37509 Results for: "Bis[4,4\\\'-dimethoxy(dithiobenzil)]nickel(II)"

Supplier: STEMCELL Technologies

Use Interferon beta (IFN-β) to modulate the activity of genes that control dendritic cell activation, T cell survival, NK cell activation, chemokine expression, lymph node retention, and antiproliferative and antiviral effects (Dunn et al. Nat Rev Immunol, 2006). IFN-β binds to a receptor complex composed of IFNAR1 and IFNAR2, and initiates signal transduction via the JAK/STAT pathway. It is predominantly produced by fibroblasts, with smaller amounts from plasmocytoid dendritic cells. Macrophages and endothelial cells secrete IFN-β in response to viral infection (Reder and Feng. Front Immunol, 2013). IFN-β suppresses Th17 cells by affecting expression of IL-4, IL-10, and IL-27, and is a first-line treatment for multiple sclerosis. IFN-β was also shown to expand regulatory T cells and limit T cell trafficking to the central nervous system (Inoue and Shinohara. Immunology, 2013). Of the two IFN-β variants (IFN-β1 and IFN-β3), this product is the IFN-β1 form.

Supplier: STEMCELL Technologies

Interleukin 6 (IL-6) is a pleiotropic growth factor with the wide range of biological activities in immune regulation, hematopoiesis, and oncogenesis. IL-6 is produced by a variety of cell types including T cells, B cells, monocytes and macrophages, fibroblasts, hepatocytes, vascular endothelial cells, and various tumor cell lines. On its own or in combination with other factors such as IL-2 and interferon-γ, IL-6 stimulates the proliferation of B cells, T cells, and hybridoma cells (Hirano et al.; Mihara et al.; Tanaka et al). In combination with cytokines such as IL-3, GM-CSF and SCF, IL-6 has been shown to promote hematopoietic progenitor cell proliferation and differentiation in vitro. IL-6 signals through a cell surface type I cytokine receptor complex consisting of the ligand-binding IL-6α (CD126) and the signal-transducing gp130 subunits. The binding of IL-6 to its receptor system includes activation of JAK/STAT signaling pathway (Mihara et al.; Peters et al.; Tanaka et al.).

Supplier: STEMCELL Technologies

Macrophage inflammatory protein-4 (MIP-4) plays a role in adaptive and innate immune responses, acting as a chemoattractant for T and B lymphocytes, and natural killer cells (Krohn et al.). MIP-4 can also induce immune tolerance through its effects on dendritic cells and macrophages (Azzaoui et al., Schraufstatter et al.). In breast cancer, MIP-4 has been shown to promote the invasiveness and metastasis of cancer cells in vivo by binding PITPNM3 (Chen et al.).This small cytokine belongs to the chemokine family found only in primates. Based on amino acid sequence, MIP-4 is closely related to MIP-1 alpha (CCL3) and MIP-1 beta (CCL4) (Liang et al.). MIP-4 is produced by antigen-presenting immune cells including dendritic cells, macrophages, and monocytes (Lieshout et al.). For consistency and reproducibility across your applications, macrophage inflammatory protein-4 from STEMCELL comes lyophilised with ≥95% purity, and is verified by LAL analysis to ensure endotoxin levels are ≤1,0 EU/μg protein.

Supplier: STEMCELL Technologies

Use omentin for the maintenance of insulin sensitivity and metabolism, decreasing levels of this adipokine have been associated with obesity, insulin resistance, and diabetes (Tan et al.). Studies have suggested that omentin may have protective effects against atherosclerosis, arterial calcification, and myocardial injury through AMP-activated protein kinase (AMPK) and Akt-dependent mechanisms (Xu et al., Kataoka et al.). Through regulation of Sirt1-dependent p53 deacetylation, omentin can inhibit proliferation and induce apoptosis in hepatocellular carcinoma cells (Zhang and Zhou). Omentin is mainly produced by visceral adipose tissue, but is also expressed in the small intestine, colon, mesothelial cells, vascular cells, and plasma (Watanabe et al). Protein sequence analysis has shown that omentin comprises 313 amino acids, with a secretory signal sequence and fibrinogen-related domain (Yang et al.). For consistency and reproducibility across your applications, Omentin from STEMCELL comes lyophilised with ≥90% purity, and is verified by LAL analysis to ensure endotoxin levels are ≤5,0 EU/μg protein.

Supplier: STEMCELL Technologies

Interleukin 6 (IL-6) is a pleiotropic growth factor with a wide range of biological activities in immune regulation, hematopoiesis, and oncogenesis. IL-6 is produced by a variety of cell types including T cells, B cells, monocytes and macrophages, fibroblasts, hepatocytes, vascular endothelial cells, and various tumor cell lines. On its own or in combination with other factors such as IL-2 and interferon-γ, IL-6 stimulates the proliferation of B cells, T cells, and hybridoma cells (Nordan et al.; Van Snick et al.; Gauldie et al.; Mihara et al.; Tanaka et al). In combination with cytokines such as IL-3, GM-CSF, and SCF, IL-6 has been shown to promote hematopoietic progenitor cell proliferation and differentiation in vitro. IL-6 signals through a cell surface type I cytokine receptor complex consisting of the ligand-binding IL-6α (CD126) and the signal-transducing gp130 subunits. The binding of IL-6 to its receptor system includes activation of the JAK/STAT signaling pathway (Mihara et al.; Peters et al; Tanaka et al.).

Supplier: MEMMERT

Stainless steel slide-in drip tray, 15 mm rim (may affect the temperature distribution) - cannot be used in connection with option K 1 1 * 1 items

Supplier: DELTA T

ThermoScan DATALOGGER WITH CERTIFICATE comes with a temperature range from -40°C to +80°C and a resolution of 0.5°C. The Logger allows the documenting and checking of temperatures. The logger has a rewritable memory, a real-time clock and a fully fun 1 * 1 items

Supplier: asecos

earthing link, interior earthing link for up to 6 storage levels with width 600/900/1200 mm for model(s): q90, s90, q30 1 * 1 items

Supplier: BANDELIN-ELECTRONIC

K 50 CS, INSERT BASKET, UP TO 40 KG, S/S, ID 540X445X50 MM, MESH SIZE 12,5X12,5 MM, FOR RK 1050 CH, DT 1050 CH 1 * 1 items

Supplier: MEMMERT

Reinforced stainless steel grid, max. loading 60 kg, only in connection with option k1, for icp 1 * 1 items

Supplier: BANDELIN-ELECTRONIC

FT 40 Foil test frame, suitable for interior tank dimensions from 500x300x80 mm to 500x300x300 mm, s/s 1 * 1 items

Supplier: MEMMERT

Integration of additional units (up to max. 15 units) into an already existent FDA-software licence (only for units with TwinDISPLAY ) 1 * 1 items

Supplier: MEMMERT

Stainless steel slide-in drip tray, 15 mm rim (may affect the temperature distribution) - cannot be used in connection with option K 1 1 * 1 items

Supplier: MEMMERT

Integration of additional units (up to max. 15 units) into an already existant FDA-software licence 1 * 1 items

Supplier: MACHEREY-NAGEL

NanOx Metal pack of 30g decomposition reagent with spoon and 15g neutralization reagent with micro spoon NANOCOLOR. 1 * 1 KIT

Supplier: Amarell

ELEKTRON. DIGITAL THERM. AD 15 SPEEDLAB 1 * 1 items

Supplier: asecos

2 additional power sockets fixed at th e rear wall,gap.95/125 1 * 1 items

Supplier: LAUDA

THERMOSTAT CALIBRATION LAUDA ECO REJ 1225 G TEMPERATURE RANGE -25 °C TO 200 °C COOLING POWER 0.3 kW TEMPERATURE STABILITY +/- 0.02 °C 1 * 1 items

Supplier: VITLAB

Volumetric flask, PMP, class A, with stopper NS 10/19, PP, 25 mL 1 * 2 items

Supplier: MEMMERT

Stainless steel slide-in drip tray, 15 mm rim (may affect the temperature distribution) - cannot be used in connection with option K 1 1 * 1 items

Supplier: MEMMERT

Stainless steel slide-in drip tray, 15 mm rim (may affect the temperature distribution) - cannot be used in connection with option K 1 1 * 1 items

Supplier: WTW ONLINE

Dms/n,universal flow-thru vessel for multiparameter measurements with up to four sensors, e.g. for use in the discharge of a waste w ater treatment plantplease order suitable sensor flange separately 1 * 1 items

Supplier: SI Analytics

Plug cable combination VP 6-pole electrode socket, 1 m cable KA 19 (1 coaxial + 3 cords) up to 130 °C, free end 1 * 1 items

Supplier: MEMMERT

Integration of additional units (up to max. 15 units) into an already existent FDA-software licence (only for units with TwinDISPLAY ) 1 * 1 items

Supplier: KOEHLER TECHNISCHE PRODUKTEN

Rack, flipper 1, colour yellow, material PP, autoclavable, temperature resistant -90°C to +120°C, dimension 197x95x115mm, 8 holes di ameter 30mm, 20 holes diameter 20mm. 1 * 1 items

Supplier: MEMMERT

MobileALERT for up to 4 alarm notifications notification by SMS. temperature and CO2 alarm (standard), additionally humidity alarm (when equipped with option K7) and O2 alarm (when equipped with option T6) 1 * 1 items

Supplier: STEMCELL Technologies

Betacellulin is a member of the epidermal growth factor (EGF) family, and signals through EGF receptor and ERBB4. It activates ERK and AKT pathways, which induces neural stem cell proliferation and prevents spontaneous differentiation in culture. Betacellulin stimulates the expansion of neural stem cells, transit-amplifying cells, and neuroblasts derived from subventricular zone and dentate gyrus (Gómez-Gaviro et al.). It is a potent mitogen for retinal pigment epithelial cells and vascular smooth muscle cells. Betacellulin down-regulates E-cadherin expression in ovarian cancer cell lines via MEK/ERK1/2 and PI3K/AKT signaling pathways, thus increasing cell migration (Zhao et al.). It is a modulator of interferon (IFN) response and enhances anti-viral effects of IFN (Al-Yahya et al.). Betacellulin is expressed in pancreatic α cells, β cells, and duct cells. It induces the proliferation of pancreatic cancer cell lines, inhibits apoptosis, promotes the neogenesis of β cells, and converts non-β cells into insulin-producing cells (Kawaguchi et al.; Miyagawa al.; Saito et al.).

Supplier: STEMCELL Technologies

RANTES (regulated upon activation, normal T cell expressed and secreted), also known as CCL5, is a member of the CC family of chemokines and is able to recruit leukocytes to sites of inflammation (Schall et al.). RANTES is secreted by T lymphocytes, macrophages, platelets, synovial fibroblasts, tubular epithelium, and certain types of tumor cells (Aldinucci and Colombatti; Soria and Ben-Baruch). This chemokine exerts its effect by interacting with the chemokine receptors CCR1, CCR3, CCR4, and CCR5. RANTES plays an active role in recruiting a variety of leukocytes into inflammatory sites, including T cells, macrophages, eosinophils, and basophils. In collaboration with certain cytokines that are released by T cells such as IL-2 and IFN-γ, RANTES also induces the activation and proliferation of NK cells to generate CC chemokine-activated killer cells, which are highly cytolytic (Lv et al.; Maghazachi et al.). It has been shown that RANTES produced by CD8+ T cells inhibits HIV infection of primary human peripheral blood mononuclear cells (Appay and Rowland-Jones; Cocchi et al.).

Supplier: STEMCELL Technologies

Interleukin 9 (IL-9) has pleiotropic functions in the immune system and signals through its specific IL-9 receptor (IL-9R) (Renauld et al.). IL-9/IL-9R signaling pathway mainly targets the downstream activation of JAK/STAT (janus kinase/signal transducer and activator of transcription) and subsequent phosphorylation cascades initiated by multiple kinases including IRS–PI3K–PKB (insulin receptor substrate, phosphatidyl-inositol 3-kinases, protein kinase-B) and ERK (Knoops and Renauld; Fontaine et al.). IL-9 has been shown to have a role in Th1/Th17-mediated inflammation and in regulatory T cell responses (Singh et al.; Goswami and Kaplan). IL-9/IL-9R signaling pathway represents a novel endogenous anti-apoptotic mechanism for cortical neurons (Fontaine et al.). IL-9 secreting T cells, termed Th9 cells, contribute to both effective immunity and immunopathological disease, and have been shown to have a role in the treatment of allergic and autoimmune disease (Kaplan et al.).

Supplier: STEMCELL Technologies

Commonly known as vaspin, Serpin A12 is an adipokine that is thought to perform insulin-sensitizing functions, such as the regulation of kallikrein 7 (KLK7), an insulin-inhibiting protease (Heiker et al.). The Serpin A12 glycoprotein belongs to the serine protease inhibitor family (serpin), and is mainly associated with obesity, insulin resistance, and glucose metabolism, but may also protect against high fat-induced bone loss (Wang et al.). Serpins share a highly conserved core structure with multiple α-helices, β-strands, and a reactive site loop (RCL) to interact with the target protease (Huntington). It is expressed predominantly in visceral adipose tissue and at significantly higher amounts in obese individuals (Kurowska et al.). This protein contains a His-residue tag at the carboxyl end of the polypeptide chain. For consistency and reproducibility across your applications, Serpin A12 from STEMCELL comes lyophilised with ≥94% purity, and is verified by LAL analysis to ensure endotoxin levels are ≤1,0 EU/μg protein.