A potent, cell permeable inhibitor of p38 MAP kinase (IC50=44nM for recombinant purified human p38α). Inhibits IL-1 and TNF-α production in LPS-stimulated human peripheral blood monocytes (IC50=120nM and 350nM, respectively). Reported to protect against mild excitotoxic neuronal injury caused by NMDA and provides substantial protection against cell death induced by either oxygen glucose deprivation (OGD) or magnesium deprivation in cultured neurons. Also, reduces myocardial reperfusion injury via inhibition of endothelial adhesion molecule expression and blockade of polymorphonuclear (PMN) accumulation.

Expand 3 Items

3-(4-Hydroxybenzylidenyl)indolin-2-one (synthetic) ≥98%

Supplier: Enzo Life Sciences

Selective receptor tyrosine kinase (RTK) inhibitor. Inhibits FLK-1 RTK (IC50 ~3µM). Consists predominantly of the E-isomer, contains ~10% of the Z-isomer.

Expand 1 Items

SH-5

Supplier: Enzo Life Sciences

Akt inhibitor

Expand 2 Items

Pioglitazone ≥97% (by HPLC)

Supplier: Enzo Life Sciences

PPARgamma activator.

Expand 2 Items

Anti-SNAP25 Rabbit Polyclonal Antibody

Supplier: Enzo Life Sciences

SNAP-25 (synaptosomal associated protein of 25kDa) is a soluble protein of 25kDa which plays a key role in vesicle membrane fusion events with the plasma membrane. This protein was originally discovered to be enriched in subsets of neurons in the brain and displays a presynaptic pattern of expression. The membrane proteins SNAP-25, synaptobrevin, and syntaxin form the core of a ubiquitous membrane fusion machine that interacts with the soluble proteins NSF and α-SNAP. Functional interactions have been demonstrated to exist between SNAP-25, syntaxin, and the synaptic protein interaction site on voltage-sensitive L- and N-type Ca2+ channels. SNAP-25 has been shown to be required for synaptic vesicle fusion with the plasma membrane during release of NGF. Regulated exocytosis of cortical granule secretion in fertilized eggs and membrane fusion events in neurons and endocrine cells is mediated by SNAP-25 in a Ca2+-dependent mechanism. SNAP-25 protein levels have been shown to be elevated in prolactinoma and GH/PRL tumor cells while reduced SNAP-25 protein expression has been observed between schizophrenic and normal hippocampal cells. Altered patterns of SNAP-25 expression have also been observed in the inferior temporal cortex and prefrontal association cortex between normal brains and brains from individuals affected with schizophrenia. SNAP-25 accumulation due to cytoskeletal dysfunction is also observed in the swollen axons of the white matter of individuals with severe Alzheimer's dementia.

Expand 2 Items

Human recombinant CD40:Fc

Supplier: Enzo Life Sciences

Produced in HEK 293 cells. The cysteine-rich region (aa 21-193) of human CD40 is fused to the Fc portion of human IgG1.

Expand 2 Items

Human recombinant TNF alpha (soluble) (from E. coli)

Supplier: Enzo Life Sciences

Produced in E. coli. The extracellular domain of human TNF-α (tumor necrosis factor-α) (aa 85-223) is fused at the N-terminus to a linker peptide (8 aa) and a FLAG®-tag.