11722 Results for: "ENZO LIFE SCIENCES"

Red 650 [Cyanine-5E] dUTP is a cyanine-5 derivative with enhanced spectral properties. This nucleotide analog can replace TTP in reactions in which it serves as a substrate for E.coli DNA polymerase (holoenzyme and Klenow fragment), T4 and Taq DNA polymerases, reverse transcriptase (from AMV and M-MuLV) and terminal transferase. Fluorescently labeled probes can be prepared with this fluorescent nucleotide by a variety of methods including nick translation, cDNA labelling and 3'-end labelling.

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Epoxomicin ≥95% (by HPLC)

Supplier: Enzo Life Sciences

Key inhibitor for use in proteasome research.

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Anti-Glutamate decarboxylase 1, Glutamate decarboxylase 2 Mouse Monoclonal Antibody [clone: 9A6]

Supplier: Enzo Life Sciences

GAD, glutamic acid decarboxylase, is an integral membrane protein that catalyzes the formation of gamma-aminobutyric acid (GABA), which is an inhibitory neurotransmitter. The biological functions of GAD and GABA extend beyond regulation of neurotransmission to include effects on the immune system and modulation of cell proliferation, protein synthesis, and metabolism.

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LY2183240 ≥98% (by TLC)

Supplier: Enzo Life Sciences

Anandamide transporter inhibitor

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Anti-Surfactant Protein A Mouse Monoclonal Antibody

Supplier: Enzo Life Sciences

Surfactant protein A (SP-A) is synthesized and secreted by lung epithelial cells. It belongs to group III of the family of C-type lectins, members of which possess an overall structure consisting of multiple globular head regions linked by triple-helical, collagen-like, strands. This group also includes SP-D, and the serum proteins mannan-binding protein, conglutinin, and collectin-43, all of which bind to the C1q receptor found on a wide variety of cells. Both SP-D and SP-A enhance oxygen radical production by alveolar macrophages. The serum concentration is 45 ng/mL in healthy individuals.

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Anti-H-Ficolin Mouse Monoclonal Antibody [clone: FCN334]

Supplier: Enzo Life Sciences

Anti-H-Ficolin Mouse Monoclonal Antibody [clone: FCN334]

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SQ 22536 ≥99% (by TLC)

Supplier: Enzo Life Sciences

Adenylate cyclase inhibitor

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8-Bromo-cAMP sodium salt ≥98% (by HPLC)

Supplier: Enzo Life Sciences

PKA activator.

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Ciprofloxacin hydrochloride monohydrate ≥98% (by HPLC)

Supplier: Enzo Life Sciences

Fluoroquinolone antibacterial agent. Inhibits bacterial DNA gyrase (topoisomerase). Inhibits cell division and causes double-strand breaks in the bacterial chromosome. Broad-spectrum antibiotic effective against Gram-positive, Gram-negative and anaerobic bacteria.

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Ampicillin sodium salt ≥93%

Supplier: Enzo Life Sciences

β-Lactam antibiotic. Inhibits bacterial cell-wall synthesis (peptidoglycan cross-linking). Inactivates transpeptidases on the inner surface of the bacterial cell membrane. Effective against Gram-negative and Gram-positive bacteria.

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Nuclear receptor ligand library plates, SCREEN-WELL®

Supplier: Enzo Life Sciences

The SCREEN-WELL® Nuclear Receptor Ligand Library contains 74 compounds with defined, putative and potential activity at nuclear receptors.

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Anti-CRYAB Rabbit Polyclonal Antibody

Supplier: Enzo Life Sciences

α-Crystallins composed of αA (~19 kDa) and αB (~19.2 kDa) subunits, are major water-soluble proteins accounting for almost 50% of total protein in the mammalian transparent eye lens and they are also found in a variety of other tissues. Alpha-crystallins are also referred to as small heat shock proteins, since they are induced by increased temperature in a variety of organisms. The α-crystallins have sequence homology as well as structural and functional similarities with the small Hsp’s such as Hsp25/27. Most α-crystallins have four common structural and functional features: (i) molecular weight between 12 and 43kDa; (ii) the formation of large oligomeric complexes composed of αA-crystallin, αB-crystallin and Hsp25/27; (iii) the moderately conserved α-crystallin domain in the central region of the protein; and (iv) molecular chaperone activity. The α-crystallin domain comprises approximately 90 residues, is bounded by variable N-terminal and C-terminal extensions and is involved in oligomer assembly. Oligomers can reach 800 kDa or more and are dynamic, exhibiting subunit exchanges and organizational plasticity, possibly leading to functional diversity. Phosphorylation of serine residues occurs during development and in response to stress, and usually decreases oligomer size. Chaperone activity requires, and is modulated by, oligomerization and is limited to binding unfolded intermediates to prevent irreversible aggregation. Although productive release and refolding of denatured proteins requires close cooperation with other chaperones. Other proposed functions include a role in membrane stabilization and modulation of intermediate filament organization during physiological stress and neurodegenerative disease. Alpha B Crystallin is phosphorylated on serine 45 by ERK1/2 and serine 59 by MAPKAPK-2. When mono-phosphoylated αB-crystallin is isolated it contains only αB-crystallin phosphorylated at serine 19.

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Anti-SOD2 Rabbit Polyclonal Antibody

Supplier: Enzo Life Sciences

SOD (Superoxide dismutase) is responsible for the elimination of cytotoxic active oxygen by catalyzing the dismutation of the superoxide radical to oxygen and hydrogen peroxide. There are three SOD isoenzymes in mammalian cells, they are: EC SOD (extracellular SOD), Cu/Zn SOD (copper and zinc-containing SOD) and Mn SOD (manganese-containing SOD).

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Anti-ERP57 Rabbit Polyclonal Antibody

Supplier: Enzo Life Sciences

ERp57 (also known as Grp58), a member of the Thioredoxin superfamily, is an ER protein with disulfide isomerase activity. It has been shown to increase after oncogenic transformation and to be a component of the MHC Class I peptide-loading complex.

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Anti-CTRP3 Rabbit Polyclonal Antibody

Supplier: Enzo Life Sciences

The C1q/tumor necrosis factor-α-related proteins (CTRPs) are a highly conserved family of adipokines that are functional paralogs of adiponectin. These proteins (CTRP1-7) are thought to act mainly on liver and muscle tissue to control glucose and lipid metabolism. Unlike adiponectin, which is expressed exclusively by differentiated adipocytes, the CTRPs are expressed in a wide variety of tissues.

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Anti-CASP2 Mouse Monoclonal Antibody [clone: 38443]

Supplier: Enzo Life Sciences

The caspases are a family of cysteine proteases that cleave after certain aspartate residues, and are primarily recognized as mediators of apoptosis. caspases are synthesized as inactive zymogens that can be cleaved to form active enzymes following the induction of apoptosis by stress or death receptors. Initiator caspases (e.g. caspase-8 and -10) are activated by dimerization of the zymogen on a dedicated adaptor protein. These activated initiator caspases in-turn cleave downstream effector or executioner caspases (e.g. caspase-3, -6, and -7) in a cascade-like manner, which cleave key cellular proteins that lead to the morphological changes associated with apoptotic cell death.