct cAMP ELISA kit is the most sensitive colorimetric kit for intracellular cAMP quantification. For the quantitative determination of cAMP in cell lysates and tissue from any species. Cited sample types include cell culture supernatant and tissue culture.

Supplier: ENZO LIFE SCIENCES

Most sensitive (0,043pmol/m) and complete colorimetric kit for intra- and extracellular cGMP quantification.

Supplier: ENZO LIFE SCIENCES

For the quantitative determination of mouse TNF-α in culture supernatants and serum. Cited sample type includes tissue and plasma.

Supplier: ENZO LIFE SCIENCES

For the quantitative determination of 11-dehydro-TXB2 in culture supernatants and urine from any species. Cited samples include serum.

Supplier: ENZO LIFE SCIENCES

Fixation, (buffer)

Supplier: ENZO LIFE SCIENCES

The PGF2α high sensitivity EIA kit for the quantitative determination of PGF2α in culture supernatants, milk, plasma, serum, saliva, and urine from any species.

Supplier: ENZO LIFE SCIENCES

A complete kit for the labeling of antibodies, proteins, peptides, and nucleic acids with Acridinium NHS Ester.

Supplier: ENZO LIFE SCIENCES

For the measurement of acetyl-CoA dependent acetyltransferase activity in purified in vitro samples that do not contain reductants from any species.

Supplier: ENZO LIFE SCIENCES

TRAF proteins are multifunctional signal adaptors that are involved in the activation of the kinase cascades which activate c-Jun N-terminal kinase, p38 mitogen activated protein kinase, and the transcription factor NF-κB.

Supplier: ENZO LIFE SCIENCES

The caspases are a family of cysteine proteases that cleave after certain aspartate residues, and are primarily recognized as mediators of apoptosis. caspases are synthesized as inactive zymogens that can be cleaved to form active enzymes following the induction of apoptosis by stress or death receptors. Initiator caspases (e.g. caspase-8 and -10) are activated by dimerization of the zymogen on a dedicated adaptor protein. These activated initiator caspases in-turn cleave downstream effector or executioner caspases (e.g. caspase-3, -6, and -7) in a cascade-like manner, which cleave key cellular proteins that lead to the morphological changes associated with apoptotic cell death.

Supplier: ENZO LIFE SCIENCES

The RICK (Receptor-interacting serine/threonine protein kinase 2) protein, also known as RIP-like interacting CLARP kinase, and CARD-containing ICE associated kinase, contains an N-terminal kinase domain and a C-terminal CARD domain.

Supplier: ENZO LIFE SCIENCES

The chromatin non-histone high mobility group of proteins (HMG)-1 and -2 contain conserved domains known as HMG-boxes. Both HMG-1 and HMG-2 contain an N-terminal HMG box, a central HMG box and an acidic carboxy terminus.

Supplier: ENZO LIFE SCIENCES

Osteopontin (OPN) is an acidic extracellular matrix cell adhesion protein that is relatively abundant not only in bone matrix, plasma, urine, and milk, but is also found in malignant and atherogenic tissues. Phosphorylation, glycosylation and calcium modifications allow intact and fragmented Osteopontin to direct a variety of diverse responses including tissue remodeling, inflammation and cell survival. Plasma Osteopontin has been shown to provide prognostic information in breast, prostate, colon, and lung cancers as well as metastatic carcinomas. The notable presence of Osteopontin in a variety of tumors is strongly correlated to pathological stage, suggesting its critical role in tumor invasiveness, progression and metastasis. In addition, Osteopontin inhibits inducible nitric oxide synthase activity, thereby protecting tumor cells from NO-mediated macrophage cytotoxic attack. Osteopontin is found in atherosclerotic plaques and may drive a number of diabetic vascular pathologies.

Supplier: ENZO LIFE SCIENCES

The GST superfamily of enzymes play an important role in detoxification of xenobiotics by catalyzing the conjugation of many hydrophobic and electrophilic compounds with reduced glutathione. There are four main GST classes; alpha, mu, pi, and tau. GST-P is a member of the pi class of GSTs, and its expression is specifically increased in the early stages of rat hepatocarcinogenesis. Due to its high affinity for glutathione, GST is frequently utilized as an approximately 26 kDa fusion tag for the expression and purification of recombinant proteins.

Supplier: ENZO LIFE SCIENCES

Osteopontin (OPN) is an acidic extracellular matrix cell adhesion protein that is relatively abundant not only in bone matrix, plasma, urine, and milk, but is also found in malignant and atherogenic tissues. Phosphorylation, glycosylation and calcium modifications allow intact and fragmented Osteopontin to direct a variety of diverse responses including tissue remodeling, inflammation and cell survival. Plasma Osteopontin has been shown to provide prognostic information in breast, prostate, colon, and lung cancers as well as metastatic carcinomas. The notable presence of Osteopontin in a variety of tumors is strongly correlated to pathological stage, suggesting its critical role in tumor invasiveness, progression and metastasis. In addition, Osteopontin inhibits inducible nitric oxide synthase activity, thereby protecting tumor cells from NO-mediated macrophage cytotoxic attack. Osteopontin is found in atherosclerotic plaques and may drive a number of diabetic vascular pathologies.

Supplier: ENZO LIFE SCIENCES

TNF-alpha converting enzyme (TACE) is a membrane-bound metalloprotease-disintegrin in the family of mammalian ADAM (for a disintegrin and metalloprotease), and is responsible for the cleavage of membrane-bound precursor TNF-alpha to its mature, secreted form. TACE also processes other cell surface proteins, including TNF receptor, TGFalpha, the L-selectin adhesion molecule, and alpha-cleavage of amyloid protein precursor (APP).

Supplier: ENZO LIFE SCIENCES

The exotoxin produced by B. anthracis is composed of three proteins: a cell-receptor binding protein known as Protective Antigen (PA), and two enzymes, Edema Factor (EF) and Lethal Factor (LF). An 83 kDa form of PA binds to a cell surface receptor and, upon proteolytic activation to a 63 kDa fragment, heptamerizes to form a membrane channel that mediates the entry of three molecules of LF or EF into the cells. PA and LF form Lethal Toxin, which is the dominant virulence factor produced by B. Anthracis and is the major cause of death in infected animals.

Supplier: ENZO LIFE SCIENCES

The TLRs (Toll-like receptors) are a group of evolutionarily conserved pattern recognition molecules that play a key role in host defense during microbial infection by regulating both innate and adaptive immune responses. TLRs are type I transmembrane proteins with ectodomains containing interspersed leucine-rich repeat (LRR) motifs that are involved in the recognition of various microbial ligands.

Supplier: ENZO LIFE SCIENCES

Most comprehensive portfolio of heat shock protein (chaperone) products commercially available.

Supplier: ENZO LIFE SCIENCES

The caspases are a family of cysteine proteases that cleave after certain aspartate residues, and are primarily recognized as mediators of apoptosis. caspases are synthesized as inactive zymogens that can be cleaved to form active enzymes following the induction of apoptosis by stress or death receptors. Initiator caspases (e.g. caspase-8 and -10) are activated by dimerization of the zymogen on a dedicated adaptor protein. These activated initiator caspases in-turn cleave downstream effector or executioner caspases (e.g. caspase-3, -6, and -7) in a cascade-like manner, which cleave key cellular proteins that lead to the morphological changes associated with apoptotic cell death.

Supplier: ENZO LIFE SCIENCES

Bax is an appromimately 22 kDa pro-apoptotic protein belonging to the Bcl-2 family of proteins, which are characterised by the presence of atleast one Bcl-2 homology (BH) domains.

Supplier: ENZO LIFE SCIENCES

Antigen retrieval reagent is used to recover antigens masked by fixation in cross linking fixatives such as formalin.

Supplier: ENZO LIFE SCIENCES

Osteoprotegerin (OPG) is a secreted glycoprotein belonging to the TNF receptor (TNF-R) superfamily that functions as a decoy receptor for RANK-Ligand (RANKL/OPGL). Unlike other TNF-Rs, OPG lacks a membrane-anchoring hydrophobic domain and lacks any apparent cell-associated signaling capability. OPG secreted by osteoblasts competes with RANK (expressed on osteoblast precursors) for binding to RANKL, blocking osteoclastogenesis and increasing bone density.

Supplier: ENZO LIFE SCIENCES

Anti-EIF2 alpha Rabbit Polyclonal Antibody

Supplier: ENZO LIFE SCIENCES

Acetylation and methylation of lysine are important post-translational modifications that regulate numerous protein-protein and protein-DNA interactions. Lysine acetylation and methylation involves the transfer of acetylCoA, or one or more methyl groups, to the e-amino group of lysine by modifying enzymes and cofactors. Histones and transcription factors are the primary targets of lysine acetylation and methylation, with either modification capable of inducing gene silencing or expression due to differential regulation of cofactors. For example, varying degrees of mono-, di-, and tri-methylation or acetylation of histone H3 at lysine residue 9 are known to demark distinct chromatin regions during various states of gene activation (methylation) or repression (acetylation).

Supplier: ENZO LIFE SCIENCES

Researchers cloned DJ-1 protein, consisting of 189 amino acids, from a HeLa cell cDNA library as a oncogene which weakly transformed NIH3T3 cells. Cotransfection with ras or c-myc enhances transformation by DJ-11. DJ-1 expression is induced by growth signals, and it is translocated from the cytoplasm to the nucleus during the S phase without the presence of any nuclear localization signals. In addition to its potential involvement in ras-mediated signal transduction pathways, DJ-1 is known to regulate transcription of androgen-responsive genes, and is sensitive to oxidative stress. DJ-1 is ubiquitously expressed in various human tissues including the brain, with high expression in astrocytes of the frontal cortex and substantia nigra. Homozygous mutations in the DJ-1 gene have been shown to cause early-onset autosomal recessive Parkinson’s disease.