11723 Results for: "ENZO LIFE SCIENCES"

Adenosine is an endogenous nucleoside generated locally in tissues under conditions of hypoxia, ischemia, or inflammation. It modulates a variety of physiological functions in many tissues including brain and heart. It exerts its action via four specific adenosine receptors (also named P1 purinergic receptors): A1 Adenosine Receptor (A1AR), A2A Adenosine Receptor (A2AAR), A2B Adenosine Receptor (A2BAR), and A3 Adenosine Receptor (A3AR). All are integral membrane proteins and members of the G Protein-Coupled Receptor superfamily. The various adenosine receptors can be distinguished on the basis of their differential selectivity for adenosine analogs. A1AR is widely distributed and has been well characterized. High expression of A1AR is found in brain, dorsal horn of the spinal cord, adrenal gland, and atria, and other tissues including adipose, colon, and kidney. A1AR is the most prominent adenosine receptor in adipocytes and has become a target for research on obesity. A possible role in cell proliferation and carcinogenesis has also been suggested for A1AR.

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Zaprinast ≥98% (by TLC)

Supplier: Enzo Life Sciences

PDE inhibitor

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12-Deoxyphorbol-13-phenylacetate-20-acetate ≥99% (by HPLC, TLC)

Supplier: Enzo Life Sciences

dPPA is a selective activator of PKCß. It is at least 100-fold more potent for the ß isozymes than the α, γ, δ or ε isozymes but activates the ß1 isozyme to only 60% of maximal activity. Mimics the effect of TNF on endothelial cells but does not translocate PKC.

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Anti-ADORA3 Rabbit Polyclonal Antibody

Supplier: Enzo Life Sciences

Adenosine is an endogenous nucleoside generated locally in tissues under conditions of hypoxia, ischemia, or inflammation. It modulates a variety of physiological functions in many tissues including brain and heart. It exerts its action via four specific adenosine receptors (also named P1 purinergic receptors): A1 Adenosine Receptor (A1AR), A2A Adenosine Receptor (A2AAR), A2B Adenosine Receptor (A2BAR), and A3 Adenosine Receptor (A3AR). All are integral membrane proteins and members of the G Protein-Coupled Receptor superfamily. The various adenosine receptors can be distinguished on the basis of their differential selectivity for adenosine analogs. Expression of A3AR has been reported in brain, kidney, liver, and heart. It plays a role in modulation of cerebral ischemia, asthma, and cell growth. In addition, it may have a cardioprotective role for A3AR. Expression of A3AR was reported to be elevated in cancerous tissues as well as in auto-immune inflammatory diseases.

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Anti-Proteinase-Activated Receptor-2 Rabbit Polyclonal Antibody

Supplier: Enzo Life Sciences

PAR-2 belongs to a four member family of G protein-coupled receptors (PAR-1 to -4) that are activated as a result of proteolytic cleavage by certain serine proteases, hence their name. In this modality of activation, a specific proteinase cleaves the PAR receptor within a defined sequence in its extracellular N-terminal domain. This cleavage results in the creation of a new N-terminal sequence (tethered ligand), which subsequently binds to a site in the second extracellular loop of the same receptor. This binding results in the coupling of the receptor to G proteins and in the activation of several signal transduction pathways1-3 Different PARs are activated by different proteinases. Hence, PAR-1 is activated by thrombin as are PAR-3 and PAR-4, while PAR-2 is activated by trypsin1-3. PAR-2 can be also cleaved and activated by other proteinases such as tryptase, membrane-type serine protease 1, and proteinase 31-3 PAR-2-mediated intracellular signaling has not been clearly elucidated, but activators of PAR-2 induce generation of IP3 and mobilization of intracellular Ca2+. Activation of the ERK1/2 and NF-kB intracellular pathways following PAR-2 activation has been also described1-3 Tissue distribution of PAR-2 is wide with the highest expression levels found in pancreas, small intestine, liver and kidney. In addition, PAR-2 expression was observed in dorsal root ganglion neurons, smooth muscle cells and endothelial cells. The physiological role of PAR-2 is not yet clearly understood, however studies using PAR-2 knockout mice have suggested roles in the cardiovascular, pulmonary and gastrointestinal systems. Several studies suggest that PAR-2 plays a central role in inflammatory diseases and nociceptive pain transduction; hence PAR-2 blockers have been proposed to be useful in the therapeutic control of inflammation and pain1-3.

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Anti-A2AB Rabbit Polyclonal Antibody

Supplier: Enzo Life Sciences

Adenosine is an endogenous nucleoside generated locally in tissues under conditions of hypoxia, ischemia, or inflammation. It modulates a variety of physiological functions in many tissues including brain and heart. It exerts its action via four specific adenosine receptors (also named P1 purinergic receptors): A1 Adenosine Receptor (A1AR), A2A Adenosine Receptor (A2AAR), A2B Adenosine Receptor (A2BAR), and A3 Adenosine Receptor (A3AR). All are integral membrane proteins and members of the G Protein-Coupled Receptor superfamily. The various adenosine receptors can be distinguished on the basis of their differential selectivity for adenosine analogs. The A2 Adenosine receptor subtype was subdivided according to affinity for adenosine; A2AAR has high affinity and A2BAR has low affinity for adenosine. A2BAR is expressed in mast cells, neutrophils, monocytes, macrophages, dendritic cells, T cells, bronchial epithelium, intestinal epithelium, smooth muscle, brain, and other cells. In intestinal epithelia, A2BAR was found to be the major adenosine receptor subtype expressed and is thought to be involved in diarrheal diseases. It is also believed to be involved in the pathogenesis of chronic airway inflammatory diseases. Antagonists of A2BAR may be effective for the treatment of inflammatory gastrointestinal tract disorders4 as well as asthma and chronic obstructive pulmonary disease.

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Leukotriene C4 ≥95% (by HPLC)

Supplier: Enzo Life Sciences

Prostanoid receptor ligand.

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Human recombinant Casein kinase II (from E. coli)

Supplier: Enzo Life Sciences

Produced in E. coli. Consists of 44 kDa alpha catalytic and 26 kDa & szlig; regulatory subunits as an alpha2& szlig;2 tetramer.

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BKM120 ≥97% (by HPLC)

Supplier: Enzo Life Sciences

Potent inhibitor of PI3Kα

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Motesanib ≥99% (by HPLC)

Supplier: Enzo Life Sciences

Cell-permeable inhibitor of VEGF receptors, PDGFR, and Kit receptor.

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AGK7 ≥99% (by HPLC)

Supplier: Enzo Life Sciences

Selectively inhibits sirtuin 3 over sirtuins 1 and 2.

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Bisindolylmaleimide I hydrochloride ≥99% (by HPLC)

Supplier: Enzo Life Sciences

Anti-inflammatory agent and protein kinase C inhibitor.

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Glycogen phosphorylase inhibitor ≥99% (by HPLC)

Supplier: Enzo Life Sciences

Cell-permeable, potent and AMP-competitive inhibitor of glycogen phosphorylase.

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Anti-ADRM1 Rabbit Polyclonal Antibody

Supplier: Enzo Life Sciences

Recommended Applications: ELISA, ICC, IHC (FS), IHC (PS), WB

Species reactivity: Human

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Anti-IgG Rabbit Polyclonal Antibody (DyLight™ 488)

Supplier: Enzo Life Sciences

Recommended Applications: Flow Cytometry

Species reactivity: Species independent

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Cabozantinib ≥99% (by HPLC)

Supplier: Enzo Life Sciences

Potent inhibitor of VEGFR-2, MET, Kit and FLT3-ITD

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BMS-5 ≥98% (by HPLC)

Supplier: Enzo Life Sciences

Inhibitor of LIMK1 and LIMK2

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Leukotriene B4 ≥99% (by HPLC)

Supplier: Enzo Life Sciences

Prostanoid receptor ligand.

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Epoprosterol sodium ≥98% (by TLC)

Supplier: Enzo Life Sciences

Biosynthesis in endothelial cells. Induces vasodilation, inhibits platelet aggregation by receptor-mediated stimulation of adenylate cyclase. Cytoprotective. Fibrinolytic. Half-life under physiological conditions is 2 minutes.