Supplier: ProSci Inc.

Epithelial Cell Adhesion Molecule (EpCAM) is a signal type I transmembrane glycoprotein that belongs to the EPCAM family. EpCAM is composed of an extracellular domain with one thyroglobulin type-1 domain, a transmembrane domain and a cytoplasmic domain. EpCAM is found on the surface of adenocarcinoma, but not on mesodermal or neural cell membranes. The EpCAM molecule has been shown to function as a homophilic Ca2+ independent adhesion molecule. It may act as a physical homophilic interaction molecule between intestinal epithelial cells (IECs) and intraepithelial lymphocytes (IELs) at the mucosal epithelium as an immunological barrier providing the first line of defense against infection. Defects in EPCAM are a cause of hereditary non-polyposis colorectal cancer type 8 (HNPCC8) and diarrhea type 5 (DIAR5). EpCAM plays a role in embryonic stem cells proliferation and differentiation; it up-regulates the expression of FABP5, MYC and Cyclin A and Cyclin E. It is highly and selectively expressed by undifferentiated embryonic stem cells.

Supplier: ENZO LIFE SCIENCES

CaMKIIa, the alpha subunit of Ca2+ calmodulin-dependent protein kinase II is part of a family of multifunctional protein kinases, which play a major role in Ca2+-mediated signal transduction.  CaMKIIa is expressed in many different tissues but is specifically found in the neurons of the forebrain and its mRNA is found within the dendrites as well as the soma of the neuron.  The neuronal CaMKII consists of two major subunits of 52 and 60 kDa which are encoded by a- and b-CaMKII genes, respectively.  Additional isoforms are generated by alternative splicing of these as well as of the ubiquitious g- and d-CaMKII genes.  Each subunit has an ATP-binding domain (arginine-X-X-serune/threonine), consensus phosphorylation site, catalytic domain, and a centrally located regulatory domain which has calmodulin binding activity. Activation and autophosphorylation of CaMKII may regulate numerous neuronal processes which includes two forms of synaptic plasticity, long term potentiation and long term depression.  Neuronal CaMKII subunits assemble as large multimeric holoenzymes.  The C-terminal association domains of  6-12 subunits assemble into a central globular structure from which the N-terminal catalytic/regulatory domains extend radially like petals of a flower. The subunit composition of the rat forebrain CaMKII holoenzyme consists of heteromers composed of a and β subunits at a ratio of 2:1 and homomers composed of only a subunits.  The association of CaMKII subunits leads to the positioning of their catalytic/regulatory domains in close proximity and the neighboring calmodulin-bound subunits cooperate to rapidly phosphorylate each other.  Autophosphorylation also enables CaMKII to attain an enhanced affinity for NMDA receptors in postsynaptic densities.

Supplier: MP Biomedicals

White Granules 1 * 1 kg

Supplier: Biorbyt

S100A11 Human Recombinant is expressed in E.coli having molecular weight of 17kDa fused to an amino terminal hexahistidine tag. 1 * 2 µG

Supplier: Biorbyt

S100A11 Human Recombinant is expressed in E.coli having molecular weight of 17kDa fused to an amino terminal hexahistidine tag. 1 * 10 µG

Supplier: Biorbyt

S100A10 Human Recombinant also called Calpactin light chain is expressed in E.coli having molecular weight of 15.3kDa fused to an am ino terminal hexahistidine tag. 1 * 2 µG

Supplier: Biorbyt

S100A10 Human Recombinant also called Calpactin light chain is expressed in E.coli having molecular weight of 15.3kDa fused to an am ino terminal hexahistidine tag. 1 * 10 µG

Supplier: Biorbyt

S100A6 also called Calcyclin has been purified by HPLC (see Kuznicki et al. (1989) Biochem. J. 263 951-956). 1 * 5 µG

Supplier: Biorbyt

S100A6 also called Calcyclin has been purified by HPLC (see Kuznicki et al. (1989) Biochem. J. 263 951-956). 1 * 10 µG

Supplier: Biorbyt

S100B Human Recombinant produced in E.coli is a single, non-glycosylated, Polypeptide containing 91 amino acids fragment (2-92) wit h an amino-terminal hexahistidine tag and having total molecular mass of 14.7kDa. The S100B is purified by p 1 * 5 µG

Supplier: Biorbyt

S100B Human Recombinant produced in E.coli is a single, non-glycosylated, polypeptide chain fused to GST tag and having total molecu lar mass of 36kDa. The S100B is purified by proprietary chromatographic techniques. 1 * 5 µG

Supplier: Biorbyt

S100B Human Recombinant produced in E.coli is a single, non-glycosylated, polypeptide chain fused to GST tag and having total molecu lar mass of 36kDa. The S100B is purified by proprietary chromatographic techniques. 1 * 10 µG

Supplier: Biorbyt

S100B Human Recombinant produced in E.coli is a single, non-glycosylated, Polypeptide containing 91 amino acids fragment (2-92) wit h an amino-terminal hexahistidine tag and having total molecular mass of 14.7kDa. The S100B is purified by p 1 * 20 µG

Supplier: PerkinElmer

SYMBOL: CA, MATRIX: HYDROCARBON OIL, SIZE: 50 G. METALLO-ORGANIC METALS IN HYDROCARBON OIL. ACCURACY ENSURED BY QUALITY TESTING WITH NIST STANDARD REFERENCE MATERIALS WHEN AVAILABLE. CERTIFICATE OF ANALYSIS SUPPLIED WITH EACH STANDARD. 1 * 1 items

Supplier: SHERWOOD SCIENTIFIC INSTRUMENT

Calibration standard1000ppmCalcium 6 x 100ml pk 1 * 600 mL

Supplier: Biorbyt

S100B Human Recombinant produced in E.coli is a single, non-glycosylated, polypeptide chain fused to GST tag and having total molecu lar mass of 36kDa. The S100B is purified by proprietary chromatographic techniques. 1 * 2 µG

Supplier: Biorbyt

S100A6 also called Calcyclin has been purified by HPLC (see Kuznicki et al. (1989) Biochem. J. 263 951-956). 1 * 2 µG

Supplier: Biorbyt

The Recombinant Human S100P has molecular mass of 10.4 kDa containing 95 amino acid residues of the human S100P.MTELEAAMGM IIDVFSRYS G SEGSTQTLTK GELKVLMEKE LPGFLQSGKD KDAVDKLLKD LDANGDAQVD FSEFIVFVAA ITSACHKYFE KAGLK. 1 * 2 µG

Supplier: Biorbyt

The Recombinant Human S100P has molecular mass of 10.4 kDa containing 95 amino acid residues of the human S100P.MTELEAAMGM IIDVFSRYS G SEGSTQTLTK GELKVLMEKE LPGFLQSGKD KDAVDKLLKD LDANGDAQVD FSEFIVFVAA ITSACHKYFE KAGLK. 1 * 10 µG

Supplier: MARKET SOURCE PART PROCESS

Flasche Calciumhydrid 250 g, Körnung 0,5 - 2 mm 1 * 250 g

Supplier: AZELIS

Calciumthioglycolat-Trihydrat 1 * 1 kg

Supplier: AZELIS

Calciumthioglycolat-Trihydrat 1 * 75 kg

Supplier: Diversey

Solo is a hard water tolerant, low foaming, low freezing point liquid caustic detergent for dairy heat treated surface CIP applications. Solo is used for single stage CIP recovery cleaning in a wide range of applications, including cold surfaces as well. Solo can be used to clean a wide range of applications in dairy, e.g. HTST, homogenisers, storage, mixing and ageing tanks used in ice cream manufacture. Solo can be used to clean a wide range of applications across the food and beverage industries, e.g. vegetable evaporators in processed foods plants.

Supplier: ENZO LIFE SCIENCES

CaMKII (calmodulin-dependent kinase II) is an enzyme which is activated by increases in intracellular Ca2+ ion concentration and it has been proposed to be pivotal in regulating synaptic strength and maturation of synapses during development.  This process is thought to be critical in memory and learning and in establishing the specificity of synaptic connections. There are over two dozen alternative splice variants of CaMKII which are encoded by four genes, a, b, g, and d with apparent molecular masses of 50-60 kDa.  CaMKII is widely distributed in many tissues, but is highly expressed in brain. Several studies demonstrate that CaMKII is a multifunctional enzyme which modulates the synaptic strength by binding to a subunit of NMDA receptors and promoting the phosphorylation of this NMDA receptor subunit.  CaMKII also regulates DLG localization at synapses by co-localization with DLG in the same protein complex.  Experimental data suggest that CaMKII is critically involved in the development of morphine tolerance as well as dependence and inhibition of this enzyme may have some therapeutic benefit in the treatment of opiate tolerance and dependence.  It also has been demonstrated that d CaMKII isozyme is down-regulated in human tumor cells indicating a role for d CaMKII isozymes in cellular differentiation.  Changes in d CaMKII isozyme expression pattern in human hearts during heart failure suggest that CaMKII is important for regulation of heart function.  This immunoaffinity purified antibody detects proteins of 50-60 kDa, corresponding to apparent molecular mass of CaMKII isoforms on SDS-PAGE immunoblots, in samples from human, mouse, rat, bovine, hamster, guinea pig, chicken and rabbit origins. Recombinant rat calmodulin-dependent protein kinase II a subunits expressed in sf9 insect cells are also detected. As the sequences of the rat a, d, and g isoforms are conserved over this amino terminus region, this antibody is expected to recognize the d, g and a isoforms. This antibody is not expected to cross-react with the b isoform. Proteins of unknown identity, ~40, 45 and 90 kDa, may be detected on immunoblot analysis with some lysates.

Supplier: MACHEREY-NAGEL

Spare syringe C 20/SBV VISOCOLOR. 1 * 1 items

Supplier: CUSTOM MADE CHEMICALS LAB

11 COMPONENTS MIX 1 * 500 mL