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111962 results for "Chlorpheniramine+maleate&pageNo=10&view=list"

111962 Results for: "Chlorpheniramine+maleate&pageNo=10&view=list"

Human Recombinant CNTF

Human Recombinant CNTF

Supplier: STEMCELL Technologies

Ciliary neurotrophic factor (CNTF) is a neurotrophic factor that belongs to the four-helix bundle cytokine family and is structurally related to interleukin 6 (IL-6), interleukin 11 (IL-11), leukemia inhibitory factor (LIF), and oncostatin M (OSM). CNTF binds to its receptor CNFTRα and induces formation of a heterodimer of the signal-transducing IL-6 receptor gp130 and LIF receptor (LIFR)-β, which triggers JAK/STAT, ERK, and the PI3K signaling cascades (Schuster et al.). CNTF plays an important role in neurogenesis and the differentiation of neural stem cells and has been suggested to possess a therapeutic role in treating neurological disorders (Ding et al.; Oppenheim et al.). CNTF has also been shown to protect rod photoreceptors from light-induced damage and to have therapeutic effects on retinal degenerative diseases caused by genetic defect or damage induced by toxins, autoantibodies, or strong light (Pernet et al.; Rhee et al.). Another therapeutic role of CNTF has been reported in protecting oligodendrocytes from death induced by apoptosis (Louis et al.). Additionally, CNTF is commonly used to differentiate human pluripotent stem cell (hPSC)-derived neural progenitor cells into astrocytes (Krencik and Zhang).

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Flask, volumetric, capacity 25ml, class A, USP certificate 1 * 1 items

Flask, volumetric, capacity 25ml, class A, USP certificate 1 * 1 items

Supplier: HIRSCHMANN

Flask, volumetric, capacity 25ml, class A, USP certificate 1 * 1 items

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Cubis® II MCA 226S Ultra-High Resolution Semi-Micro Balances

Cubis® II MCA 226S Ultra-High Resolution Semi-Micro Balances

Supplier: Sartorius Balances

The Cubis® II laboratory balances are modular, therefore they allow to choose between applications and configurations which suit the best to the needs. These balances can be configured at the level of display, draftshields, software applications and hardware functions.

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Recombinant protein, ccdc109a( np_612366.1, 1 a.a. - 351 a.a.) full-length recombinant protein with gst tag. 1 * 2 µG

Supplier: Abnova

Recombinant protein, ccdc109a( np_612366.1, 1 a.a. - 351 a.a.) full-length recombinant protein with gst tag. 1 * 2 µG

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VISCOTESTER IQ PACK FOR PASTES TM-PE-P 1 * 1 SET

Supplier: HAAKE

VISCOTESTER IQ PACK FOR PASTES TM-PE-P 1 * 1 SET

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VOL.FLASK 20ML NS10/19 AMBER POLYSTOPP A 1 * 1 items

VOL.FLASK 20ML NS10/19 AMBER POLYSTOPP A 1 * 1 items

Supplier: HIRSCHMANN

VOL.FLASK 20ML NS10/19 AMBER POLYSTOPP A 1 * 1 items

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Tip pipette 10µl hinged rack certified sterile 1 * 960 items

Supplier: USA SCIENTIFIC PLASTICS

Tip pipette 10µl hinged rack certified sterile 1 * 960 items

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BLADE WASHED DEFATTED 1-1.2SCIENTV 1 * 1.000 items

Supplier: KNITTEL

BLADE WASHED DEFATTED 1-1.2SCIENTV 1 * 1.000 items

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TIP EJECTOR UPPER PART 10ML FP-FOCUS 1 * 1 items

Supplier: Thermo Fisher Scientific

TIP EJECTOR UPPER PART 10ML FP-FOCUS 1 * 1 items

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TUBE MEASURING FOR WATER ESTIMATORS, ACCESSORYTO DEANSTARK, 25ML-0.1ML, ST-STOPCOCK, WITH SHORT SIDE ARM ST29/32 NOT DIN 1 * 1 items

Supplier: witeg Labortechnik

TUBE MEASURING FOR WATER ESTIMATORS, ACCESSORYTO DEANSTARK, 25ML-0.1ML, ST-STOPCOCK, WITH SHORT SIDE ARM ST29/32 NOT DIN 1 * 1 items

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GLOVE REDCOTE PLUS PVC 35CM T 10XL 1 * 12 PAIR

Supplier: Honeywell Safety

GLOVE REDCOTE PLUS PVC 35CM T 10XL 1 * 12 PAIR

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Human Recombinant PDGF-BB

Human Recombinant PDGF-BB

Supplier: STEMCELL Technologies

Platelet-derived growth factor (PDGF) is a dimeric glycoprotein consisting of two disulfide bridge stabilized polypeptide chains, A and B, which are assembled as heterodimers (PDGF-AB) or homodimers (PDGF-AA and PDGF-BB) (Fretto et al.; Westermark and Heldin). PDGF signals through the receptor tyrosine kinases PDGFRalpha and PDGFRbeta. It has been shown that PDGF-induced migration involves signaling pathways involving MEK/ERK, EGFR, Src and PI3K/AKT (Kim et al.). PDGF is a potent mitogen for cells of mesenchymal origin- like fibroblasts, glial cells, and vascular smooth muscle cells. PDGF has been implicated in pathogenesis of atherosclerosis, glomerulonephritis, cancer, and in the contraction of vascular smooth muscle cells of rat aortic tissues (Fretto et al.; Sachinidis et al.). PDGF-BB is secreted by osteoblasts to induce mesenchymal stem cell migration and angiogenesis. It has also been shown that PDGF-BB is secreted by preosteoclasts during bone modeling and remodeling to induce angiogenesis and thus proper osteogenesis (Xie et al.).

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Genomic DNA purification kits, Fast DNA™ SPIN kit for Soil, MP Biomedicals

Supplier: MP Biomedicals

The FastDNA™ SPIN Kit for Soil is designed to efficiently isolate bacterial, fungi, plant and animal genomic DNA from soil and environmental samples.

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Glass screw top vials, 2 ml, level 2 high-throughput applications, SureSTART™

Glass screw top vials, 2 ml, level 2 high-throughput applications, SureSTART™

Supplier: Thermo Fisher Scientific

Choose Thermo Scientific™ SureSTART™ 2 ml glass screw top vials, performance level 2, to ensure high quality data with an uninterrupted workflow in high-throughput applications using GC, HPLC/UHPLC, and single or triple quadrupole MS systems. Use level 2 vials for routine QA/QC applications, where the analyte levels are achievable or close to the method detection level. Available in clear and amber glass, these 2 ml screw top vials have very low metal content, extractables, and leachables and conform to high standards so that you can to meet your regulatory requirements. They are specification certified to ensure their physical dimensions and autosampler compatibility.

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L(+)-Cysteine hydrochloride monohydrate, Millipore®

Supplier: Merck

L(+)-Cysteine hydrochloride monohydrate, Millipore®

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ESTRIOL IMP. F (EP):16-EPI-ESTRIOL 1 * 100 mg

Supplier: LGC Standards PROMOCHEM

ESTRIOL IMP. F (EP):16-EPI-ESTRIOL 1 * 100 mg

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Human Recombinant Heregulin-beta 1

Human Recombinant Heregulin-beta 1

Supplier: STEMCELL Technologies

Heregulin-beta 1 also known as neuregulin-1 (NRG-1) is a member of the epidermal growth factor (EGF) family of growth factors and acts as a ligand for ErbB family receptor tyrosine kinases (Britsch et al.). Heregulin/neuregulin is a family of structurally related polypeptide growth factors derived from alternatively spliced genes (NRG1, NRG2, NRG3, and NRG4). Heregulin-beta 1 plays an important role during the development of the nervous system, heart, and mammary glands (Britsch). Heregulin-beta 1 is expressed in neuronal cells, and modulates cell growth and differentiation of the cells during development and wound healing (Mei and Xiong). It has been implicated through in vivo and in vitro studies that heregulin-beta 1/ErbB signaling is crucial for multiple aspects of cardiovascular development and protects the heart from ischemic injury (Odiete et al.). Heregulin-beta 1 also promotes invasiveness and metastasis of breast cancer cells (Hutcheson et al.). It has also been shown that heregulin-beta 1 has a role in the growth and maintenance of human embryonic stem cells (Wang et al.).

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Volumetric flask, PMP, class B, with stopper NS 12/21, PP, 50 mL 1 * 2 items

Supplier: VITLAB

Volumetric flask, PMP, class B, with stopper NS 12/21, PP, 50 mL 1 * 2 items

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titanium probe TS 106, titanium probe, dia. 6 mm, for HD 4050/4100/4200 1 * 1 items

Supplier: BANDELIN-ELECTRONIC

titanium probe TS 106, titanium probe, dia. 6 mm, for HD 4050/4100/4200 1 * 1 items

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Genomic RNA purification kits, Fast RNA™ Pro Blue kit, MP Biomedicals

Genomic RNA purification kits, Fast RNA™ Pro Blue kit, MP Biomedicals

Supplier: MP Biomedicals

FastRNA® Pro Blue Kit is used to isolate total RNA from gram positive and gram negative bacteria. Isolated RNA is suitable for RT-PCR analysis and other downstream applications.

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Flasche, Weithals, Material: PE-LD, Inhalt: 1000 ml, Hals I-Dmr: 43 mm, DmrxH: 96x186 mm, Farbe: naturfarbig, mit grünem Schraubdeck el 1 * 100 ST

Supplier: EDER KARL ROBUST

Flasche, Weithals, Material: PE-LD, Inhalt: 1000 ml, Hals I-Dmr: 43 mm, DmrxH: 96x186 mm, Farbe: naturfarbig, mit grünem Schraubdeck el 1 * 100 ST

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SQUARE BOTTLE 500ML HDPE NA H147 Ø29, 10MG SODIUM THIO, LABEL WH & TAMPER EVIDENT HINGED PLUG RE, IONISED 1 * 100 items

Supplier: Corning

SQUARE BOTTLE 500ML HDPE NA H147 Ø29, 10MG SODIUM THIO, LABEL WH & TAMPER EVIDENT HINGED PLUG RE, IONISED 1 * 100 items

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Flask volumetric, capacity 20ml, USP individual certificate, class A, graduated, conformity certified. 1 * 1 items

Flask volumetric, capacity 20ml, USP individual certificate, class A, graduated, conformity certified. 1 * 1 items

Supplier: HIRSCHMANN

Flask volumetric, capacity 20ml, USP individual certificate, class A, graduated, conformity certified. 1 * 1 items

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Valve discharge for DURAN Group dispenser PRO 2,5/5/10ml (PFA/Borosilicate glass/Platin-Iridium) 1 * 1 items

Supplier: DWK Life Sciences

Valve discharge for DURAN Group dispenser PRO 2,5/5/10ml (PFA/Borosilicate glass/Platin-Iridium) 1 * 1 items

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WHM12019,Aℓ-case Heating Mantles with Controller, 450℃, for 10,000ml Spherical flask(DU) 1 * 1 items

Supplier: witeg Labortechnik

WHM12019,Aℓ-case Heating Mantles with Controller, 450℃, for 10,000ml Spherical flask(DU) 1 * 1 items

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Syringe 10ml 20Gx1 inch Luer-Lok 1 * 400 items

Supplier: BD Medical

Syringe 10ml 20Gx1 inch Luer-Lok 1 * 400 items

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Volumetric flask, PP, class B, with screw cap, PP, 100 mL 1 * 2 items

Supplier: VITLAB

Volumetric flask, PP, class B, with screw cap, PP, 100 mL 1 * 2 items

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flat bottom glass 36x1,4x120mm 54mm with ring mark fused straight bottom ca.45ml ring mark mark at 54+-0,5mm inside measured straight bottom straight rim fused (pour point glass ) from Boro 3.3 1 * 1 items

Supplier: NEUBERT VOLUME GLASSWAERE

flat bottom glass 36x1,4x120mm 54mm with ring mark fused straight bottom ca.45ml ring mark mark at 54+-0,5mm inside measured straight bottom straight rim fused (pour point glass ) from Boro 3.3 1 * 1 items

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Human Recombinant SCF (E. coli-expressed)

Human Recombinant SCF (E. coli-expressed)

Supplier: STEMCELL Technologies

Stem cell factor (SCF) is an early-acting cytokine that plays a pivotal role in the regulation of embryonic and adult hematopoiesis. SCF promotes cell survival, proliferation, differentiation, adhesion, and functional activation of cells at multiple levels of the hematopoietic hierarchy. Together with other cytokines such as thrombopoietin and Flt3/Flk-2 Ligand, SCF is commonly used to promote expansion of primitive hematopoietic stem cells and multi-potent progenitor cells in culture (Martin et al.; Kent et al.). In synergy with various growth factors, including IL-2, IL-3, IL-6, IL-7, G-CSF, and erythropoietin, SCF increases proliferation and differentiation of myeloid and erythroid progenitor cells and a subset of lymphoid progenitor cells (Broudy). SCF is also a primary growth and activation factor for mast cells and eosinophils. SCF exists in two biologically active splice forms: a soluble and a transmembrane isoform. Upon binding to its receptor (c-Kit tyrosine kinase receptor; CD117), it activates PI3K, JAK/STAT, and MAPK pathways. SCF and signaling from c-Kit have also been reported to play an important role in pigmentation, fertility, vasculogenesis, motility of the gut via c-Kit positive interstitial cells of Cajal, and in the migration of neuronal stem and progenitor cells to sites of injury in the brain.

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Human Recombinant M-CSF, ACF

Human Recombinant M-CSF, ACF

Supplier: STEMCELL Technologies

Macrophage colony-stimulating factor (M-CSF) is a homodimeric glycoprotein growth factor that regulates proliferation and differentiation of myeloid hematopoietic progenitors to mononuclear phagocytic cell lineages, including monocytes, macrophages, and osteoclasts. M-CSF is a crucial factor for the development of tissue-resident macrophages in most tissues (Ginhoux andamp; Jung). It is required for the maturation and activation of monocytes and macrophages, and regulates inflammatory responses in conjunction with other stimuli such as IFN-γ, LPS, and IL-4 (Murray et al.). M-CSF is also required for bone resorption by osteoclasts, and is involved in the development and regulation of placenta, mammary gland, and brain. M-CSF is produced by monocytes, fibroblasts, osteoclasts, stromal cells, endothelial cells, and tumor cells (Chockalingam andamp; Ghosh). M-CSF exerts its biological effects by signaling through a receptor tyrosine kinase (CSF-1R or M-CSF-R) encoded by the c-fms proto-oncogene (Hamilton). CSF-1R shares similar structural features with other growth factor receptors, including the stem cell factor (SCF) receptor, platelet-derived growth factor receptor (PDGF-R), and Flt3/Flk-2 receptor tyrosine kinase. Stimulation of the CSF-1R upon binding to M-CSF activates MAPK, PI3K, and PLCγ signaling pathways (Chockalingam andamp; Ghosh). Human and mouse M-CSF sequences are highly conserved both at nucleotide and amino acid levels (80% homology; DeLamarter et al.). This product is animal component-free.

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