11722 Results for: "ENZO LIFE SCIENCES"

Supplier: Enzo Life Sciences

Produced in Sf9 cells.

Supplier: Enzo Life Sciences

Host: Rat, Isotype: IgG1

Supplier: Enzo Life Sciences

Benzamide

Supplier: Enzo Life Sciences

PTP inhibitor, PTEN Inhibitor

Supplier: Enzo Life Sciences

Inhibitor of ACE and leukotriene hydrolase

Supplier: Enzo Life Sciences

Specific inhibitor of insulin-like growth factor-1 (IGF-1) and insulin receptor kinases. Induces apoptosis by downregulation of the expression of phospho-Akt1 and Bcl-2. Also increases Bax, p53 and p21 expression.

Supplier: Enzo Life Sciences

Water-soluble, potent inhibitor of poly(ADP-ribose) polymerase-1 (PARP-1).

Supplier: Enzo Life Sciences

p38 inhibitor

Supplier: Enzo Life Sciences

Cell permeable derivative of vitamin E. Antioxidant. Inhibits peroxynitrite mediated tyrosine nitration and mitochondrial proton permeability. Prevents lipid peroxidation, cytotoxicity and apoptosis induced by cytochrome P450 2E1 in HEP G2 cells.

Supplier: Enzo Life Sciences

Substrate for caspase-1 and -4

Supplier: Enzo Life Sciences

Caspase-8 substrate

Supplier: Enzo Life Sciences

Inhibitor of caspase-1, -4 and -5

Supplier: Enzo Life Sciences

Caspase and granzyme inhibitor

Supplier: Enzo Life Sciences

3-Bromo-7-nitro-1H-indazole

Supplier: Enzo Life Sciences

Caspase-2 inhibitor

Supplier: Enzo Life Sciences

Cell permeable inhibitor of the 26S proteasome (MCP; multicatalytic proteinase complex) in HT4 cells. Causes accumulation of ubiquitinylated proteins in neuronal cells. Prevents the activation of NF-κB in response to TNF-α or okadaic acid through inhibition of IκBα degradation.

Supplier: Enzo Life Sciences

Fluorogenic substrate for Alzheimer's Disease amyloid A4-generating enzymes and for the proteasome.

Supplier: Enzo Life Sciences

Colorimetric caspase substrate for caspase-1, -4, -5 and -14.

Supplier: Enzo Life Sciences

Fluorescent probe for NO detection. Cell permeable.

Supplier: Enzo Life Sciences

Fluorescent probe for hROS detection.

Supplier: Enzo Life Sciences

Fluorescent probe for hROS detection.

Supplier: Enzo Life Sciences

Host: Mouse, Isotype: IgG1

Supplier: Enzo Life Sciences

Host: Mouse, Isotype: IgG1

Supplier: Enzo Life Sciences

Host: Rat, Isotype: IgG2a

Supplier: Enzo Life Sciences

Bile Salts
Bile salts are important physiological agents that serve a number of functions, including absorption, solubilization, transport and secretion of lipids. In the liver, they participate in the generation of bile flow and the secretion of cholesterol and phospholipids, such as phosphatidylcholine. When released into the intestine, they facilitate the uptake of cholesterol, fat-soluble vitamins and other lipids. Moreover, the biosynthesis of bile acids from cholesterol is the most significant pathway for the elimination of cholesterol from the body. However, because of their detergent properties, bile acids are inherently cytotoxic and disruptions in their normal transport or secretion can result in a variety of pathophysiological conditions.

BSEP
Bile formation is an important function of the liver. It is mediated by hepatocytes which generate bile flow within the bile canaliculi by continuous vectorial secretion of bile salts and other solutes across their canalicular (apical) membrane. Bile secretion is mediated by several ATP-binding cassette (ABC) transporters located in the canalicular membrane of hepatocytes. Among these ABC transporters, the bile salt export pump (BSEP or ABCB11) represents the primary, if not sole transport system for the canalicular excretion of bile salts. Bile secretory failure results in cholestasis and progressive familial intrahepatic cholestasis (PFIC) in infancy represents a group of inherited cholestatic diseases that are classified into three subtypes. One of these subtypes, PFIC II, is associated with mutations in the BSEP gene. PFIC patients with mutations in the BSEP gene have normal γ-glutamyltransferase activity, low concentrations of bile salts in bile, and an absence of bile duct proliferation. Additionally, human obesity is associated with altered cholesterol homeostasis including increased production and turnover, as well as secretion of excess cholesterol from the liver into bile.

BSEP is a multifunctional polypeptide with two homologous halves, each containing a hydrophobic membrane-ancoring domain and an ATP-binding cassette (ABC) domain. The membrane-anchoring domain is composed of six helixes buried in the lipid bilayer of the plasma membrane and the ATP binding ABCs are exposed to the cytosol. The membrane-anchoring domain helixes are thought to form channels spanning the plasma membrane.

Supplier: Enzo Life Sciences

Host: Rat, Isotype: IgG2a

Supplier: Enzo Life Sciences

Anti-Enhancer for Ligands Monoclonal Antibody

Supplier: Enzo Life Sciences

The ryanodine receptor (RyR) is the channel responsible for the release of calcium from the sarcoplasmic reticulum (SR) in muscle cells and also plays a role in calcium regulation in non-muscle cells. The RyR exists as a homotetramer and is predicted to have a short cytoplasmic C-terminus and 4-10 transmembrane domains; the remainder of the protein, termed the "foot" region is located in the cytoplasm between the T-tubule and the SR. The mammalian RyR is the product of three different genes: RyR-1, which is expressed predominantly in skeletal muscle and areas of the brain, RyR-2, which is expressed predominantly in the heart muscle but also found in the stomach, endothelial cells and diffuse areas of the brain, and RyR-3 which is found in smooth muscle and the brain (striatum, thalamus and hippocampus).

Supplier: Enzo Life Sciences

Host: Mouse, Isotype: IgG2a

Supplier: Enzo Life Sciences

Cathepsin inhibitor