Supplier: IKA

TubeRack.S.Type1.V4A.fit stainless steel rack Type 1 for baths size S 1 * 1 items

Supplier: EBRO

TPN 380, K-Type surface probe, up to 800°C, Ø 15mm, L 300mm, 1m silicone cable fixed 1 * 1 items

Supplier: MEMMERT

Integration of additional units (up to max. 15 units) into an already existant FDA-software licence 1 * 1 items

Supplier: MEMMERT

Integration of additional units (up to max. 15 units) into an already existant FDA-software licence 1 * 1 items

Supplier: MEMMERT

Integration of additional units (up to max. 15 units) into an already existant FDA-software licence 1 * 1 items

Supplier: MEMMERT

Integration of additional units (up to max. 15 units) into an already existant FDA-software licence 1 * 1 items

Supplier: MEMMERT

4 – 20 ma current loop interface temperature controller, actual value (0 to +70 °c = 4 – 20 ma) 1 * 1 items

Supplier: EBRO

K-Type surface probe TPN391, up to 800°C, Ø 15mm, L 300mm, abgewinkelt, 1m fixed silicone cable, SMP 1 * 1 items

Supplier: MACHEREY-NAGEL

School reagent case for the determination of Ammonium, Nitrate, Nitrite, Phosphate, pH and Total hardness VISOCOLOR. 1 * 1 items

Supplier: MACHEREY-NAGEL

NanOx N pack of 30g decomposition reagent with spoon and 25g compensation reagent with spoon NANOCOLOR. 1 * 30 g

Supplier: KOEHLER TECHNISCHE PRODUKTEN

GROUND CLAMP OFF POM FOR NS 29 1 * 1 items

Supplier: STEMCELL Technologies

Fractalkine (CX3CL1) is a unique chemokine belonging to the CX3C family, and is characterized by a C-X3-C cysteine motif within the chemokine domain, near the amino terminus of the protein (Bazan et al.). The chemokine domain is connected to an extended mucin-like stalk, followed by a transmembrane region, and a C-terminal intracellular domain (Imai et al.; Jones et al.). The protein signals through interaction with a single receptor, CX3CR1, expressed on monocytes, natural killer cells, T cells, microglia, and smooth muscle cells. Fractalkine is upregulated in endothelial cells by inflammatory signals and is synthesized as a membrane-bound molecule that mediates cell migration and adhesion (White and Greaves). Cleavage at the base of the stalk by metalloproteinases generates a soluble chemokine, which functions as a potent chemoattractant of target cells (Garton et al.; Apostolakis and Spandidos). Fractalkine has been implicated in pathology of inflammatory diseases, such as atherosclerosis and other vascular diseases, and has anti-apoptotic functions (White and Greaves).

Supplier: STEMCELL Technologies

Mediate calcium phosphate clearance and prevent ectopic calcification with fetuin A, a plasma glycoprotein that forms soluble complexes with calcium and phosphate (Heiss et al.; Price and Lin). Belonging to the cystatin superfamily of cysteine protease inhibitors (Brown and Dziegielewska), fetuin A has also been shown to play a role in lipid transport, acting as a carrier (Kumbla et al.). In cell-based assays, it has been suggested that fetuin A protects against lethal systemic infection through the inhibition of high mobility group box 1 (HMGB1) protein accumulation and release (Li et al.). Fetuin A acts as a natural antagonist against specific TGF-β and BMP signaling proteins, blocking osteogenic differentiation of rat bone marrow cells (Demetriou et al.). This protein contains a His-residue tag at the carboxyl end of the polypeptide chain. For consistency and reproducibility across your applications, fetuin A from STEMCELL comes lyophilised with ≥94% purity, and endotoxin levels are verified to be ≤1.0 EU/μg protein.

Supplier: STEMCELL Technologies

Stimulating T cells with SARS-CoV-2 (Spike Protein) Delta/B.1.617.2 WT reference peptide pool releases downstream cytokines and upregulates activation markers, enabling antigen-specific T cells to be detected or isolated for analysis. This peptide pool is a lyophilised mixture of 27 peptides from the spike glycoprotein of the wild-type SARS-CoV-2 virus. Consisting of the wild-type peptides that correspond to the mutated portions of the spike protein found in the SARS-CoV-2 Delta variant (B.1.617.2), this pool is recommended to be used as a reference for the SARS-CoV-2 (Spike Protein) Delta/B.1.617.2 Mutation Peptide Pool. Through interactions with the angiotensin-converting enzyme 2 (ACE2) receptor, the spike protein enables the virus to attach to the cell membrane, and plays a critical role in viral entry (Hoffmann et al.; Walls et al.). Viral peptide pools are useful for a broad range of applications, including vaccine development, immunological research, and diagnostic assay development.

Supplier: STEMCELL Technologies

Interleukin 15 (IL-15) is a four-alpha helix bundle cytokine with many similar properties to IL-2, with which it shares components of its receptor. The IL-15 receptor is a heterotrimeric receptor composed of IL-15Ra, the high-affinity receptor for IL-15, as well as IL-2/15Rb (CD122) and common gamma chain (CD132). IL-15 binds to IL-15Rα receptor and can then be presented in trans to IL-2/15Rb and common gamma chain on other cells. Trans-presentation is thought to be the major mechanism by which IL-15-mediated responses occur in mice, although may not be necessary in humans (Castillo et al.). The cytoplasmic domains of IL-2/15Rb and common gamma chain mediate signaling to activate JAK/STAT and PI3K pathways. IL-15 supports the survival and proliferation of naive CD4+ and CD8+ T cells, and promotes homeostasis of memory T cells. IL-15 also promotes the survival and differentiation of NK cells and regulates their cytolytic activity (Ma et al.).

Supplier: STEMCELL Technologies

Use Interferon beta (IFN-β) to modulate the activity of genes that control dendritic cell activation, T cell survival, NK cell activation, chemokine expression, lymph node retention, and antiproliferative and antiviral effects (Dunn et al. Nat Rev Immunol, 2006). IFN-β binds to a receptor complex composed of IFNAR1 and IFNAR2, and initiates signal transduction via the JAK/STAT pathway. It is predominantly produced by fibroblasts, with smaller amounts from plasmocytoid dendritic cells. Macrophages and endothelial cells secrete IFN-β in response to viral infection (Reder and Feng. Front Immunol, 2013). IFN-β suppresses Th17 cells by affecting expression of IL-4, IL-10, and IL-27, and is a first-line treatment for multiple sclerosis. IFN-β was also shown to expand regulatory T cells and limit T cell trafficking to the central nervous system (Inoue and Shinohara. Immunology, 2013). Of the two IFN-β variants (IFN-β1 and IFN-β3), this product is the IFN-β1 form.

Supplier: STEMCELL Technologies

Interleukin 6 (IL-6) is a pleiotropic growth factor with the wide range of biological activities in immune regulation, hematopoiesis, and oncogenesis. IL-6 is produced by a variety of cell types including T cells, B cells, monocytes and macrophages, fibroblasts, hepatocytes, vascular endothelial cells, and various tumor cell lines. On its own or in combination with other factors such as IL-2 and interferon-γ, IL-6 stimulates the proliferation of B cells, T cells, and hybridoma cells (Hirano et al.; Mihara et al.; Tanaka et al). In combination with cytokines such as IL-3, GM-CSF and SCF, IL-6 has been shown to promote hematopoietic progenitor cell proliferation and differentiation in vitro. IL-6 signals through a cell surface type I cytokine receptor complex consisting of the ligand-binding IL-6α (CD126) and the signal-transducing gp130 subunits. The binding of IL-6 to its receptor system includes activation of JAK/STAT signaling pathway (Mihara et al.; Peters et al.; Tanaka et al.).

Supplier: MEMMERT

Stainless steel slide-in drip tray, 15 mm rim (may affect the temperature distribution) - cannot be used in connection with option K 1 1 * 1 items

Supplier: MEMMERT

Integration of additional units (up to max. 15 units) into an already existant FDA-software licence 1 * 1 items

Supplier: B. Braun

Braunostat® U Universal infusion stand For stationary and mobile applications Universal Braunostat® U infusion stand for holding up to 3 infusion pumps. 1 * 1 items

Supplier: MEMMERT

Integration of additional units (up to max. 15 units) into an already existant FDA-software licence 1 * 1 items

Supplier: MEMMERT

Integration of additional units (up to max. 15 units) into an already existant FDA-software licence 1 * 1 items

Supplier: MEMMERT

Integration of additional units (up to max. 15 units) into an already existant FDA-software licence 1 * 1 items

Supplier: MEMMERT

Integration of additional units (up to max. 15 units) into an already existant FDA-software licence 1 * 1 items

Supplier: MEMMERT

Integration of additional units (up to max. 15 units) into an already existant FDA-software licence 1 * 1 items

Supplier: MEMMERT

Integration of additional units (up to max. 15 units) into an already existant FDA-software licence 1 * 1 items

Supplier: MEMMERT

Integration of additional units (up to max. 15 units) into an already existant FDA-software licence 1 * 1 items

Supplier: MEMMERT

Integration of additional units (up to max. 15 units) into an already existant FDA-software licence 1 * 1 items

Supplier: MEMMERT

Integration of additional units (up to max. 15 units) into an already existant FDA-software licence 1 * 1 items

Supplier: MEMMERT

Integration of additional units (up to max. 15 units) into an already existant FDA-software licence 1 * 1 items