Supplier: Enzo Life Sciences

Phosphodiesterase PDE II inhibitor, IC50=0.8 µM. Also inhibits adenosine deaminase, Ki=4 nM.

Supplier: Enzo Life Sciences

Host: Rabbit

Supplier: Enzo Life Sciences

Host: Rabbit

Supplier: Enzo Life Sciences

ACE1 (angiotensin converting enzyme-1, ACE) is a key regulator of blood pressure.

Supplier: Enzo Life Sciences

Produced in E. coli.

Supplier: Enzo Life Sciences

Produced in HEK 293 cells.

Supplier: Enzo Life Sciences

Produced in HEK 293 cells.

Supplier: Enzo Life Sciences

Produced in E. coli.

Supplier: Enzo Life Sciences

Produced in E. coli.

Supplier: Enzo Life Sciences

Glycoprotein-340 belongs to the scavenger receptor superfamily which functions as a putative SP-D receptor. Gp-340 binds SP-D in a calcium dependent manner through a protein-protein interaction. Like SP-D, gp-340 is mainly found in lung tissue, and immunohistochemistry reveals high expression in alveolar macrophages. An identical protein is present in saliva (salivary agglutinin), and both forms are encoded by the gene DMBT1.

Supplier: Enzo Life Sciences

Surfactant protein A (SP-A) is synthesized and secreted by lung epithelial cells. It belongs to group III of the family of C-type lectins, members of which possess an overall structure consisting of multiple globular head regions linked by triple-helical, collagen-like, strands. This group also includes SP-D, and the serum proteins mannan-binding protein, conglutinin, and collectin-43, all of which bind to the C1q receptor found on a wide variety of cells. Both SP-D and SP-A enhance oxygen radical production by alveolar macrophages. The serum concentration is 45 ng/mL in healthy individuals.

Supplier: Enzo Life Sciences

Anti-Complement C5a Mouse Monoclonal Antibody [clone: C17/5]

Supplier: Enzo Life Sciences

Vitronectin is a plasma glycoprotein that circulates in the blood as a mixture of both 75kDa and 65kDa forms. Vitronectin is a major cell adhesive glycoprotein, and a common component of extracellular matrix and plasma. It competes effectively with other plasma proteins, and often participates in cell attachment, regulation of blood coagulation and immune responses. It has similar tissue distribution to fibronectin, which is recognized by its integrin receptor.

Supplier: Enzo Life Sciences

Complement factor C9 is a 71kDa single-chain ellipsoid a-globular molecule of 558 amino acids including a leader sequence of 20 amino acids. C9 binds the C5b8 complex on membranes and has the unique function of forming tubular structures containing between 12 and 18 monomers, closely resembling the membrane attack complex (MAC). The primary site of synthesis is hepatocytes; secondary sites are monocytes, fibroblasts and glial cells. The normal level of C9 in plasma is 60 µg/ml, and the level is upregulated from hepatocytes by IFN-γ.

Supplier: Enzo Life Sciences

L-Ficolin (Ficolin-2) is an innate immunity pattern recognition molecule found in human serum. L-Ficolin binds to distinct pathogen-associated molecular patterns (PAMP) such as carbohydrates (GlcNAc), lipoteichoic acid and acetylated groups, thereby facilitating phagocytosis and activation of complement through the lectin route using the same serine proteases as mannose-binding lectin (MBL) named MASP (MBL-associated serine protease).

Supplier: Enzo Life Sciences

A Real-time Mitochondrial membrane Potential Assay with Superior Sensitivity. Suitable for high-throughput applications.

Supplier: Enzo Life Sciences

Gold 525 dUTP (lyophilised)

Supplier: Enzo Life Sciences

Recommended Applications: ICC, IHC, IP, WB, Immunoelectron microscopy

Supplier: Enzo Life Sciences

Analog to ampicillin. Inhibits bacterial cell-wall synthesis (peptidoglycan cross-linking) by inactivating transpeptidases on the inner surface of the bacterial cell membrane. Effective against Gram-positive and Gram-negative bacteria and Pseudomonas.

Supplier: Enzo Life Sciences

Blocks methyl esterification of geranylgeranylated proteins

Supplier: Enzo Life Sciences

The Screen-Well® neurotransmitter library contains 681 CNS receptor ligands in a 96-well format. Ideal for screening or identifying recombinant orphan G protein-coupled receptors, target validation, secondary screening, validating new assays, and for routine pharmacological applications.

Supplier: Enzo Life Sciences

UBA6 (ubiquitin-like modifier activating enzyme-6, also known as UbE1L2) is a novel ubiquitin activating enzyme that is also capable of activating the ubiquitin-like protein FAT10 (human leukocyte antigen F-associated transcript 10), which, similarly to ubiquitin, may serve as a signal for proteasomal degradation. Only one UBA6 specific E2 conjugating enzyme, known as Use1 (Uba6-specific E2 enzyme 1) or UbE2Z, which is capable of accepting activated FAT10, has been identified to date.

Supplier: Enzo Life Sciences

The tumor suppressor CYLD is a deubiquitinylating enzyme (DUB) that antagonises NF-κB and JNK signaling by disassembly of Lys63-linked ubiquitin chains synthesised in response to cytokine stimulation. The DUB activity of CYLD is mediated by its C-terminal ubiquitin specific protease (USP) domain, pathogenic truncations and mutations of which are associated with the hypertrophic skin tumor cylindromatosis through disruption of the USP domain and subsequent loss of CYLD catalytic activity.

Supplier: Enzo Life Sciences

MYSM1 (Myb-like, SWIRM and MPN domain-containing protein 1) is a JAMM domain containing zinc metalloprotease that acts a deubiquitinylating enzyme specific for mono-ubiquitinylated histone H2A. MYSM1 acts by coordinating histone acetylation and deubiquitination, and destabilizing the association of linker histone H1 with nucleosomes. In addition, MYSM1 participates in transcriptional regulation events in androgen receptor-dependent gene activation. Levels of monoubiquitinylated H2A are dramatically decreased in prostate tumors, suggesting MYSM1 expression may serve as a cancer marker.

Supplier: Enzo Life Sciences

The JAMM domain containing zinc metalloprotease AMSH (Associated Molecule with the SH3-domain of STAM) acts as a deubiquitinylating enzyme during the sorting process to regulate receptor trafficking by specifically cleaving Lys63-linked polyubiquitin chains from internalized receptors. The amino-terminal half of AMSH proteins interacts with clathrin and ESCRT proteins on the endosome, whereas the C-terminal half is engaged in Lys63-linkage-specific deubiquitination. AMSH mediated cleavage of K63-linked ubiquitin chains is enhanced in the presence of its binding partner STAM.

Supplier: Enzo Life Sciences

Recommended Applications: IP, WB

Species reactivity: Human

Supplier: Enzo Life Sciences

Recommended Applications: ELISA, IP, WB

Species reactivity: Human, Mouse

Supplier: Enzo Life Sciences

Recommended Applications: ELISA, ICC, IHC (FS), IHC (PS), WB

Species reactivity: Human

Supplier: Enzo Life Sciences

Inhibits mitochondrial ATPases (F₁F₀). Stimulates lysosome acidification due to shunting of membrane potential. Induces apoptosis in a variety of cell types. Induces autophagy in the IPLB-LdFB insect cell line.

Supplier: Enzo Life Sciences

MPTP activator