113035 Results for: "Cryogene+vriezers&pageNo=10&view=list"
HPL Flat Base, 800mm wide 1 * 1 items
Supplier: BIGNEAT
HPL Flat Base, 800mm wide 1 * 1 items
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Human Recombinant PDGF-AB
Supplier: STEMCELL Technologies
Platelet-derived growth factor (PDGF) is a dimeric glycoprotein consisting of two disulfide bridge-stabilized polypeptide chains, A and B, which are assembled as heterodimers (PDGF-AB) or homodimers (PDGF-AA and PDGF-BB) (Fretto et al.; Westermark and Heldin). PDGF signals through the receptor tyrosine kinases PDGFRalpha and PDGFRbeta. It has been shown that PDGF-induced migration involves signaling pathways involving MEK/ERK, EGFR, Src, and PI3K/AKT (Kim et al.). PDGF is a potent mitogen for cells of mesenchymal origin- like fibroblasts, glial cells, and vascular smooth muscle cells. PDGF has been implicated in pathogenesis of atherosclerosis, glomerulonephritis, cancer, and in the contraction of vascular smooth muscle cells of rat aortic tissues (Fretto et al.; Sachinidis et al.). It has been shown that PDGF-AB together with 5-Azacytidine (Catalog #72012), induces the conversion of mature bone and fat cells into tissue-regenerative multipotent stem cells (Chandrakanthan et al.).
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Ultra-Plex™ 1-Step ToughMix® (4X)
Supplier: Quantabio
Ultra-Plex™ 1-Step ToughMix® is a ready-to-use, 4X-concentrated master mix for reverse transcription quantitative PCR (RT-qPCR) of RNA templates using hybridisation probe detection chemistries such as TaqMan® 5’-hydrolysis probes on Real-Time PCR systems that utilise ROX passive reference with 490 nM excitation. First-strand cDNA synthesis and PCR amplification are carried out in the same tube without opening between procedures. It is ideal for highly sensitive quantification of RNA viruses or low abundance RNA targets in uni- or multiplexed RT-qPCR applications as well as high throughput gene-expression studies. The system has been optimised to deliver maximum RT-qPCR efficiency, sensitivity, and specificity in reduced reaction volumes and fast cycle times. Ultra-Plex™ 1-Step ToughMix® contains all required components for RT-qPCR except RNA template and probe. It is compatible with all dual-labeled probe chemistries.
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Human Recombinant IL-9
Supplier: STEMCELL Technologies
Interleukin 9 (IL-9) has pleiotropic functions in the immune system and signals through its specific IL-9 receptor (IL-9R) (Renauld et al.). IL-9/IL-9R signaling pathway mainly targets the downstream activation of JAK/STAT (janus kinase/signal transducer and activator of transcription) and subsequent phosphorylation cascades initiated by multiple kinases including IRS–PI3K–PKB (insulin receptor substrate, phosphatidyl-inositol 3-kinases, protein kinase-B) and ERK (Knoops and Renauld; Fontaine et al.). IL-9 has been shown to have a role in Th1/Th17-mediated inflammation and in regulatory T cell responses (Singh et al.; Goswami and Kaplan). IL-9/IL-9R signaling pathway represents a novel endogenous anti-apoptotic mechanism for cortical neurons (Fontaine et al.). IL-9 secreting T cells, termed Th9 cells, contribute to both effective immunity and immunopathological disease, and have been shown to have a role in the treatment of allergic and autoimmune disease (Kaplan et al.).
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Human recombinant BAFF (active) (soluble) (from E. coli)
Supplier: ProSci Inc.
BAFF is mainly produced by innate immune cells such as neutrophils, monocytes, macrophages, dendritic cells, follicular dendritic cells. T cells, activated B cells, some malignant B cells and also non-lymphoid cells like astrocytes, synoviocytes and epithelial cells can also produce BAFF. BAFF binds three distinct receptors (BAFF-R, TACI and BCMA) expressed predominantly on B cells, although activated T cells also express BAFF-R. BAFF is a master regulator of peripheral B cell survival, and together with IL-6, promotes Ig class-switching and plasma cell differentiation. Besides its major role in B cell biology, BAFF co-stimulates activated T cells. Deregulated expression of BAFF leads to autoimmune disorders in mice. In humans, elevated levels of soluble BAFF have been detected in the serum of patients with various autoimmune diseases such as Sjoegren syndrome, Rheumatoid arthritis (RA), Multiple sclerosis (MS) and Systemic Lupus Erythematosus (SLE). BAFF has also increased levels in some lymphoid cancers. Processed human BAFF can either remain as a trimer, which is usual for TNF family ligands or assemble into 60-mer composed of 20 trimers. Mouse BAFF 60-mer has been identified in the serum of BAFF transgenic mice. Oligomerisation of BAFF 3-mer into 60-mer in human BAFF is prevented by mutation of His218, a residue critical for 3-mer-to-3-mer interactions, but not for receptor binding. Despite the predominant functional role of processed BAFF in vivo, membrane-bound BAFF might also play a role. Indeed, soluble BAFF (3-mer) can trigger BAFF-R but not TACI or BCMA, whereas oligomeric forms of BAFF (BAFF 60-mer), which mimic membrane-bound BAFF, activate all BAFF receptors.
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Human Recombinant RANKL
Supplier: STEMCELL Technologies
Receptor activator of nuclear factor kappa-B ligand (RANKL) is a member of the tumor necrosis factor (TNF) superfamily (Anderson et al.). Cytokines in the TNF superfamily are involved in a variety of long-term cellular activities such as differentiation, proliferation, and cell death (MacEwan). RANKL is a type II homotrimeric transmembrane protein expressed in both a membrane-bound and secreted form (Ikeda et al.). RANKL binds to the receptor activator of nuclear factor kappa-B (RANK). Upon binding to its receptor, RANKL activates the AKT signaling pathway (Moon et al.). Osteoprotegerin (OPG) may also bind RANKL, and this binding competes with RANKL-RANK binding (Lacey et al.). RANKL is involved in osteoclastogenesis (Lacey et al.; Yasuda et al.) and T cell activation (Wong et al.).
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Human Recombinant Betacellulin
Supplier: STEMCELL Technologies
Betacellulin is a member of the epidermal growth factor (EGF) family, and signals through EGF receptor and ERBB4. It activates ERK and AKT pathways, which induces neural stem cell proliferation and prevents spontaneous differentiation in culture. Betacellulin stimulates the expansion of neural stem cells, transit-amplifying cells, and neuroblasts derived from subventricular zone and dentate gyrus (Gómez-Gaviro et al.). It is a potent mitogen for retinal pigment epithelial cells and vascular smooth muscle cells. Betacellulin down-regulates E-cadherin expression in ovarian cancer cell lines via MEK/ERK1/2 and PI3K/AKT signaling pathways, thus increasing cell migration (Zhao et al.). It is a modulator of interferon (IFN) response and enhances anti-viral effects of IFN (Al-Yahya et al.). Betacellulin is expressed in pancreatic α cells, β cells, and duct cells. It induces the proliferation of pancreatic cancer cell lines, inhibits apoptosis, promotes the neogenesis of β cells, and converts non-β cells into insulin-producing cells (Kawaguchi et al.; Miyagawa al.; Saito et al.).
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VIAL WITHOUT SNAPCAP 10ML 1 * 100 items
Supplier: Roth Carl
VIAL WITHOUT SNAPCAP 10ML 1 * 100 items
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Syringe 10Ul Rn 23Ga. 1 * 1 items
Supplier: Agilent
Syringe 10Ul Rn 23Ga. 1 * 1 items
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MULTI-GUARD-FILTER-TIPS 0,5-10µl 1 * 960 items
Supplier: Roth Carl
MULTI-GUARD-FILTER-TIPS 0,5-10µl 1 * 960 items
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Recombinant protein, mas1 (np_002368.1) recombinant protein without tag. 1 * 2 µG
Supplier: Abnova
Recombinant protein, mas1 (np_002368.1) recombinant protein without tag. 1 * 2 µG
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1-Oleoyl-2-Acetyl-Sn-Glycerol (1Set = 10X500Ug) 1 * 1 SET
Supplier: Merck Millipore (Calbiochem)
1-Oleoyl-2-Acetyl-Sn-Glycerol (1Set = 10X500Ug) 1 * 1 SET
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TIP EJECTOR-PART 1 1 * 1 items
Supplier: Thermo Fisher Scientific
TIP EJECTOR-PART 1 1 * 1 items
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EZ PACKING SLEEVE 10MM 1 * 1 items
Supplier: OMNIFIT
EZ PACKING SLEEVE 10MM 1 * 1 items
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SPITZE FILTER SSNC 0,5-10µL C ST (8X96) 1 * 768 ST
Supplier: BIOZYM
SPITZE FILTER SSNC 0,5-10µL C ST (8X96) 1 * 768 ST
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HYDROMETER BAUME 1-3 0,1 15C 1 * 1 items
Supplier: GERING
HYDROMETER BAUME 1-3 0,1 15C 1 * 1 items
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Recombinant protein, ccr10 (aah98132.1) recombinant protein without tag. 1 * 2 µG
Supplier: Abnova
Recombinant protein, ccr10 (aah98132.1) recombinant protein without tag. 1 * 2 µG
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Precision therm., straight stem, -5+100:0,2C, capillary tube specially coated inside, with non-wetting blue special liquid, upper part 350x11mm, lower part 100x7-8mm, null
Supplier: Amarell
Precision therm., straight stem, -5+100:0,2C, capillary tube specially coated inside, with non-wetting blue special liquid, upper part 350x11mm, lower part 100x7-8mm, null
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BARREL ASSEMBLY 10µL 1 * 1 items
Supplier: Socorex Isba
BARREL ASSEMBLY 10µL 1 * 1 items
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ISOVERSINIC TUBING 12/17 ISO 1 * 1 m
Supplier: GERHARDT
ISOVERSINIC TUBING 12/17 ISO 1 * 1 m
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dNTPs for cDNA Probe Synthesis 1 * 300 µl
Supplier: Ambion
dNTPs for cDNA Probe Synthesis 1 * 300 µl
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PVC-TUBE 10X1MM L=400MM 1 * 1 items
Supplier: GERHARDT
PVC-TUBE 10X1MM L=400MM 1 * 1 items
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Flask volumetric, capacity 20ml, glass stopper, class A, NS 12/21, amber graduation, conformity certified. 1 * 2 items
Supplier: HIRSCHMANN
Flask volumetric, capacity 20ml, glass stopper, class A, NS 12/21, amber graduation, conformity certified. 1 * 2 items
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AutoCollect™ Specimen Collection Cards
Supplier: Ahlstrom-Munksjö
Ahlstrom AutoCollect™ specimen collection cards for high-throughput environments work efficiently in both DBS punch and direct elution. They are designed for microvolume sampling, transport and storage of dried blood spot (DBS) at ambient temperature.
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NucleoBond Xtra Buffer Set I buffer set for the isolation of low-copy plasmids, BACs, PACs, and P1 constructs, only applicable with NucleoBond Xtra kits, sufficient for 12 Xtra Maxi preps or 18 Xtra Midi preps - Buffer RES, Buffer LYS, Buffer NEU, RN 1 * 1 SET
Supplier: MACHEREY-NAGEL
NucleoBond Xtra Buffer Set I buffer set for the isolation of low-copy plasmids, BACs, PACs, and P1 constructs, only applicable with NucleoBond Xtra kits, sufficient for 12 Xtra Maxi preps or 18 Xtra Midi preps - Buffer RES, Buffer LYS, Buffer NEU, RN 1 * 1 SET
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Human Recombinant bFGF
Supplier: STEMCELL Technologies
Basic fibroblast growth factor (bFGF) is a prototypic member of the fibroblast growth factor family. Cytokines in the FGF family possess broad mitogenic and cell survival activities (Folkman and Klagsbrun; Kimelman and Kirschner) and are involved in a variety of biological processes including cell proliferation, differentiation, survival, and apoptosis (Folkman and Klagsbrun; Klagsbrun; Rifkin and Moscatelli). bFGF has the β-trefoil structure (Ponting and Russell), binds to the four FGF receptor (FGFR) family members, and activates JAK/STAT, PI3K, ERK1/2, and other receptor tyrosine kinase (RTK) signaling pathways. It supports the maintenance of undifferentiated human embryonic stem cells (Xu et al.; Kang et al.), stimulates human embryonic stem cells to form neural rosettes (Zhang et al.), and improves proliferation of human mesenchymal stem cells and enhances chondrogenic differentiation (Solchaga et al.).
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Human Recombinant IL-1 beta, ACF
Supplier: STEMCELL Technologies
Interleukin 1 beta (IL-1β) is synthesised as an inactive precursor protein or pro-IL-1β. This precursor is cleaved intracellularly by Caspase 1 (IL-1β convertase) to form the active form of the protein that is later secreted (Allan et al.). IL-1β binds to IL-1 receptor and activates intracellular signaling via the MAPK or NF-kB pathway. IL-1β is released by monocytes, tissue macrophages, and dendritic cells in response to infection or injury and induces expression of acute-phase proteins. It also promotes the infiltration of inflammatory and immunocompetent cells from the circulation into the extravascular space and affected tissues, by stimulating the expression of adhesion molecules on endothelial cells. IL-1β also affects other immune cells; for example, it co-stimulates T cell functions together with antigen or mitogen. It also stimulates Th17 differentiation and B cell proliferation in an IL-6-dependent manner. This product is animal component-free.
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FLASK ANTIBIOTIC MOISTURE CONTENT 1 * 1 items
Supplier: DWK Life Sciences
FLASK ANTIBIOTIC MOISTURE CONTENT 1 * 1 items
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BINOCULAR PHOTOTUBE 20/23 100:0/0:100 1 * 1 items
Supplier: ZEISS
BINOCULAR PHOTOTUBE 20/23 100:0/0:100 1 * 1 items
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Recombinant protein, epcam (np_002345.1) recombinant protein without tag. 1 * 2 µG
Supplier: Abnova
Recombinant protein, epcam (np_002345.1) recombinant protein without tag. 1 * 2 µG